Results 21 to 30 of about 2,624 (181)
mBio, 2022 Transmission of the New World hemorrhagic fever arenaviruses Junín virus (JUNV) and Machupo virus (MACV) to humans is facilitated, in part, by the interaction between the arenavirus GP1 glycoprotein and the human transferrin receptor 1 (hTfR1).
Weng M. Ng +9 more
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Structural basis for recognition and regulation of arenavirus polymerase L by Z protein
Nature Communications, 2021 Junin virus (JUNV) causes Argentine hemorrhagic fever and encodes the large protein (L) of the RNA dependent RNA polymerase (RdRp) and its regulator, the matrix zinc-binding protein (Z).
Huiling Kang +8 more
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Антибиотики и Химиотерапия, 2023 The article presents an analysis of studies assessing the effectiveness of new nonspecific medications against hemorrhagic fevers caused by arenaviruses.
Т. Е. Sizikova +2 more
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Crystal structure of Junin virus nucleoprotein
Journal of General Virology, 2013 Junin virus (JUNV) has been identified as the aetiological agent of Argentine haemorrhagic fever (AHF), which is a serious public health problem with approximately 5 million people at risk. It is treated as a potential bioterrorism agent because of its rapid transmission by aerosols.
Yinjie, Zhang +8 more
openaire +2 more sources
Review of Mammarenavirus Biology and Replication
Frontiers in Microbiology, 2018 The family Arenaviridae is divided into three genera: Mammarenavirus, Reptarenavirus, and Hartmanivirus. The Mammarenaviruses contain viruses responsible for causing human hemorrhagic fever diseases including New World viruses Junin, Machupo, Guanarito ...
Steven J. Hallam +3 more
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Tacaribe virus but not junin virus infection induces cytokine release from primary human monocytes and macrophages. [PDF]
PLoS Neglected Tropical Diseases, 2011 The mechanisms underlying the development of disease during arenavirus infection are poorly understood. However, common to all hemorrhagic fever diseases is the involvement of macrophages as primary target cells, suggesting that the immune response in ...
Allison Groseth +6 more
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The entry of Junin virus into Vero cells [PDF]
Archives of Virology, 1994 The entry mechanism of Junin virus (JV) into Vero cells was studied analyzing the effect of lysosomotropic compounds and acid pH on JV infection. Ammonium chloride, amantadine, chlorpheniramine and procaine inhibited JV production. The action of ammonium chloride was exerted at early times of infection.
Castilla, V. +3 more
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Antigen vehiculization particles based on the Z protein of Junin virus
BMC Biotechnology, 2012 Background Arenavirus matrix protein Z plays an important role in virus budding and is able to generate enveloped virus-like-particles (VLPs) in absence of any other viral proteins.
Borio Cristina S +6 more
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Nature Communications, 2018 The five known New World hemorrhagic fever arenaviruses use the same entry receptor, but their viral glycoproteins are markedly different. Here, the authors isolate monoclonal antibodies from a Junin virus vaccinated person that cross-neutralize Machupo ...
Lars E. Clark +12 more
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Potential and action mechanism of favipiravir as an antiviral against Junin virus.
PLoS Pathogens, 2022 Favipiravir is a nucleoside analogue that inhibits the replication and transcription of a broad spectrum of RNA viruses, including pathogenic arenaviruses.
Vahid Rajabali Zadeh +4 more
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