Results 91 to 100 of about 18,784 (212)

An interorgan neuroimmune circuit promotes visceral hypersensitivity

Abstract Visceral pain disorders such as interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS) often manifest concurrently in the bladder and colon. Yet, the mechanistic basis of such comorbidities and the transmission of neural hypersensitivity across organ systems has remained a mystery.
Brian Kim, Zhen Wang, Xia Meng, Zili Xie, Chia Chun Hor, wenwen zhang, Xu Li, Keaton Song, Kelsey Auyeung, Hisato Iriki, Rintaro Shibuya, Wen Zhang, Jack Major, Lydia Zamidar, Daniel Yassky, Olivia Seker, Joshua Wollam, Christiane Villescaz, Alan Vest, Swetha Sriniva, Michelle Solomon, Rui Chang, Shruti Naik, Masato Kubo, Veena Viswanath, Shawn Xu, Xinzhong Dong, David Artis, Bo Duan, Hongzhen Hu   +29 more
openaire   +2 more sources

“Is This Edible Anyway?” The Impact of Culture on the Evolution (and Devolution) of Mushroom Knowledge

Topics in Cognitive Science, EarlyView.
Abstract Mushrooms are a ubiquitous and essential component in our biological environment and have been of interest to humans around the globe for millennia. Knowledge about mushrooms represents a prime example of cumulative culture, one of the key processes in human evolution.
Andrea Bender, Åge Oterhals
wiley   +1 more source

A primary auditory cortex-anterior cingulate cortex circuit underlying cross-modal visceral pain modulation

Nature Communications
Visceral pain represents an unmet clinical need due to the lack of safe and generalizable therapies. Given the analgesic potential of music and the underlying crosstalk between auditory and nociceptive pathways, this study aims to delineate the neural ...
Yang Yu, Wen-Qiong Kuang, Yu-Hang He, Qian-Qian Chen, Yong-Chang Li, Fu-Chao Zhang, Hua-Dong Ni, Guang-Yin Xu   +7 more
doaj   +1 more source

Women in space: A review of known physiological adaptations and health perspectives

Experimental Physiology, EarlyView.
Abstract Exposure to the spaceflight environment causes adaptations in most human physiological systems, many of which are thought to affect women differently from men. Since only 11.5% of astronauts worldwide have been female, these issues are largely understudied.
Millie Hughes‐Fulford, Danielle J. Carroll, Heather C. M. Allaway, Bonnie J. Dunbar, Aenor J. Sawyer   +4 more
wiley   +1 more source

The long road to diagnosis, from gastroesophageal reflux disease, through Barrett's esophagus, to visceral hypersensitivity: a case report

Journal of Education, Health and Sport
Background: Visceral hypersensitivity syndrome is a condition involving excessive perception of mechanical stimuli in the intestines. In patients suffering from this disorder, physiological bowel function causes pain and discomfort.
Małgorzata Wirkijowska, Jolanta Mędyk, Yauheniya Patarocha, Michał Rogulski, Aleksandra Ślusarska, Paulina Błasiak, Patryk Mikołajec, Ruslan Huk, Barbara Bilecka, Jakub Wirkijowski   +9 more
doaj   +1 more source

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology, EarlyView.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
wiley   +1 more source

TRPA1 in the spinal dorsal horn is involved in post-inflammatory visceral hypersensitivity: in vivo study using TNBS-treated rat model

Journal of Pain Research, 2016
Qian Li,1,* Cheng-Hao Guo,2,* Mohammed Ali Chowdhury,1 Tao-Li Dai,1 Wei Han,1,3 1Department of Gastroenterology, Qilu Hospital of Shandong University, 2Department of Pathology, Medical School of Shandong University, 3Laboratory of Translational ...
Li Q, Guo C, Chowdhury MA, Dai T, Han W
doaj  

Environmental enrichment reverses stress-induced changes in the brain-gut axis to ameliorate chronic visceral and somatic hypersensitivity

Neurobiology of Stress
Introduction: Behavioral therapies, including cognitive behavioral therapy, hypnotherapy and stress management activities, have emerged as effective treatments for irritable bowel syndrome (IBS), a female predominant disorder of the brain-gut axis.
A. Orock, A.C. Johnson, E. Mohammadi, B. Greenwood-Van Meerveld   +3 more
doaj   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu, Alex Liang, Benjamin U. Hoffman, Dawn M. Schiehser, Oliver Case, Alan Simmons, Ruth Klaming, Andres Gottfried‐Blackmore, Ravinder K. Mittal, Christopher Puleo, Hubert Lim, Imanuel Lerman   +11 more
wiley   +1 more source