Results 61 to 70 of about 309,484 (272)

Visceral hypersensitivity is provoked by 2,4,6-trinitrobenzene sulfonic acid-induced ileitis in rats

Frontiers in Pharmacology, 2016
Background and Aims: Crohn’s Disease (CD), a chronic Inflammatory Bowel Disease, can occur in any part of the gastrointestinal tract, but most frequently in the ileum.
Manoj Kumar Shah, Juan Wan, Habibullah Janyaro, Adnan Hassan Tahir, Luying Cui, Ming-Xing Ding   +5 more
doaj   +1 more source

Enhanced c-Fos expression in the central amygdala correlates with increased thigmotaxis in rats with peripheral nerve injury [PDF]

, 2015
Pain is associated with affective, cognitive and sensory dysfunction. Animal models can be used to observe ethologically relevant behaviours such as thigmotaxis, giving insight into how ongoing sensory abnormalities influence natural rodent behaviours ...
Rice, ASC
core   +1 more source

Chronic Early-life Stress in Rat Pups Alters Basal Corticosterone, Intestinal Permeability, and Fecal Microbiota at Weaning: Influence of Sex. [PDF]

, 2017
Background/aimsWistar rat dams exposed to limited nesting stress (LNS) from post-natal days (PND) 2 to 10 display erratic maternal behavior, and their pups show delayed maturation of the hypothalamic-pituitary-adrenal axis and impaired epithelial barrier
Biraud, Mandy, Jacobs, Jonathan P, Larauche, Muriel, Mayer, Emeran, Million, Mulugeta, Moussaoui, Nabila, Taché, Yvette   +6 more
core   +1 more source

Neonatal Colonic Inflammation Increases Spinal Transmission and Cystathionine β-Synthetase Expression in Spinal Dorsal Horn of Rats with Visceral Hypersensitivity

Frontiers in Pharmacology, 2017
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by chronic abdominal pain and alteration of bowel movements. The pathogenesis of visceral hypersensitivity in IBS patients remains largely unknown.
Liting Zhao, Ying Xiao, Rui-Xia Weng, Xuelian Liu, Ping-An Zhang, Chuang-Ying Hu, Shan P. Yu, Guang-Yin Xu   +7 more
doaj   +1 more source

Effect of resolvins on sensitisation of TRPV1 and visceral hypersensitivity in IBS

Gut, 2020
Objective Resolvins (RvD1, RvD2 and RvE1) are endogenous anti-inflammatory lipid mediators that display potent analgesic properties in somatic pain by modulating transient receptor potential vanilloid 1 (TRPV1) activation.
E. Perna, J. Aguilera-Lizarraga, M. Florens, P. Jain, Stavroula A Theofanous, Nikita Hanning, J. D. De Man, M. Berg, Benedicte Y. De Winter, Y. A. Alpizar, K. Talavera, P. Vanden Berghe, M. Wouters, G. Boeckxstaens   +13 more
semanticscholar   +1 more source

Sexually Dimorphic Effects of Histamine Degradation by Enteric Glial Histamine N-Methyltransferase (HNMT) on Visceral Hypersensitivity

Biomolecules, 2023
Histamine is a neuromodulator that affects gut motility and visceral sensitivity through intrinsic and extrinsic neural pathways, yet the mechanisms regulating histamine availability in these pathways remain poorly understood.
Jonathon L. McClain, Wilmarie Morales-Soto, Jacques Gonzales, Visha Parmar, Elena Y. Demireva, Brian D. Gulbransen   +5 more
doaj   +1 more source

Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial [PDF]

, 2004
Background: Patients with irritable bowel syndrome (IBS) often feel they have some form of dietary intolerance and frequently try exclusion diets. Tests attempting to predict food sensitivity in IBS have been disappointing but none has utilised IgG ...
Atkinson, W., Shaath, N., Sheldon, T.A., Whorwell, P.J.   +3 more
core   +3 more sources

Dietary monosodium glutamate increases visceral hypersensitivity in a mouse model of visceral pain

Neurogastroenterology & Motility, 2023
AbstractBackgroundMonosodium glutamate (MSG) has been identified as a trigger of abdominal pain in irritable bowel syndrome (IBS), but the mechanism is unknown. This study examined whether MSG causes visceral hypersensitivity using a water‐avoidance stress (WAS) mouse model of visceral pain.MethodsMice were divided into four groups receiving treatment ...
Bailey J. A. Brant, Yang Yu, Amal Abu Omar, Josue O. Jaramillo Polanco, Cintya D. Lopez Lopez, Nestor N. Jiménez Vargas, Quentin Tsang, Abby McDonell, Kaede Takami, David E. Reed, Alan E. Lomax, Stephen J. Vanner, Caroline J. Tuck   +12 more
openaire   +3 more sources

Prostaglandin E2, Produced by Mast Cells in Colon Tissues from Patients with Irritable Bowel Syndrome, Contributes to Visceral Hypersensitivity in Mice.

Gastroenterology, 2020
BACKGROUND & AIMS Visceral hypersensitivity is common in patients with irritable bowel syndrome (IBS). We investigated whether inflammatory molecules, such as histamine and proteases, activate prostaglandin-endoperoxide synthase 2 (PTGS2, also called ...
G. Grabauskas, Xiaoyin Wu, Jun Gao, Ji-yao Li, D. Turgeon, C. Owyang   +5 more
semanticscholar   +1 more source

Specific alteration of rhythm in temperature-stressed rats possess features of abdominal pain in IBS patients

Journal of Pharmacological Sciences, 2015
It is known that specific alteration of rhythm in temperature (SART) stress produces somatic pain. However, it remains to be investigated whether SART stress induces visceral pain.
Yasuo Itomi, Toru Kawamura, Yasuhiro Tsukimi   +2 more
doaj   +1 more source