Results 21 to 30 of about 599,985 (268)
Respiratory syncytial virus and neutrophil activation [PDF]
Clinical and Experimental Immunology, 2005 SummaryRespiratory syncytial virus infects almost all children by 2 years of age. Neutrophils are the predominant airway leucocytes in RSV bronchiolitis and they are activated in the presence of infection. However it is not clear whether RSV can directly signal to activate neutrophil cytotoxic function. To investigate this we have used a preparation of
E L, Bataki, G S, Evans, M L, Everard
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Porcine Trypsin in the Manufacture of Biological Medicinal Products. Risks and Safety Requirements
Биопрепараты: Профилактика, диагностика, лечение, 2018 Trypsin is a reagent widely used in the manufacture of biological medicinal products (BMPs). Until recently, pancreata of cattle, pigs and poultry were the main sources of trypsin preparations. The discovery of the disease called «transmissive spongiform
S. M. Sukhanov, E. M. Petruchuk
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Trypsin. Properties and Use in the Production of Biological Medicinal Products
Биопрепараты: Профилактика, диагностика, лечение, 2018 The production of biological medicinal products used for prophylactic, diagnostic and therapeutic purposes includes the use of inherently variable biological processes and materials.
S. M. Sukhanova +2 more
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Influenza Virus-Induced Oxidized DNA Activates Inflammasomes
iScience, 2020 Summary: Influenza virus M2 and PB1-F2 proteins have been proposed to activate the Nod-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome in macrophages by altering intracellular ionic balance or mitochondrial reactive oxygen species ...
Miyu Moriyama +5 more
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Cell Reports, 2016 Host response to RNA virus infection is sensed by RNA sensors such as RIG-I, which induces MAVS-mediated NF-κB and IRF3 activation to promote inflammatory and antiviral responses, respectively.
Changying Jiang +10 more
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The actin nucleator Spir-1 is a virus restriction factor that promotes innate immune signalling.
PLoS Pathogens, 2022 Cellular proteins often have multiple and diverse functions. This is illustrated with protein Spir-1 that is an actin nucleator, but, as shown here, also functions to enhance innate immune signalling downstream of RNA sensing by RIG-I/MDA-5. In human and
Alice A Torres +6 more
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Autophagic machinery activated by dengue virus enhances virus replication
Virology, 2008 Autophagy is a cellular response against stresses which include the infection of viruses and bacteria. We unravel that Dengue virus-2 (DV2) can trigger autophagic process in various infected cell lines demonstrated by GFP-LC3 dot formation and increased LC3-II formation.
Lee, Ying-Ray +9 more
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Chronic Active Epstein–Barr Virus Disease [PDF]
Frontiers in Immunology, 2017 Chronic active Epstein-Barr virus (CAEBV) disease is a rare disorder in which persons are unable to control infection with the virus. The disease is progressive with markedly elevated levels of EBV DNA in the blood and infiltration of organs by EBV-positive lymphocytes. Patients often present with fever, lymphadenopathy, splenomegaly, EBV hepatitis, or
Hiroshi Kimura, Jeffrey I. Cohen
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Resting regulatory CD4 T cells: a site of HIV persistence in patients on long-term effective antiretroviral therapy. [PDF]
PLoS ONE, 2008 BACKGROUND: In HIV-infected patients on long-term HAART, virus persistence in resting long-lived CD4 T cells is a major barrier to curing the infection.
Tu-Anh Tran +11 more
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Inter-domain communication in SARS-CoV-2 spike proteins controls protease-triggered cell entry
Cell Reports, 2022 Summary: SARS-CoV-2 continues to evolve into variants of concern (VOC), with greatest variability in the multidomain, entry-facilitating spike proteins. To recognize the significance of adaptive spike protein changes, we compare variant SARS-CoV-2 virus ...
Enya Qing +7 more
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