Results 41 to 50 of about 309,484 (272)

Electroacupuncture Attenuates Post-Inflammatory IBS-Associated Visceral and Somatic Hypersensitivity and Correlates With the Regulatory Mechanism of Epac1–Piezo2 Axis

Frontiers in Endocrinology, 2022
Electroacupuncture (EA) is considered to have a therapeutic effect in the relief of irritable bowel syndrome (IBS)-associated visceral hypersensitivity via the reduction of the level of 5‐hydroxytryptamine (5‐HT) and 5-HT3 receptors (5-HT3R).
Jing Guo, Jing Guo, Lu Chen, Yu-hang Wang, Ya-fang Song, Zhan-hao Zhao, Ting-ting Zhao, Zhi-ying Lin, Dong-mei Gu, Yun-qi Liu, Yong-jun Peng, Li-xia Pei, Jian-hua Sun   +12 more
doaj   +1 more source

Early‐life adversity, epigenetics, and visceral hypersensitivity [PDF]

Neurogastroenterology & Motility, 2017
AbstractAbdominal pain is associated with many gastrointestinal dysfunctions, such as irritable bowel syndrome (IBS), functional dyspepsia, and inflammatory bowel disease (IBD). Visceral hypersensitivity is a key reason for development of abdominal pain that presents in these gastrointestinal disorders/diseases.
S. Liu, SI. Hagiwara, A. Bhargava
openaire   +4 more sources

Functional disruption of cortical cingulate activity attenuates visceral hypersensitivity and anxiety induced by acute experimental colitis

Scientific Reports, 2021
Visceral pain is a highly complex experience and is the most common pathological feature in patients suffering from inflammatory gastrointestinal disorders.
Lukas Brenner, Leah Zerlin, L. L. Tan
semanticscholar   +1 more source

NHE3 inhibitor tenapanor maintains intestinal barrier function, decreases visceral hypersensitivity, and attenuates TRPV1 signaling in colonic sensory neurons.

Am J Physiol Gastrointest Liver Physiol
The pathogenesis of irritable bowel syndrome (IBS) is multifactorial, characterized in part by increased intestinal permeability and visceral hypersensitivity. Increased permeability is associated with IBS severity and abdominal pain.
King AJ, Chang L, Li Q, Liu L, Zhu Y, Pasricha PJ, Wang J, Siegel M, Caldwell JS, Edelstein S, Rosenbaum DP, Kozuka K.   +11 more
europepmc   +2 more sources

Purinergic mechanosensory transduction and visceral pain [PDF]

, 2009
In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain.
Burnstock, G
core   +3 more sources

Blockade of BK channels attenuates chronic visceral hypersensitivity in an IBS-like rat model

Molecular Pain, 2021
Background Visceral hypersensitivity in irritable bowel syndrome (IBS) is still poorly understood, despite that chronic abdominal pain is the most common symptoms in IBS patients.
F. Fan, Y. Chen, Z. Chen, L. Guan, Z. Ye, Y. Tang, A. Chen, C. Lin   +7 more
semanticscholar   +1 more source

Blockage of High-Affinity Choline Transporter Increases Visceral Hypersensitivity in Rats with Chronic Stress

Gastroenterology Research and Practice, 2018
Background. Visceral hypersensitivity is a common feature of irritable bowel syndrome. Cholinergic system involves in the development of visceral hypersensitivity, and high-affinity choline transporter (CHT1) is of crucial importance in choline uptake ...
Chen Zhao, Mengjuan Lin, Yasi Pan, Baoping Yu   +3 more
doaj   +1 more source

Immersive Composition for Sensory Rehabilitation: 3D Visualisation, Surround Sound, and Synthesised Music to Provoke Catharsis and Healing [PDF]

, 2014
There is a wide range of sensory therapies using sound, music and visual stimuli. Some focus on soothing or distracting stimuli such as natural sounds or classical music as analgesic, while other approaches emphasize the active performance of producing ...
A. Cohen, A. Gabrielsson, A. Jönsson, A. Ross, A.L. Gerlach, D. Austin, E. Altenmuller, M.J. Roy, S. Goodman, T. Oohashi   +9 more
core   +1 more source

Visceral pain hypersensitivity in functional gastrointestinal disorders [PDF]

British Medical Bulletin, 2009
Functional gastrointestinal disorders (FGIDs) are a highly prevalent group of heterogeneous disorders whose diagnostic criteria are symptom based in the absence of a demonstrable structural or biochemical abnormality. Chronic abdominal pain or discomfort is a defining characteristic of these disorders and a proportion of patients may display heightened
A D, Farmer, Q, Aziz
openaire   +2 more sources

Electroacupuncture at ST36 Relieves Visceral Hypersensitivity via the NGF/TrkA/TRPV1 Peripheral Afferent Pathway in a Rodent Model of Post-Inflammation Rectal Hypersensitivity

Journal of Inflammation Research, 2021
Purpose The aim of the study was to investigate the effects of electroacupuncture (EA) at ST36 on rectal hypersensitivity and compliance in DSS-treated post-inflammation rats.
Yan Chen, Jiafei Cheng, Yiling Zhang, Jiande D. Z. Chen, Florin M Seralu   +4 more
semanticscholar   +1 more source