Results 21 to 30 of about 309,484 (272)
Contemporary management of pain in cirrhosis: Toward precision therapy for pain
Hepatology, EarlyView., 2022 Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman +4 more
wiley +1 more source
Unraveling the role of Epac1-SOCS3 signaling in the development of neonatal-CRD-induced visceral hypersensitivity in rats. [PDF]
CNS Neurosci Ther, 2022 Visceral hypersensitivity in irritable bowel syndrome (IBS) is widespread, but effective therapies for it remain elusive. As a canonical anti‐inflammatory protein, suppressor of cytokine signaling 3 (SOCS3) reportedly relays exchange protein 1 directly ...
Huang ST +5 more
europepmc +2 more sources
Progress on the Mechanism of Visceral Hypersensitivity in Nonerosive Reflux Disease
Gastroenterology Research and Practice, 2022 Nonerosive reflux disease (NERD) is the most common type of gastroesophageal reflux disease (GERD). Its clinical symptoms can recur, and clinical treatment is often ineffective, causing patients severe economic and psychological burden.
Cao Xu, Xiaoping Niu
semanticscholar +1 more source
Gut pain & visceral hypersensitivity [PDF]
British Journal of Pain, 2013 Visceral pain is a highly complex entity whose experience is variable in health and disease. It can occur in patients with organic disease and also in those without any readily identifiable structural or biochemical abnormality such as in the functional gastrointestinal disorders (FGID).
Adam D, Farmer, Qasim, Aziz
openaire +2 more sources
The role of visceral hypersensitivity in the pathogenesis of irritable bowel syndrome
Терапевтический архив, 2021 This research includes visceral sensitivity and its mechanisms involved in the development of irritable bowel syndrome. Visceral hypersensitivity occupies the key place.
Alina A. Makarova +4 more
doaj +1 more source
Evidence-Based Complementary and Alternative Medicine, 2022 Objective To determine whether electroacupuncture (EA) could alleviate visceral hypersensitivity in diarrhea-predominant irritable bowel syndrome (IBS-D) rats by inhibiting EGCs activity via the BDNF/TrkB signaling pathway.
Ying Zhao +9 more
semanticscholar +1 more source
Endocannabinoid-related compounds in gastrointestinal diseases [PDF]
, 2018 The endocannabinoid system (ECS) is an endogenous signalling pathway involved in the control of several gastrointestinal (GI) functions at both peripheral and central levels.
Alessandra, D'Alessandro +7 more
core +3 more sources
Visceral hypersensitivity: facts, speculations, and challenges [PDF]
Gut, 2001 Visceral hypersensitivity is currently the holy grail....it is widely regarded as the reason for the development of functional gastrointestinal diseases, including functional dyspepsia and irritable bowel syndrome.1 Although the field has advanced considerably in the past decade, it is necessary to take stock and realistically appraise our current ...
M, Camilleri, B, Coulie, J F, Tack
openaire +2 more sources
Acupuncture & Herbal Medicine, 2022 Objective: The present study aims to evaluate the in vivo efficacy of YINDARA-4 in improving the symptoms of irritable bowel syndrome (IBS) in a rat model and investigate the impact of YINDARA-4 on potential targets of IBS management, such as the ...
Yaqin Ling +4 more
semanticscholar +1 more source
Adrenergic β2-receptors mediates visceral hypersensitivity induced by heterotypic intermittent stress in rats. [PDF]
PLoS ONE, 2014 Chronic visceral pain in patients with irritable bowel syndrome (IBS) has been difficult to treat effectively partially because its pathophysiology is not fully understood.
Chunhua Zhang +7 more
doaj +1 more source