Results 61 to 70 of about 3,777,037 (252)

Encapsulated Leptin‐Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates

Advanced Science, EarlyView.
A clinically translatable cell line can be engineered to produce leptin, encapsulated in biomaterial and safely implanted to produce and deliver the metabolic regulating protein within the body. Implantation of these encapsulated cells decreases the time it takes for mice and non‐human primates to adjust to circadian disruptions similar to those ...
Samantha T. Fleury, Xuanyi Lin, Peter D. Rios, Christopher Olker, Eun Joo Song, Alejandra Cobos Perez, Cody Fell, Daisy Lopez, Ira Joshi, Hafsa Nasir, Cecelia Curtis, Danna Muringi, Kaiyuan Wang, José Oberholzer, Fred W. Turek, Isaac B. Hilton, Jonathan Rivnay, Martha Hotz Vitaterna, Omid Veiseh   +18 more
wiley   +1 more source

AI‐Assisted Tumor Boundary Delineation via Targeted Ultrasmall Iron Oxide Nanoprobe for High‐Contrast HER2‐Positive Tumor Imaging

Advanced Science, EarlyView.
A novel targeted and pH‐responsive MRI contrast agent was integrated with a 3D nnU‐Net deep learning framework to enable accurate delineation of tumor boundary morphology in HER2‐positive breast cancer imaging. ABSTRACT Breast cancer continues to be a leading cause of cancer‐related mortality in women globally, where precise diagnosis and clear tumor ...
Jiaying Zheng, Yi Zhu, Xinrui Li, Sunxian Dai, Xiangyuan Ma, Hongwei Lu, Zhongling Wang, Benqing Zhou   +7 more
wiley   +1 more source

Quantitative magnetic resonance imaging (MRI) evaluation of visceral and hepatic fat in Cushing’s syndrome: insights into cortisol-driven metabolic changes [PDF]

Archives of Endocrinology and Metabolism
Objective: To quantify hepatic steatosis and visceral adiposity in active Cushing’s syndrome (CS) using magnetic resonance imaging (MRI), evaluate associations between hypercortisolism and MRI-derived fat metrics, and characterize the relationship ...
Rania Naguib, Marwa Ahmed Salah Ahmed, Sherif Mohamed Elsharkawi, Hany A. Elkattawy, Mohamed Ahmed Hassan, Hend Naguib   +5 more
doaj   +2 more sources

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Adiposity in British secondary school children: a population based study

, 2008
Summary:Adiposity is defined as the property of containing fat. Excessive adiposity is a cause of both morbidity and mortality in adults. Important consequences include increased risks of type 2 diabetes, coronary heart disease and stroke, (particularly ...
Odoki, Katherine Helen
core   +1 more source

Visceral Adiposity Index and Chronic Kidney Disease in a Non-Diabetic Population: A Cross-Sectional Study

Diabetes, Metabolic Syndrome and Obesity, 2020
Hua Xiao,* Chongxiang Xiong,* Xiaofei Shao,* Peichun Gao, Haishan Chen, Jing Ning, Yunying Chen, Ziliang Zou, Guobao Hong, Xiaolin Li, Xu You, Jieli Sheng, Fan Wu, Xin Wang, Hequn Zou Department of Nephrology, The Third Affiliated Hospital, Southern ...
Xiao H, Xiong C, Shao X, Gao P, Chen H, Ning J, Chen Y, Zou Z, Hong G, Li X, You X, Sheng J, Wu F, Wang X, Zou H   +14 more
doaj  

Is the visceral adiposity index associated with the presence of cardiovascular risk scores and comorbidity in psoriatic disease? [PDF]

Objective: The aim of this study was to evaluate the relationship between cardiovascular risk scores and the visceral adiposity index (VAI) in patients with psoriatic disease (PsD).
ERDEN, ABDULSAMET, OMMA, AHMET, Adem Özkara, ERDEN, FATMA, Sevinç Can Sandıkçı, Tülay Omma, Can Sandıkçı, Sevinç, OMMA, TÜLAY, Abdülsamet Erden, ÇOLAK, SEDA, KASIM, İSMAİL, Fatma Erden, İsmail Kasım, Seda Yürümez Çolak, Ahmet Omma, ÖZKARA, ADEM   +15 more
core   +1 more source

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

Advanced Science, EarlyView.
After oral administration, inodorous GLU‐BA self‐assembles into nanomicelles in aqueous environments to resist premature gastric adsorption. Upon reaching the intestine, endogenous esterases rapidly cleave the built‐in ester bonds in these nanomicelles to release BA and GLU, with GLU further metabolized by gut microbiota to gradually generate BA ...
Feifei Xin, Zhike Xie, Danyue Zhao, Lin Yang, Yiqun Wan, Zuwei Liu, Situ Xiong, Ying Zhang, Lei Feng, Hao Wan   +9 more
wiley   +1 more source

Associations Between Dietary Diversity Score and Adiposity Indexes in Obese Adolescents

JCRPE
Objective: Nutrition may affect visceral adipose tissue, but the effect of dietary diversity on visceral adiposity is unknown. Our aim was to investigate the relationship between dietary diversity and visceral adiposity indices and biochemical parameters
Rukiye Bozbulut, Mehmet Ali Oktay, Ulaş Akçay, Esra Döğer, Aylin Kılınç Uğurlu, Mahmut Orhun Çamurdan, Aysun Bideci   +6 more
doaj   +1 more source

Significance of the Visceral Adiposity Index and Other Indicators in Identifying Metabolic Subtypes

Objective: Metabolic phenotypes associated with high cardiovascular risk have been described. The visceral adiposity index (VAI) is a simple indicator of increased visceral adipose tissue using anthropometric and lipid parameters.
Fatma Nur Korkmaz, Demet Çorapçıoğlu, Asena Gökçay Canpolat   +2 more
core   +1 more source