Evaluation in Swine of a Recombinant Georgia 2010 African Swine Fever Virus Lacking the I8L Gene
Viruses, 2020 African swine fever virus (ASFV) is the causative agent of African swine fever, a disease currently causing significant economic losses in Europe and Asia. Specifically, the highly virulent ASFV strain Georgia 2010 (ASFV-G) is producing disease outbreaks
Elizabeth Vuono +9 more
doaj +1 more source
Mouse-adapted H9N2 influenza A virus PB2 protein M147L and E627K mutations are critical for high virulence. [PDF]
PLoS ONE, 2012 H9N2 influenza viruses have been circulating worldwide in multiple avian species and have repeatedly infected humans to cause typical disease. The continued avian-to-human interspecies transmission of H9N2 viruses raises concerns about the possibility of
Jingjing Wang +7 more
doaj +1 more source
Egyptian Journal of Biological Pest Control, 2022 Background Baculoviruses are significant biocontrol agents of pests in agriculture; however, ultraviolet light B (UV-B) and high temperature inactivate them in the environment within a short time.
Gozde Busra Eroglu, Zihni Demırbag
doaj +1 more source
Passaging of a Newcastle disease virus pigeon variant in chickens results in selection of viruses with mutations in the polymerase complex enhancing virus replication and virulence [PDF]
, 2010 Some Newcastle disease virus (NDV) variants isolated from pigeons (pigeon paramyxovirus type 1; PPMV-1) do not show their full virulence potential for domestic chickens but may become virulent upon spread in these animals.
Dortmans, J.C.F.M. +3 more
core +2 more sources
Is HIV short-sighted? Insights from a multistrain nested model [PDF]
, 2013 An important component of pathogen evolution at the population level is evolution within hosts. Unless evolution within hosts is very slow compared to the duration of infection, the composition of pathogen genotypes within a host is likely to change ...
Fraser, Christophe +2 more
core +3 more sources
Wolbachia versus dengue: Evolutionary forecasts. [PDF]
, 2013 A novel form of biological control is being applied to the dengue virus. The agent is the maternally transmitted bacterium Wolbachia, naturally absent from the main dengue vector, the mosquito Aedes aegypti.
Bull, James J, Turelli, Michael
core +1 more source
Adaption of seasonal H1N1 influenza virus in mice. [PDF]
PLoS ONE, 2011 The experimental infection of a mouse lung with influenza A virus has proven to be an invaluable model for studying the mechanisms of viral adaptation and virulence.
Lili Xu +12 more
doaj +1 more source
Mutations in the Schmallenberg virus Gc glycoprotein facilitate cellular protein synthesis shutoff and restore pathogenicity of NSs deletion mutants in mice [PDF]
, 2016 Serial passage of viruses in cell culture has been traditionally used to attenuate virulence and identify determinants of viral pathogenesis. In a previous study, we found that a strain of Schmallenberg virus (SBV) serially passaged in tissue culture ...
Aislynn Taggart +13 more
core +1 more source
Estudio genómico de cepas argentinas de Herpesvirus equino 1 [PDF]
, 2011 La infección por Herpesvirus equino 1 (EHV-1) tiene un significativo impacto económico en la producción equina mundial al causar abortos, enfermedad respiratoria, muertes perinatales y desórdenes neurológicos.
Eöry, Matías Leonel +5 more
core +2 more sources
Roadblocks to translational challenges on viral pathogenesis. [PDF]
, 2013 Distinct roadblocks prevent translating basic findings in viral pathogenesis into therapies and implementing potential solutions in the clinic. An ongoing partnership between the Volkswagen Foundation and Nature Medicine resulted in an interactive ...
Deeks, Steven +4 more
core +1 more source