Results 241 to 250 of about 3,262,736 (331)

Virus Assembly Pathways: Straying Away but Not Too Far. [PDF]

Small, 2020
Bond K, Tsvetkova IB, Wang JC, Jarrold MF, Dragnea B.   +4 more
europepmc   +1 more source

Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors.

Gastroenterology, 2014
D. McGivern, T. Masaki, Sara E. Williford, P. Ingravallo, Zongdi Feng, F. Lahser, E. Asante-Appiah, P. Neddermann, R. de Francesco, A. Howe, S. Lemon   +10 more
semanticscholar   +1 more source

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

Advanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao, Ruiqi Zhang, Rujun Wei, Huimin Fan, Yongfei Hu, Wenyu Shi, Jinfeng Wang   +6 more
wiley   +1 more source

Human Immunodeficiency Virus Type 1 Gag Polyprotein Modulates Membrane Physical Properties like a Surfactant: Potential Implications for Virus Assembly. [PDF]

ACS Infect Dis
Denieva ZG, Kuzmin PI, Galimzyanov TR, Datta SAK, Rein A, Batishchev OV.   +5 more
europepmc   +1 more source

HCV core protein and virus assembly: what we know without structures

Immunologic research, 2014
K. Gawlik, P. Gallay
semanticscholar   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Identification of a critical role for ZIKV capsid α3 in virus assembly and its genetic interaction with M protein. [PDF]

PLoS Negl Trop Dis
Jablunovsky A, Narayanan A, Jose J.
europepmc   +1 more source

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Cryo-ET of infected cells reveals that a succession of two lattices drives vaccinia virus assembly

, 2022
Hernandez-Gonzalez M, Calcraft T, Nans A, Rosenthal PB, Way M.   +4 more
europepmc   +1 more source