Results 21 to 30 of about 3,174 (230)
Antigen vehiculization particles based on the Z protein of Junin virus
BMC Biotechnology, 2012 Background Arenavirus matrix protein Z plays an important role in virus budding and is able to generate enveloped virus-like-particles (VLPs) in absence of any other viral proteins.
Borio Cristina S +6 more
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Replication of Junin Virus in the Presence of Tunicamycin
Intervirology, 1984 In the presence of tunicamycin (TM), an antibiotic which inhibits glycosylation, Junin virus-infected cells released 70% as much virus as control cultures, as measured by [35S]-methionine appearing in a sucrose gradient virus particle fraction. In this same fraction, the incorporation of [14C]-glucosamine was inhibited 85% by TM, accompanied by a ...
P J, Padula, Z M, de Martínez Segovia
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Review of Mammarenavirus Biology and Replication
Frontiers in Microbiology, 2018 The family Arenaviridae is divided into three genera: Mammarenavirus, Reptarenavirus, and Hartmanivirus. The Mammarenaviruses contain viruses responsible for causing human hemorrhagic fever diseases including New World viruses Junin, Machupo, Guanarito ...
Steven J. Hallam +3 more
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Frontiers in Microbiology, 2021 Ebola virus infection causes severe hemorrhagic fever, and its mortality rates varied from 25 to 90% in the previous outbreaks. The highly infectious and lethal nature of this virus highlights the need for reliable and sensitive diagnostic methods to ...
Wenwu Yao +5 more
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Monoclonal antibody therapy for Junin virus infection [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance There are no Food and Drug Administration approved drugs available for preventing or treating Argentine hemorrhagic fever (AHF), and the current treatment option is limited to administration of immune plasma. With the expanding clinical use of monoclonal antibodies (mAbs) for acute and chronic conditions, it has become ...
Larry, Zeitlin +22 more
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Nature Communications, 2018 The five known New World hemorrhagic fever arenaviruses use the same entry receptor, but their viral glycoproteins are markedly different. Here, the authors isolate monoclonal antibodies from a Junin virus vaccinated person that cross-neutralize Machupo ...
Lars E. Clark +12 more
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Tacaribe virus but not junin virus infection induces cytokine release from primary human monocytes and macrophages. [PDF]
PLoS Neglected Tropical Diseases, 2011 The mechanisms underlying the development of disease during arenavirus infection are poorly understood. However, common to all hemorrhagic fever diseases is the involvement of macrophages as primary target cells, suggesting that the immune response in ...
Allison Groseth +6 more
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In vitro infection of murine macrophages with Junin virus [PDF]
Infection and Immunity, 1982 Mouse peritoneal macrophages were successfully infected with two strains of Junin virus producing high titers with no apparent cell damage. Infected cultures survived longer than noninfected cultures. The pattern of virus release suggested a persistent infection.
P H, González +3 more
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Potential and action mechanism of favipiravir as an antiviral against Junin virus.
PLoS Pathogens, 2022 Favipiravir is a nucleoside analogue that inhibits the replication and transcription of a broad spectrum of RNA viruses, including pathogenic arenaviruses.
Vahid Rajabali Zadeh +4 more
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Crystal structure of Junin virus nucleoprotein
Journal of General Virology, 2013 Junin virus (JUNV) has been identified as the aetiological agent of Argentine haemorrhagic fever (AHF), which is a serious public health problem with approximately 5 million people at risk. It is treated as a potential bioterrorism agent because of its rapid transmission by aerosols.
Yinjie, Zhang +8 more
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