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Discovery of Dengue Virus Inhibitors
Current Medicinal Chemistry, 2020To date, there is still no approved anti-dengue agent to treat dengue infection in the market. Although the only licensed dengue vaccine, Dengvaxia is available, its protective efficacy against serotypes 1 and 2 of dengue virus was reported to be lower than serotypes 3 and 4.
Adib Afandi, Abdullah +9 more
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RNA virus discovery in insects
Current Opinion in Insect Science, 2015The advent of next generation sequencing (NGS) technology has allowed for significant advances in insect RNA virus discovery, particularly for identification of covert viruses and for identification of previously undescribed virus groups. Recent research has revealed the complexity and diversity both of viral populations within an insect, and of ...
Sijun, Liu +2 more
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Discovery of the hepatitis C virus
Liver International, 2009AbstractAfter nearly 6 years of intensive investigations between 1982 and 1988 in my laboratory at Chiron corporation, in which numerous molecular biological methods were used to investigate the viral aetiology of parenterally transmitted non‐A, non‐B viral hepatitis (NANBH), a single cDNA clone (5‐1‐1) was isolated that was shown to be derived from a ...
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2019
Official repository for the NCBI-Hackathon: Virus Discovery conducted January 2019 in San Diego (USA)
Ben Busby +2 more
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Official repository for the NCBI-Hackathon: Virus Discovery conducted January 2019 in San Diego (USA)
Ben Busby +2 more
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Ebola virus: from discovery to vaccine
Nature Reviews Immunology, 2003Ebola virus, being highly pathogenic for humans and non-human primates and the subject of former weapons programmes, is now one of the most feared pathogens worldwide. In addition, the lack of pre- and post-exposure interventions makes the development of rapid diagnostics, new antiviral agents and protective vaccines a priority for many nations ...
Heinz, Feldmann +3 more
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In Silico Drug Discovery for Treatment of Virus Diseases
2022Viral infections have remained a serious public health burden despite significant improvements in medical and pharmaceutical research in recent years. In silico approaches for drug discovery and design are fruitful for the management of a plethora of viral diseases. Virtual screening of libraries is performed using various computational tools to search
Shikha, Joon +2 more
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In silico approaches to Zika virus drug discovery
Expert Opinion on Drug Discovery, 2018After the WHO declared Zika virus (ZIKV) as a public health emergency of international concern, intense research for the development of vaccines and drugs has been undertaken, leading to the development of several candidates. Areas covered: This review discusses the developments achieved so far by computational methods in the discovery of candidate ...
Sinigaglia, Alessandro +3 more
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Beyond coronavirus: the virus discoveries transforming biology
Nature, 2021SARS-CoV-2 is just one of nonillions of viruses on our planet, and scientists are rapidly identifying legions of new species. SARS-CoV-2 is just one of nonillions of viruses on our planet, and scientists are rapidly identifying legions of new species.
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