Results 111 to 120 of about 3,649,227 (295)

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Discovery and characterization of complete genomes of 38 head-tailed proviruses in four predominant phyla of archaea

Microbiology Spectrum
Archaea play a significant role in natural ecosystems and the human body. Archaeal viruses exert a considerable influence on the structure and composition of archaeal communities and their associated ecological environments.
Tianqi Xu, Yimin Ni, Hailing Li, Shuang Wu, Shuling Yan, Lanming Chen, Yongxin Yu, Yongjie Wang   +7 more
doaj   +1 more source

Attenuated live vaccine usage affects accurate measures of virus diversity and mutation rates in avian coronavirus infectious bronchitis virus

Virus Research, 2011
Highlights ► Positive selection was not observed for IBV types where live vaccines are used. ► Positive selection was observed for IBV types where no vaccines exist. ► Seven recombination breakpoints sere observed distributed across the genome. ► Viruses
Enid T McKinley, M. Jackwood, D. Hilt, J. Kissinger, Jon S. Robertson, C. Lemke, A. Paterson   +6 more
semanticscholar   +1 more source

Deep Learning–Assisted Differentiation of Four Peripheral Neuropathies Using Corneal Confocal Microscopy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah, Ioannis N. Petropoulos, Mark Stettner, Maryam Ferdousi, Uazman Alam, Nathan Efron, Ahmed Serag, Rayaz A. Malik   +7 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Limited evolution of the yellow fever virus 17d in a mouse infection model

Emerging Microbes and Infections, 2019
By infecting mice with the yellow fever virus vaccine strain 17D (YFV-17D; Stamaril®), the dose dependence and evolutionary consequences of neurotropic yellow fever infection was assessed.
Dieudonné Buh Kum, Niraj Mishra, Bram Vrancken, Hendrik Jan Thibaut, Annelies Wilder-Smith, Philippe Lemey, Johan Neyts, Kai Dallmeier   +7 more
doaj   +1 more source

Simian T-Lymphotropic Virus Diversity among Nonhuman Primates, Cameroon

Emerging Infectious Diseases, 2009
Broad virus diversity warrants active monitoring for cross-species transmission and highlights the risk for human disease.
D. Sintasath, N. Wolfe, M. Lebreton, Hongwei Jia, Albert Garcia, J. Diffo, U. Tamoufe, J. Carr, T. Folks, E. Mpoudi-Ngolé, D. Burke, W. Heneine, W. Switzer   +12 more
semanticscholar   +1 more source

Effects of Biological Sex and Age on Cerebrospinal Fluid Markers—A Retrospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebrospinal fluid (CSF) analysis is a key diagnostic tool for neurological diseases. To date, only a few studies have investigated in larger cohorts the effect of age and biological sex on diagnostic markers extracted from CSF. Methods For this retrospective observational study, 4163 CSF findings (2012–2020) were evaluated.
Isabel‐Sophie Hafer, Simon Faissner, Ralf Gold, Aiden Haghikia   +3 more
wiley   +1 more source

Global distributions and strain diversity of avian infectious bronchitis virus: a review

Animal Health Research Reviews, 2017
The poultry industry faces challenge amidst global food security crisis. Infectious bronchitis is one of the most important viral infections that cause huge economic loss to the poultry industry worldwide. The causative agent, infectious bronchitis virus
F. Bande, S. Arshad, A. Omar, M. Hair-Bejo, A. Mahmuda, V. Nair   +5 more
semanticscholar   +1 more source

Genomic analysis of diverse rubella virus genotypes

Journal of General Virology, 2007
Based on the sequence of the E1 glycoprotein gene, two clades and ten genotypes ofRubella virushave been distinguished; however, genomic sequences have been determined for viruses in only two of these genotypes. In this report, genomic sequences for viruses in an additional six genotypes were determined. The genome was found to be well conserved.
Yumei, Zhou, Hiroshi, Ushijima, Teryl K, Frey   +2 more
openaire   +2 more sources