Results 31 to 40 of about 18,784 (212)

Aluminum Ingestion Promotes Colorectal Hypersensitivity in RodentsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2019
Background & Aims: Irritable bowel syndrome (IBS) is a multifactorial disease arising from a complex interplay between genetic predisposition and environmental influences. To date, environmental triggers are not well known.
Nicolas Esquerre, Lilian Basso, Caroline Dubuquoy, Madjid Djouina, Daniel Chappard, Catherine Blanpied, Pierre Desreumaux, Nathalie Vergnolle, Cécile Vignal, Mathilde Body-Malapel   +9 more
doaj   +1 more source

Visceral hypersensitivity is provoked by 2,4,6-trinitrobenzene sulfonic acid-induced ileitis in rats

Frontiers in Pharmacology, 2016
Background and Aims: Crohn’s Disease (CD), a chronic Inflammatory Bowel Disease, can occur in any part of the gastrointestinal tract, but most frequently in the ileum.
Manoj Kumar Shah, Juan Wan, Habibullah Janyaro, Adnan Hassan Tahir, Luying Cui, Ming-Xing Ding   +5 more
doaj   +1 more source

Imeglimin prevents visceral hypersensitivity and colonic hyperpermeability in irritable bowel syndrome rat model

Journal of Pharmacological Sciences, 2023
Visceral hypersensitivity and leaky gut, which are mediated via corticotropin-releasing factor (CRF) and Toll-like receptor 4 are key pathophysiology of irritable bowel syndrome (IBS). Metformin was reported to improve these gastrointestinal (GI) changes.
Tsukasa Nozu, Saori Miyagishi, Masatomo Ishioh, Kaoru Takakusaki, Toshikatsu Okumura   +4 more
doaj   +1 more source

Neonatal Colonic Inflammation Increases Spinal Transmission and Cystathionine β-Synthetase Expression in Spinal Dorsal Horn of Rats with Visceral Hypersensitivity

Frontiers in Pharmacology, 2017
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by chronic abdominal pain and alteration of bowel movements. The pathogenesis of visceral hypersensitivity in IBS patients remains largely unknown.
Liting Zhao, Ying Xiao, Rui-Xia Weng, Xuelian Liu, Ping-An Zhang, Chuang-Ying Hu, Shan P. Yu, Guang-Yin Xu   +7 more
doaj   +1 more source

Maternal Separation Induced Visceral Hypersensitivity Evaluated via Novel and Small Size Distention Balloon in Post-weaning Mice

Frontiers in Neuroscience, 2022
Early life stress (ELS) disposes to functional gastrointestinal diseases in adult, such as irritable bowel syndrome (IBS). Maternal separation (MS) is a well-known animal model of IBS and has been shown to induce visceral hypersensitivity in adult rats ...
Enfu Tao, Enfu Tao, Gao Long, Ting Yang, Bo Chen, Rui Guo, Diya Ye, Marong Fang, Mizu Jiang   +8 more
doaj   +1 more source

Predisposition of Neonatal Maternal Separation to Visceral Hypersensitivity via Downregulation of Small-Conductance Calcium-Activated Potassium Channel Subtype 2 (SK2) in Mice

Neural Plasticity, 2020
Background. Visceral hypersensitivity is a common occurrence of gastrointestinal diseases such as irritable bowel syndrome (IBS), wherein early-life stress (ELS) may have a high predisposition to the development of visceral hypersensitivity in adulthood,
Ke Wu, Jing-hua Gao, Rong Hua, Xiao-han Peng, Hui Wang, Yong-mei Zhang   +5 more
doaj   +1 more source

Dietary monosodium glutamate increases visceral hypersensitivity in a mouse model of visceral pain

Neurogastroenterology & Motility, 2023
AbstractBackgroundMonosodium glutamate (MSG) has been identified as a trigger of abdominal pain in irritable bowel syndrome (IBS), but the mechanism is unknown. This study examined whether MSG causes visceral hypersensitivity using a water‐avoidance stress (WAS) mouse model of visceral pain.MethodsMice were divided into four groups receiving treatment ...
Bailey J. A. Brant, Yang Yu, Amal Abu Omar, Josue O. Jaramillo Polanco, Cintya D. Lopez Lopez, Nestor N. Jiménez Vargas, Quentin Tsang, Abby McDonell, Kaede Takami, David E. Reed, Alan E. Lomax, Stephen J. Vanner, Caroline J. Tuck   +12 more
openaire   +3 more sources

Sexually Dimorphic Effects of Histamine Degradation by Enteric Glial Histamine N-Methyltransferase (HNMT) on Visceral Hypersensitivity

Biomolecules, 2023
Histamine is a neuromodulator that affects gut motility and visceral sensitivity through intrinsic and extrinsic neural pathways, yet the mechanisms regulating histamine availability in these pathways remain poorly understood.
Jonathon L. McClain, Wilmarie Morales-Soto, Jacques Gonzales, Visha Parmar, Elena Y. Demireva, Brian D. Gulbransen   +5 more
doaj   +1 more source

Specific alteration of rhythm in temperature-stressed rats possess features of abdominal pain in IBS patients

Journal of Pharmacological Sciences, 2015
It is known that specific alteration of rhythm in temperature (SART) stress produces somatic pain. However, it remains to be investigated whether SART stress induces visceral pain.
Yasuo Itomi, Toru Kawamura, Yasuhiro Tsukimi   +2 more
doaj   +1 more source

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

Advanced Science, EarlyView.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen, Meiqi Cheng, Jianhui Wang, Jing Tang, Xiaoqiao Huang, Yusi Li, Huiling Zhou, Ling Zhang, Yi Dong, Chengjun Li, Bin Li   +10 more
wiley   +1 more source