Results 81 to 90 of about 75,185 (247)

THE MOLECULAR MECHANISMS OF EPSTEINBARR VIRUS PERSISTENCE IN THE HUMAN ORGANISM [PDF]

Annals of Mechnikov's Institute, 2014
This review describes advances in molecular aspects of EBV infection and disease. We discuss the spectrum of clinical illness due to EBV persistent infection.
Volyanskiy A.Yu., Kolotova T.Yu., Romanova E.A., Sidorenko T.A., Igumnova N.I., Konoreva E.S., Yukhimenko V.I., Kabluchko T.V., Pogorila M.S.   +8 more
doaj  

SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics

Advanced Science, EarlyView.
ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods. To address this, we propose SpatialESD, a Spatial
Hongyan Cao, Gaiqin Liu, Jingyi Xia, Runle Chen, Tong Wang, Xiaoling Yang, Ruiling Fang, Yanhong Luo, Ping Zeng, Hongmei Yu, Yanbo Zhang, Yuehua Cui   +11 more
wiley   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Acute HSV-1 Ocular Infection Is Impaired in KLF15 Knockout Mice but Stress-Induced Reactivation from Latency Is Prolonged in Male KLF15 Knockout Mice

Pathogens
Acute human alpha-herpesvirus 1 (HSV-1) infection culminates in a latent infection of neurons in trigeminal ganglia (TG) and the central nervous system.
Kelly S. Harrison, Clinton Jones
doaj   +1 more source

Key questions on the epigenetics of herpes simplex virus latency. [PDF]

PLoS Pathog, 2022
Whitford AL, Cliffe AR.
europepmc   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

The molecular mechanisms of Epstein-Barr virus persistence in the human organism

Annals of Mechnikov's Institute, 2020
This review describes advances in molecular aspects of EBV infection and disease. We discuss the spectrum of clinical illness due to EBV persistent infection.
A Volyanskiy, T Kolotova, E Romanova, T Sidorenko, N Igumnova, E Konoreva, V Yukhimenko, T Kabluchko, M Pogorila   +8 more
doaj  

Herpes simplex virus type-1 latency inhibits dendritic growth in sympathetic neurons

Neurobiology of Disease, 2006
Herpes simplex virus type-1 (HSV-1) initially infects mucoepithelial tissues of the orofacial region, the eye and to a lesser extent the genitalia. Subsequently, the virus is retrogradely transported through the axons of the sensory and sympathetic ...
Mohamed A. Hamza, Dennis M. Higgins, William T. Ruyechan   +2 more
doaj   +1 more source

IFI16 Partners with KAP1 to Maintain Epstein-Barr Virus Latency. [PDF]

J Virol, 2022
Xu H, Li X, Rousseau BA, Akinyemi IA, Frey TR, Zhou K, Droske LE, Mitchell JA, McIntosh MT, Bhaduri-McIntosh S.   +9 more
europepmc   +1 more source

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis

Advanced Science, EarlyView.
Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang, Linlin Xu, Chenglong Pan, Ruonan Cao, Piao Zeng, Xinxing Lyu, Qingxia Hu, Zhenzhen Yan, Shuhong Huang, Ningning Dang   +9 more
wiley   +1 more source