Results 51 to 60 of about 1,043,974 (224)

Potent inhibition of Junín virus infection by interferon in murine cells. [PDF]

PLoS Neglected Tropical Diseases, 2014
The new world arenavirus Junín virus (JUNV) is the causative agent of Argentine hemorrhagic fever, a lethal human infectious disease. Adult laboratory mice are generally resistant to peripheral infection by JUNV.
Cheng Huang, Aida G Walker, Ashley M Grant, Olga A Kolokoltsova, Nadezhda E Yun, Alexey V Seregin, Slobodan Paessler   +6 more
doaj   +1 more source

Evaluating the Potential Adverse Effects of Favipiravir on Biochemical, Histopathological, and Spermatological Parameters in Male Rats' Testicular Tissue

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 6, June 2025.
ABSTRACT Favipiravir is a selective RNA polymerase inhibitor and a broad‐spectrum antiviral drug. Favipiravir reduces cell proliferation by inhibiting RNA transcription, particularly in rapidly proliferating cells such as spermatogonia. The aim of this study was to investigate the effects and mechanism of action of favipiravir (T‐705) on sperm quality ...
Ali Doğan Ömür, Gamze Uçak, Adem Kara, Elif Erbaş, Serkan Ali Akarsu, Seçkin Özkanlar, Nevra Aydemir Celep   +6 more
wiley   +1 more source

EXPERIENCE OF STUDY AND POSSIBLE WAYS OF ELIMINATION OF FALSE POSITIVE AND FALSE NEGATIVE RESULTS DURING EXECUTION OF POLYMERASE CHAIN REACTION ON AN EXAMPLE OF JUNIN VIRUS RNA DETECTION

Журнал микробиологии, эпидемиологии и иммунобиологии, 2015
Aim. Experience of study and possible ways of elimination of false positive and false negative results during execution of polymerase chain reaction on an example of Junin virus RNA detection. Materials and methods.
T. E Sizikova, V. N Lebedev, V. B Pantyukhov, S. V Borisevich, V. A Merkulov   +4 more
doaj  

Junin Virus Triggers Macrophage Activation and Modulates Polarization According to Viral Strain Pathogenicity

Frontiers in Immunology, 2019
The New World arenavirus Junin (JUNV) is the etiological agent of Argentine hemorrhagic fever (AHF). Previous studies of human macrophage infection by the Old-World arenaviruses Mopeia and Lassa showed that while the non-pathogenic Mopeia virus ...
María F. Ferrer, Pablo Thomas, Aída O. López Ortiz, Aída O. López Ortiz, Andrea E. Errasti, Nancy Charo, Victor Romanowski, Victor Romanowski, Juan Gorgojo, María E. Rodriguez, Eugenio A. Carrera Silva, Ricardo M. Gómez, Ricardo M. Gómez   +12 more
doaj   +1 more source

Involvement of the cytoskeleton in Junin virus multiplication.

Journal of General Virology, 1999
The role of the cellular cytoskeleton in Junin virus (JV) infection was explored in two ways. Firstly, the action of inhibitors that affect individual cytoskeletal systems (microtubules or microfilaments) selectively was analysed. It was found that perturbations of microtubule or microfilament networks caused by colchicine, nocodazole, nifedipine, EGTA
N A, Candurra, M J, Lago, L, Maskin, E B, Damonte   +3 more
openaire   +2 more sources

Two Birds With One Stone: RNA Virus Strategies to Manipulate G3BP1 and Other Stress Granule Components

WIREs RNA, Volume 16, Issue 2, March/April 2025.
Stress granules emerging during viral infection can play both pro‐ and antiviral roles. RNA viruses use various strategies to antagonize their formation, including the degradation, inhibition, or sequestration of G3BP1, a key stress granule protein. However, biochemical and structural insights into these mechanisms have been reported for only a handful
Moh Egy Rahman Firdaus, Eliana Dukhno, Rupali Kapoor, Piotr Gerlach   +3 more
wiley   +1 more source

Exploring the druggability of the UEV domain of human TSG101 in search for broad‐spectrum antivirals

Protein Science, Volume 34, Issue 1, January 2025.
Abstract The ubiquitin E2 variant domain of TSG101 (TSG101‐UEV) plays a pivotal role in protein sorting and virus budding by recognizing PTAP motifs within ubiquitinated proteins. Disruption of TSG101‐UEV/PTAP interactions has emerged as a promising strategy for the development of host‐oriented broad‐spectrum antivirals with low susceptibility to ...
Fernando Montero, Marisa Parra‐López, Alejandro Rodríguez‐Martínez, Javier Murciano‐Calles, Pedro Buzon, Ziying Han, L.‐Y. Lin, Maria C. Ramos, Javier Ruiz‐Sanz, Jose C. Martinez, Marco Radi, Christiane Moog, Sandra Diederich, Ronald N. Harty, Horacio Pérez‐Sánchez, Francisca Vicente, Francisco Castillo, Irene Luque   +17 more
wiley   +1 more source

Phytochemical Analysis and Pharmaceutical Applications of Monoterpenoids Present in the Essential Oil of Boswellia sacra (Omani Luban)

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2025, Issue 1, 2025.
Due to its intricacy and long‐term usefulness, traditional medicine continues to be practiced in several nations. Among the many medicinal plants found in the Dhofar region of Oman, the aromatic oleo‐gum resin generated by Boswellia sacra, commonly referred to as frankincense, stands out for its medical and commercial significance. Resin‐carrying ducts
Foziya Khan, Luay Rashan, Kuldeep Singh
wiley   +1 more source

National Seroprevalence and Risk Factors of Bluetongue Virus in Domestic Ruminants of Peru

Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.
Bluetongue (BT) is a viral infection caused by the bluetongue virus (BTV) that affects domestic and wild ruminants worldwide. It is primarily transmitted by Culicoides spp. midges, and its infection is highly prevalent across temperate and tropical regions.
Dennis A. Navarro-Mamani, Jessica Jurado, Ana Vargas-Calla, Kevin Ponce, Tyler Sherman, Yari Zarate, César A. Murga-Moreno, Ibelice Perez, Ruben Villacaqui, Miguel Ara, Pedro Ortiz, Hermelinda Rivera, Christie E. Mayo, Fedor Korennoy   +13 more
wiley   +1 more source

A One Health approach for South American hemorrhagic fevers

CABI One Health
South American hemorrhagic fevers (SAHF) include five rodent-borne New World mammarenaviruses. These are Junin, Machupo, Chapare, Guanarito, and Sabia viruses.
Dr Rory Wilson, Dr Ariella Barry
doaj   +1 more source