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Virus shedding kinetics and unconventional virulence tradeoffs
PLOS Pathogens, 2021 Tradeoff theory, which postulates that virulence provides both transmission costs and benefits for pathogens, has become widely adopted by the scientific community. Although theoretical literature exploring virulence-tradeoffs is vast, empirical studies validating various assumptions still remain sparse.
Andrew R. Wargo +3 more
openaire +4 more sources
The relationship of within-host multiplication and virulence in a plant-virus system. [PDF]
PLoS ONE, 2007 Virulence does not represent any obvious advantage to parasites. Most models of virulence evolution assume that virulence is an unavoidable consequence of within-host multiplication of parasites, resulting in trade-offs between within-host multiplication
Israel Pagán +2 more
doaj +1 more source
Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence [PDF]
, 2005 Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses.
Bartlett, Nathan W +8 more
core +3 more sources
Molecular basis for a lack of correlation between viral fitness and cell killing capacity. [PDF]
PLoS Pathogens, 2007 The relationship between parasite fitness and virulence has been the object of experimental and theoretical studies often with conflicting conclusions. Here, we provide direct experimental evidence that viral fitness and virulence, both measured in the ...
Mónica Herrera +4 more
doaj +1 more source
Identification of an essential virulence gene of cyprinid herpesvirus 3 [PDF]
, 2017 The genus Cyprinivirus consists of a growing list of phylogenetically related viruses, some of which cause severe economic losses to the aquaculture industry. The archetypal member, cyprinid herpesvirus 3 (CyHV-3) causes mass mortalities worldwide in koi
Boutier, Maxime +5 more
core +2 more sources
Re-Assembly and Analysis of an Ancient Variola Virus Genome
Viruses, 2017 We report a major improvement to the assembly of published short read sequencing data from an ancient variola virus (VARV) genome by the removal of contig-capping sequencing tags and manual searches for gap-spanning reads. The new assembly, together with
Chad Smithson, Jacob Imbery, Chris Upton
doaj +1 more source
Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]
, 2011 Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle +3 more
core +2 more sources
Determinants of virulence of influenza A virus [PDF]
European Journal of Clinical Microbiology & Infectious Diseases, 2013 Influenza A viruses cause yearly seasonal epidemics and occasional global pandemics in humans. In the last century, four human influenza A virus pandemics have occurred. Occasionally, influenza A viruses that circulate in other species cross the species barrier and infect humans. Virus reassortment (i.e. mixing of gene segments of multiple viruses) and
Schrauwen, Eefje +5 more
openaire +2 more sources
PLoS Neglected Tropical Diseases, 2021 Rift Valley fever virus (RVFV) is a mosquito-borne bunyavirus with a wide host range including ruminants and humans. RVFV outbreaks have had devastating effects on public health and the livestock industry in African countries.
Kaori Terasaki +7 more
doaj +1 more source
Virulence of H5N1 virus in mice attenuates after
Virology Journal, 2011 The virulence of A/Vietnam/1194/2004 (VN1194) in mice attenuated after serial passages in MDCK cells and chicken embryos, because the enriched large-plaque variants of the virus had significantly reduced virulence.
Li Yongqiang +8 more
doaj +1 more source