Results 1 to 10 of about 35,819 (203)

Paraventricular Mast Cell-Derived Histamine Activates CRH Neurons to Mediate Adult Visceral Hypersensitivity Induced by Neonatal Maternal Separation [PDF]

Brain Sciences, 2023
Neonatal maternal separation (NMS) is an early-life stress (ELS) that can result in adult visceral hypersensitivity, which is usually manifested as chronic visceral pain.
Ziyang Chen, Tiantian Zhou, Yunfan Li, Tingting Li, Zhengnian Ding, Li Liu   +5 more
doaj   +2 more sources

Global research progress of visceral hypersensitivity and irritable bowel syndrome: bibliometrics and visualized analysis [PDF]

Frontiers in Pharmacology, 2023
Background: Irritable bowel syndrome (IBS) is a group of functional intestinal disorders characterized by abdominal pain, bloating, and changes in bowel habits, and/or stool characteristics.
Siyu Tian, Hang Zhang, Siqi Chen, Pengning Wu, Min Chen   +4 more
doaj   +2 more sources

Role of hippocampal circKcnk9 in visceral hypersensitivity and anxiety comorbidity of irritable bowel syndrome [PDF]

Frontiers in Cellular Neuroscience, 2022
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by recurrent visceral pain and altered bowel habits (diarrhea or constipation). However, the molecular and pathological mechanisms are poorly understood.
Yuan Liu, Zhong Chen, Wei Lin, Yifei Zhou, Zihan Liu, Ruixia Zhao, Yu Chen, Bin Wu, Aiqin Chen, Chun Lin, Chun Lin   +10 more
doaj   +2 more sources

Upregulation of Netrin-1 in the hippocampus mediates the formation of visceral hypersensitivity induced by maternal separation [PDF]

Frontiers in Molecular Neuroscience, 2022
Early adverse life events (EALs), such as maternal separation (MS), can cause visceral hypersensitivity, which is thought to be a key pathophysiological mechanism of irritable bowel syndrome (IBS). Previous studies mainly focused on EALs-induced visceral
Junwen Wang, Guangbing Duan, Tingting Zhan, Zhiyu Dong, Yan Zhang, Ying Chen, Huihui Sun, Shuchang Xu   +7 more
doaj   +2 more sources

Microglia-mediated BLA glutamatergic neuronal hyperactivity in the BLA-ACC pathway contributes to stress-induced visceral hypersensitivity and anxiety in rats [PDF]

Molecular Medicine
Background Visceral hypersensitivity and anxiety are frequently present as comorbidities in patients with irritable bowel syndrome (IBS). We previously found that both the basolateral amygdala (BLA) and the anterior cingulate cortex (ACC) are involved in
Guang-Bing Duan, Jun-Wen Wang, Hui-Hui Sun, Ying Chen, Ewan St John Smith, Ying Huang, Shu-Chang Xu   +6 more
doaj   +2 more sources

Sympathetic Overactivation Drives Colonic Eosinophil Infiltration Linked to Visceral Hypersensitivity in Irritable Bowel SyndromeSummaryWhat You Need to Know [PDF]

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Mucosal immune alteration is a characteristic clinical manifestation of irritable bowel syndrome (IBS), and its symptoms are often triggered by psychological stress.
Shaoqi Duan, Hirosato Kanda, Feng Zhu, Masamichi Okubo, Taro Koike, Yoshiya Ohno, Toshiyuki Tanaka, Yukiko Harima, Kazunari Miyamichi, Hirokazu Fukui, Shinichiro Shinzaki, Yilong Cui, Koichi Noguchi, Yi Dai   +13 more
doaj   +2 more sources

Mechanosensory Piezo2 regulated by gut microbiota participates in the development of visceral hypersensitivity and intestinal dysmotility [PDF]

Gut Microbes
The gut microbiota plays a crucial role in the manifestation of intestinal dysfunction associated with irritable bowel syndrome (IBS). The mechanosensory Piezo2 has been implicated in the regulation of intestinal function.
Haonan Zheng, Yuzhu Chen, Siqi Lu, Zuojing Liu, Yinchao Ma, Cunzheng Zhang, Yiming Zhang, Jindong Zhang, Chang Liu, Ming Chu, Fei Pei, Shuangjiang Liu, Liping Duan   +12 more
doaj   +2 more sources

The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats. [PDF]

, 2013
Corticotropin releasing factor receptor 1 (CRF1) is the key receptor that mediates stress-related body responses. However to date there are no CRF1 antagonists that have shown clinical efficacy in stress-related diseases.
Czimmer, József, Hoffman, Diane C, Kehne, John, Luckey, Andrew, Maynard, George D, Million, Mulugeta, Taché, Yvette, Zhao, Jing-Fang   +7 more
core   +11 more sources

Small-Conductance Ca2+-Activated K+ Channels 2 in the Hypothalamic Paraventricular Nucleus Precipitates Visceral Hypersensitivity Induced by Neonatal Colorectal Distension in Rats

Frontiers in Pharmacology, 2021
Visceral hypersensitivity is one of the pivotal pathophysiological features of visceral pain in irritable bowel syndrome (IBS). Small-conductance Ca2+-activated K+ channel (SK) is critical for a variety of functions in the central nervous system (CNS ...
Ning-Ning Ji, Lei Du, Lei Du, Ying Wang, Ke Wu, Zi-Yang Chen, Rong Hua, Yong-Mei Zhang   +7 more
doaj   +1 more source

Detection and Evaluation Methods of Visceral Sensitivity in Irritable Bowel Syndrome: a Review of the Latest Developments [PDF]

Zhongguo quanke yixue, 2023
Visceral hypersensitivity is one major pathophysiological characteristic of irritable bowel syndrome (IBS) , a common functional bowel disorder. The detection and evaluation of visceral hypersensitivity are of practical significance for the guidance of ...
HOU Yujun, ZHAO Ying, JIANG Huiling, TAN Yu, ZHANG Wei, LI Ying, ZHENG Qianhua
doaj   +1 more source