Results 31 to 40 of about 309,484 (272)

Visceral hypersensitivity in irritable bowel syndrome [PDF]

Journal of Gastroenterology and Hepatology, 2011
AbstractAltered central processing, abnormal gastrointestinal motility and visceral hypersensitivity may be possible major pathophysiology of irritable bowel syndrome (IBS). These factors affect each other and are probably associated with development of IBS symptoms.It has been confirmed that lower pain threshold to colonic distention was observed in ...
Motoyori, Kanazawa, Michio, Hongo, Shin, Fukudo   +2 more
openaire   +2 more sources

Methyltransferase-like 3 modulates visceral hypersensitivity through regulating the nuclear export of circKcnk9 in YTHDC1-dependent manner

Molecular Pain, 2022
Background: Accumulating evidence shows that N6-methyladenosine (m6A) modulators contribute to the process of chronic pain. However, the exact mechanisms of m6A writers involved in visceral hypersensitivity of Irritable bowel syndrome (IBS) remain ...
Wei Lin, Yuan Liu, Yifei Zhou, Mengying Lin, Congxu Liu, Ying Tang, Bin Wu, Chun Lin   +7 more
semanticscholar   +1 more source

NaV1.1 inhibition can reduce visceral hypersensitivity [PDF]

JCI Insight, 2018
Functional bowel disorder patients can suffer from chronic abdominal pain, likely due to visceral hypersensitivity to mechanical stimuli. As there is only a limited understanding of the basis of chronic visceral hypersensitivity (CVH), drug-based management strategies are ill defined, vary considerably, and include NSAIDs, opioids, and even ...
Juan Salvatierra, Joel Castro, Andelain Erickson, Qian Li, Joao Braz, John Gilchrist, Luke Grundy, Grigori Y. Rychkov, Annemie Deiteren, Rana Rais, Glenn F. King, Barbara S. Slusher, Allan Basbaum, Pankaj J. Pasricha, Stuart M. Brierley, Frank Bosmans   +15 more
openaire   +5 more sources

Olorinab (APD371), a peripherally acting, highly selective, full agonist of the cannabinoid receptor 2, reduces colitis-induced acute and chronic visceral hypersensitivity in rodents

Pain, 2021
Olorinab—a highly selective, full agonist of the cannabinoid receptor 2—significantly reduces visceral hypersensitivity and colonic nociceptor firing in inflammatory bowel disease–like and irritable bowel syndrome–like rodent models.
J. Castro, S. Garcia-Caraballo, Jessica Maddern, G. Schober, A. Lumsden, A. Harrington, Shirdi E Schmiel, B. Lindstrom, John Adams, S. Brierley   +9 more
semanticscholar   +1 more source

Zeta Inhibitory Peptide as a Novel Therapy to Control Chronic Visceral Hypersensitivity in a Rat Model. [PDF]

PLoS ONE, 2016
The pathogenesis of multiple chronic visceral pain syndromes, such as irritable bowel syndrome (IBS), is not well known, and as a result current therapies are ineffective. The objective of this study was to investigate the effect of spinal protein kinase
Ying Tang, Aiqin Chen, Yu Chen, Lixia Guo, Hengfen Dai, Yang Huang, Qianqian Chen, Chun Lin   +7 more
doaj   +1 more source

Circadian dysregulation induces alterations of visceral sensitivity and the gut microbiota in Light/Dark phase shift mice

Frontiers in Microbiology, 2022
BackgroundIt is well-established that several features of modern lifestyles, such as shift work, jet lag, and using electronics at night, disturb normal circadian rhythm and increase the risk of suffering from functional gastrointestinal disease ...
Lilin Hu, Gangping Li, Yanyun Shu, Xiaohua Hou, Ling Yang, Yu Jin   +5 more
doaj   +1 more source

Small-Conductance Ca2+-Activated K+ Channel 2 in the Dorsal Horn of Spinal Cord Participates in Visceral Hypersensitivity in Rats

Frontiers in Pharmacology, 2018
Visceral hypersensitivity is a highly complex and subjective phenomenon associated with multiple levels of the nervous system and a wide range of neurotransmission.
Yu Song, Jun-Sheng Zhu, Rong Hua, Rong Hua, Lei Du, Si-Ting Huang, Robert W. Stackman, Gongliang Zhang, Gongliang Zhang, Yong-Mei Zhang   +9 more
doaj   +1 more source

Central neural mechanisms mediating human visceral hypersensitivity [PDF]

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2001
Although visceral hypersensitivity is thought to be important in generating symptoms in functional gastrointestinal disorders, the neural mechanisms involved are poorly understood. We recently showed that central sensitization (hyperexcitability of spinal cord sensory neurones) may play an important role.
S, Sarkar, A R, Hobson, P L, Furlong, C J, Woolf, D G, Thompson, Q, Aziz   +5 more
openaire   +2 more sources

Local Colonic Administration of a Serine Protease Inhibitor Improves Post-Inflammatory Visceral Hypersensitivity in Rats

Pharmaceutics, 2021
Dysregulation of the protease–antiprotease balance in the gastrointestinal tract has been suggested as a mechanism underlying visceral hypersensitivity in conditions such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). We aimed to
Nikita Hanning, M. De Bruyn, H. Ceuleers, Tim Boogaerts, M. Berg, A. Smet, H. D. De Schepper, Jurgen Joossens, A. V. van Nuijs, J. D. De Man, K. Augustyns, I. De Meester, B. D. De Winter   +12 more
semanticscholar   +1 more source

Toll-Like Receptor 4 in Paraventricular Nucleus Mediates Visceral Hypersensitivity Induced by Maternal Separation

Frontiers in Pharmacology, 2017
Neonatal maternal separation (MS) is a major early life stress that increases the risk of emotional disorders, visceral pain perception and other brain dysfunction.
Hui-Li Tang, Hui-Li Tang, Gongliang Zhang, Ning-Ning Ji, Lei Du, Bin-Bin Chen, Rong Hua, Yong-Mei Zhang   +7 more
doaj   +1 more source