Results 31 to 40 of about 1,043,974 (224)

Monoclonal antibody therapy for Junin virus infection [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance There are no Food and Drug Administration approved drugs available for preventing or treating Argentine hemorrhagic fever (AHF), and the current treatment option is limited to administration of immune plasma. With the expanding clinical use of monoclonal antibodies (mAbs) for acute and chronic conditions, it has become ...
Larry, Zeitlin, Joan B, Geisbert, Daniel J, Deer, Karla A, Fenton, Ognian, Bohorov, Natasha, Bohorova, Charles, Goodman, Do, Kim, Andrew, Hiatt, Michael H, Pauly, Jesus, Velasco, Kevin J, Whaley, Friedrich, Altmann, Clemens, Gruber, Herta, Steinkellner, Anna N, Honko, Ana I, Kuehne, M Javad, Aman, Sara, Sahandi, Sven, Enterlein, Xiaoguo, Zhan, Delia, Enria, Thomas W, Geisbert   +22 more
openaire   +2 more sources

New transmission scenarios of the argentine hemorrhagic fever since the introduction of the live attenuated junin virus vaccine (candid #1): an experience in migrant workers

Revista Peruana de Medicina Experimental y Salud Pública, 2015
The Argentine hemorrhagic fever (AHF) is a severe acute viral disease caused by the Junin virus of the Arenaviridae family. The AHF endemic area coincides geographically with the largest grain export agro-industrial complex of the country [Argentina ...
Ana Briggiler, Anabel Sinchi, Florencia Coronel, Zaida Sánchez, Silvana Levis, Jorge Taylor, Delia Enria   +6 more
doaj   +1 more source

Effective oral favipiravir (T-705) therapy initiated after the onset of clinical disease in a model of arenavirus hemorrhagic Fever. [PDF]

PLoS Neglected Tropical Diseases, 2011
Lassa and Junín viruses are the most prominent members of the Arenaviridae family of viruses that cause viral hemorrhagic fever syndromes Lassa fever and Argentine hemorrhagic fever, respectively.
Michelle Mendenhall, Andrew Russell, Donald F Smee, Jeffery O Hall, Ramona Skirpstunas, Yousuke Furuta, Brian B Gowen   +6 more
doaj   +1 more source

Nuclease Activity of the Junín Virus Nucleoprotein C-Terminal Domain

Viruses, 2023
The mammarenavirus Junín (JUNV) is the causative agent of Argentine hemorrhagic fever, a severe disease of public health concern. The most abundant viral protein is the nucleoprotein (NP), a multifunctional, two-domain protein with the primary role as ...
Alicia Armella Sierra, María Eugenia Loureiro, Sebastián Esperante, Silvia Susana Borkosky, Giovanna L. Gallo, Gonzalo de Prat Gay, Nora Lopez   +6 more
doaj   +1 more source

Human Hemorrhagic Fever Causing Arenaviruses: Molecular Mechanisms Contributing to Virus Virulence and Disease Pathogenesis

Pathogens, 2015
Arenaviruses include multiple human pathogens ranging from the low-risk lymphocytic choriomeningitis virus (LCMV) to highly virulent hemorrhagic fever (HF) causing viruses such as Lassa (LASV), Junin (JUNV), Machupo (MACV), Lujo (LUJV), Sabia (SABV ...
Junjie Shao, Yuying Liang, Hinh Ly
doaj   +1 more source

Single dose rVSVΔG-JUNVGP vaccine protects guinea pigs against lethal Junin virus challenge

npj Vaccines, 2021
Junin virus (JUNV) is a pathogen of biodefense importance due to its potential for aerosol transmission and mortality rates reaching 30%. Currently, there are no JUNV vaccines licensed by the United States Food and Drug Administration (FDA) for at-risk ...
Teresa E. Sorvillo, Robert W. Cross, Dylan M. Johnson, Natalie S. Dobias, Karla A. Fenton, Chad E. Mire, Thomas W. Geisbert   +6 more
doaj   +1 more source

Junin Virus Infection in Genetically Athymic Mice

Intervirology, 1983
The progression of Junin virus infection was studied in congenitally athymic mice. Immunocompetent littermates were used as infected controls. As expected, the latter developed lethal encephalitis, with viremia and considerable viral replication in the brain.
M C, Weissenbacher, M A, Calello, C J, Quintans, H, Panisse, N M, Woyskowsky, V H, Zannoli   +5 more
openaire   +2 more sources

Immunosuppression in Experimental Junin Virus Infection of Mice

Intervirology, 1980
The effects of cyclophosphamide (CY), anti-mouse thymocyte sera, oxisuran, and cytosine arabinoside were evaluated in adult and newborn mice infected with Junin virus. Treatment with CY was the most effective, Adult mice, which are not normally susceptible to intracerebral infection with 10(3) LD50 of Junin virus, were rendered susceptible by treatment
O A, Giovanniello, M R, Nejamkis, N V, Galassi, N R, Nota   +3 more
openaire   +2 more sources

Multifaceted Small Molecules as Enzyme Modulators: Cases of Drug Discovery/Repurposing Illustrating Nature′s Pragmatism

BioMed Research International, Volume 2026, Issue 1, 2026.
The cross‐reactivity of substrates, modulators with other enzymes significantly reduces/prevents our ability to design such highly specific, that is, “one warhead–one target”, modulators. On the other hand, the potential “impasse” fuels repurposing of already developed drugs.
Monika I. Konaklieva, Balbina J. Plotkin, Nahit Gencer   +2 more
wiley   +1 more source

Junin virus‐induced astrocytosis is impaired by iNOS inhibition

Journal of Medical Virology, 2002
AbstractBecause Junin virus (JV) experimental encephalitis of mice and rats is characterized by mild histopathological changes that do not seem to justify per se lethality after intracerebral infection, such a murine model seems adequate to investigate the potential role of inducible nitric oxide synthase (iNOS) as a pathogenic factor. Concomitant with
Gomez, Ricardo Martin, Yep, Alejandra, Schattner, Mirta Ana, Berria, Maria Isabel   +3 more
openaire   +3 more sources