Results 61 to 70 of about 18,784 (212)
Visceral hypersensitivity in endometriosis: a new target for treatment? [PDF]
Gut, 2011 In women presenting to gynaecological clinics with lower abdominal pain, the cause is frequently attributed to endometriosis irrespective of whether it is found to be minimal or extensive at laparoscopy. Irritable bowel syndrome (IBS) is also common in this setting, and it was speculated that the visceral hypersensitivity associated with this condition
Issa, B. +6 more
openaire +3 more sources
Neurourology and Urodynamics, EarlyView.ABSTRACT Aims While many patients with lower urinary tract symptoms (LUTS) improve by treating peripheral causes, a substantial proportion continue to experience symptoms despite apparently successful interventions. Central nervous system (CNS) mechanisms could potentially contribute to persisting symptoms after the initial peripheral cause has been ...
Mathijs M. de Rijk +7 more
wiley +1 more source
Pediatric Discovery, EarlyView.Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu +4 more
wiley +1 more source
Advances in the role of intestinal ion channels in the pathogenesis of irritable bowel syndrome [PDF]
Jichu yixue yu linchuang, 2020 Ion channels are widely present in mucous membranes of the digestive tract, their abnormal expression and(or) function are important pathogenic mechanisms of irritable bowel syndrome (IBS).
LAN Fei, LIU Tai-yang, YANG Jie
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The Prostate, EarlyView.ABSTRACT Background Methyl Methanesulfonate‐Sensitivity Protein 22‐Like (MMS22L) plays a key role in homology‐directed DNA repair, and experimental models have shown that its loss confers sensitivity to Poly (ADP‐ribose) polymerase inhibitors (PARPi).
Mayuko Kanayama +12 more
wiley +1 more source
Accounting for Friendlessness: Stigma and the Quest for an Honorable Self
Symbolic Interaction, EarlyView.How do people who identify as friendless make sense of their condition in a moment when friendship is extolled for the support and satisfaction it offers? This article draws on interviews with 21 adults in an Atlantic Canadian city. We argue that our interviewees were rarely at ease with their friendlessness and were at pains to recover an honorable ...
Laura Eramian, Peter Mallory
wiley +1 more source
From Cellular Basis to Clinical Insight: Redefining Peptide YY in Female Visceral Hypersensitivity
Gut Medicine, EarlyView.
Yu Wang, Jin Song
wiley +1 more source
Green Stool Predominance in Babies and Subsequent Bowel Function at 1–2 Years of Age
Acta Paediatrica, EarlyView.ABSTRACT Aim To study the relationship between bowel function after birth and at 1–2 years of age in the prospective HELMi cohort of term infants. Methods We focused on infants with predominantly green stools (n = 152) for three consecutive weeks in early life and their sex, age, and delivery mode‐matched controls (n = 300), and evaluated bowel ...
L. Typpö +5 more
wiley +1 more source
Emotional and Behavioural Problems in Children With Functional Gastrointestinal Disorders
Acta Paediatrica, EarlyView.ABSTRACT Aim Functional gastrointestinal disorders (FGIDs) are common in childhood, but psychological correlates remain poorly understood. We compared emotional and behavioural functioning in children with FGIDs with somatic and healthy controls. Methods Parents of children aged 2–12 years were recruited at the University Children's Hospital Basel ...
Sebastian Weber +4 more
wiley +1 more source
Psilocybin as a novel treatment for chronic pain
British Journal of Pharmacology, EarlyView.Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey +3 more
wiley +1 more source