Results 21 to 30 of about 18,784 (212)
Zeta Inhibitory Peptide as a Novel Therapy to Control Chronic Visceral Hypersensitivity in a Rat Model. [PDF]
PLoS ONE, 2016 The pathogenesis of multiple chronic visceral pain syndromes, such as irritable bowel syndrome (IBS), is not well known, and as a result current therapies are ineffective. The objective of this study was to investigate the effect of spinal protein kinase
Ying Tang +7 more
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Frontiers in Pharmacology, 2018 Visceral hypersensitivity is a highly complex and subjective phenomenon associated with multiple levels of the nervous system and a wide range of neurotransmission.
Yu Song +9 more
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Central neural mechanisms mediating human visceral hypersensitivity [PDF]
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2001 Although visceral hypersensitivity is thought to be important in generating symptoms in functional gastrointestinal disorders, the neural mechanisms involved are poorly understood. We recently showed that central sensitization (hyperexcitability of spinal cord sensory neurones) may play an important role.
S, Sarkar +5 more
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Frontiers in Endocrinology, 2022 Electroacupuncture (EA) is considered to have a therapeutic effect in the relief of irritable bowel syndrome (IBS)-associated visceral hypersensitivity via the reduction of the level of 5‐hydroxytryptamine (5‐HT) and 5-HT3 receptors (5-HT3R).
Jing Guo +12 more
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Early‐life adversity, epigenetics, and visceral hypersensitivity [PDF]
Neurogastroenterology & Motility, 2017 AbstractAbdominal pain is associated with many gastrointestinal dysfunctions, such as irritable bowel syndrome (IBS), functional dyspepsia, and inflammatory bowel disease (IBD). Visceral hypersensitivity is a key reason for development of abdominal pain that presents in these gastrointestinal disorders/diseases.
S. Liu, SI. Hagiwara, A. Bhargava
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Frontiers in Pharmacology, 2017 Neonatal maternal separation (MS) is a major early life stress that increases the risk of emotional disorders, visceral pain perception and other brain dysfunction.
Hui-Li Tang +7 more
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Gastroenterology Research and Practice, 2018 Background. Visceral hypersensitivity is a common feature of irritable bowel syndrome. Cholinergic system involves in the development of visceral hypersensitivity, and high-affinity choline transporter (CHT1) is of crucial importance in choline uptake ...
Chen Zhao +3 more
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Visceral pain hypersensitivity in functional gastrointestinal disorders [PDF]
British Medical Bulletin, 2009 Functional gastrointestinal disorders (FGIDs) are a highly prevalent group of heterogeneous disorders whose diagnostic criteria are symptom based in the absence of a demonstrable structural or biochemical abnormality. Chronic abdominal pain or discomfort is a defining characteristic of these disorders and a proportion of patients may display heightened
A D, Farmer, Q, Aziz
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Neurotrophin signaling and visceral hypersensitivity [PDF]
Frontiers in Biology, 2014 Neurotrophin family are traditionally recognized for their nerve growth promoting function and are recently identified as crucial factors in regulating neuronal activity in the central and peripheral nervous systems. The family members including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) are reported ...
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Frontiers in Cellular Neuroscience, 2022 Tandospirone, a third-generation of antianxiety agent with fewer side effects, has been widely used in the treatment of anxiety. Moreover, it is interesting that tandospirone has been found to relieve gastrointestinal symptoms in patients with refractory
Ting-Ting Zhan +9 more
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