Results 101 to 110 of about 309,484 (272)

Accounting for Friendlessness: Stigma and the Quest for an Honorable Self

Symbolic Interaction, EarlyView.
How do people who identify as friendless make sense of their condition in a moment when friendship is extolled for the support and satisfaction it offers? This article draws on interviews with 21 adults in an Atlantic Canadian city. We argue that our interviewees were rarely at ease with their friendlessness and were at pains to recover an honorable ...
Laura Eramian, Peter Mallory
wiley   +1 more source

P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors [PDF]

, 2016
Activation of visceral nociceptors by inflammatory mediators contributes to visceral hypersensitivity and abdominal pain associated with many gastrointestinal disorders.
Baker, MD, Blackshaw, LA, Boundouki, G, Bulmer, DC, Cibert-Goton, V, Hockley, JRF, Knowles, CH, McGuire, C, Michael, GJ, Thaha, MA, Tranter, MM, Winchester, WJ   +11 more
core   +1 more source

New insights into visceral hypersensitivity—clinical implications in IBS [PDF]

Nature Reviews Gastroenterology & Hepatology, 2011
A subset of patients with IBS have visceral hypersensitivity and/or somatic hypersensitivity. Visceral hypersensitivity might have use as a clinical marker of IBS and could account for symptoms of urgency for bowel movements, bloating and abdominal pain. The mechanisms that lead to chronic visceral hypersensitivity in patients who have IBS are unclear.
QiQi, Zhou, G Nicholas, Verne
openaire   +2 more sources

Electroacupuncture Inhibits the Activity of Astrocytes in Spinal Cord in Rats with Visceral Hypersensitivity by Inhibiting P2Y1 Receptor-Mediated MAPK/ERK Signaling Pathway

Evidence-Based Complementary and Alternative Medicine, 2020
Background Irritable bowel syndrome (IBS) is a chronic functional bowel disease characterized by abdominal pain and changes in bowel habits in the absence of organic disease.
Jingming Zhao, Hui Li, Chong Shi, Tiezheng Yang, Baoshi Xu   +4 more
semanticscholar   +1 more source

Psilocybin as a novel treatment for chronic pain

British Journal of Pharmacology, EarlyView.
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey, Reena Lasrado, Maria Maiarú, Gary J. Stephens   +3 more
wiley   +1 more source

Visceral pain: gut microbiota, a new hope?

Journal of Biomedical Science, 2018
Background Visceral pain is a complex and heterogeneous disorder, which can range from the mild discomfort of indigestion to the agonizing pain of renal colic. Regulation of visceral pain involves the spinal cord as well as higher order brain structures.
Matteo M Pusceddu, Melanie G Gareau
doaj   +1 more source

Regional brain activation during rectal distention and attenuation with alosetron in a nonhuman primate model of irritable bowel syndrome

FASEB BioAdvances, 2022
Greater understanding of the mechanism that mediates visceral pain and hypersensitivity associated with irritable bowel syndrome (IBS) would facilitate the development of effective therapeutics to manage these symptoms.
Rintaro Fujii, Yuji Awaga, Kenya Nozawa, Mayumi Matsushita, Aldric Hama, Takahiro Natsume, Hiroyuki Takamatsu   +6 more
doaj   +1 more source

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]

, 2017
Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe, Bernabucci, Matteo, Bruno, Valeria Maria Gloria, Cannella, Milena, Gradini, Roberto, Imbriglio, Tiziana, Mascio, Giada, Nicoletti, Ferdinando, Notartomaso, Serena, Scarselli, Pamela, Zappulla, Cristina   +10 more
core   +1 more source

Ephrin‐B2 signaling in the spinal cord as a player in post‐inflammatory and stress‐induced visceral hypersensitivity

Neurogastroenterology and Motility, 2020
Ephrin‐B2/EphB receptor signaling contributes to persistent pain states such as postinflammatory and neuropathic pain. Visceral hypersensitivity (VHS) is a major mechanism underlying abdominal pain in patients with irritable bowel syndrome (IBS) and ...
Stavroula A Theofanous, M. Florens, Iris Appeltans, Alexandre Denadai Souza, J. Wood, M. Wouters, G. Boeckxstaens   +6 more
semanticscholar   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source