Results 21 to 30 of about 294,058 (261)
Discovery of Dengue Virus NS4B Inhibitors [PDF]
Journal of Virology, 2015 ABSTRACT The four serotypes of dengue virus (DENV-1 to -4) represent the most prevalent mosquito-borne viral pathogens in humans. No clinically approved vaccine or antiviral is currently available for DENV. Here we report a spiropyrazolopyridone compound that potently inhibits DENV both in vitro and
Wang, Qing-Yin +21 more
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Discovery and Characterization of Novel Bat Coronavirus Lineages from Kazakhstan
Viruses, 2019 Coronaviruses are positive-stranded RNA viruses that infect a variety of hosts, resulting in a range of symptoms from gastrointestinal illness to respiratory distress.
Ian H. Mendenhall +7 more
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Viruses, 2023 Metagenomics has demonstrated its capability in outbreak investigations and pathogen surveillance and discovery. With high-throughput and effective bioinformatics, many disease-causing agents, as well as novel viruses of humans and animals, have been ...
Nathamon Kosoltanapiwat +14 more
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West Nile Virus Drug Discovery [PDF]
Viruses, 2013 The outbreak of West Nile virus (WNV) in 1999 in the USA, and its continued spread throughout the Americas, parts of Europe, the Middle East and Africa, underscored the need for WNV antiviral development. Here, we review the current status of WNV drug discovery.
Lim, S.P, Shi, P.-Y
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The search for meaning in virus discovery
Current Opinion in Virology, 2011 The rate of new virus discovery is increasing dramatically with improvements in sequencing and other molecular diagnostic platforms, and investments in sample collection and analysis. However, progress has been more limited in identification and implication of infectious agents that pose threats to human health and welfare.
Daszak, Peter, Lipkin, W Ian
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Hepatitis A Virus: From Discovery to Vaccines [PDF]
Hepatology, 2006 Hepatitis A virus (HAV), the causative agent of type A viral hepatitis, is an ancient human virus that was first identified almost 35 years ago. It has several characteristics that make it unique among the Picornaviridae
Annette, Martin, Stanley M, Lemon
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Isolation and Characterization of a Novel Gammaherpesvirus from a Microbat Cell Line
mSphere, 2016 While employing deep sequencing and de novo assembly to characterize the mRNA transcript profile of a cell line derived from the microbat Myotis velifer incautus, we serendipitously identified mRNAs encoding proteins with a high level of identity to ...
Reed S. Shabman +11 more
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Metagenomics and future perspectives in virus discovery [PDF]
Current Opinion in Virology, 2012 Monitoring the emergence and re-emergence of viral diseases with the goal of containing the spread of viral agents requires both adequate preparedness and quick response. Identifying the causative agent of a new epidemic is one of the most important steps for effective response to disease outbreaks.
Mokili, J.L., Rohwer, F., Dutilh, B.E.
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Viruses, 2023 Upon the sudden death of two captive roan antelopes (Hippotragus equinus) that had suffered from clinical signs reminiscent of malignant catarrhal fever (MCF) in a German zoo, next generation sequencing of organ samples provided evidence of the presence ...
Franziska Karola Kaiser +8 more
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Diagnostics, 2021 In recent years, refined molecular methods coupled with powerful high throughput sequencing technologies have increased the potential of virus discovery in clinical samples.
Alba Folgueiras-González +4 more
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