Results 71 to 80 of about 309,484 (272)

Transcript expression of vesicular glutamate transporters in lumbar dorsal root ganglia and the spinal cord of mice – Effects of peripheral axotomy or hindpaw inflammation [PDF]

, 2013
Using specific riboprobes, we characterized the expression of vesicular glutamate transporter (VGLUT)1–VGLUT3 transcripts in lumbar 4–5 (L4–5) dorsal root ganglions (DRGs) and the thoracolumbar to lumbosacral spinal cord in male BALB/c mice after a 1- or
Brumovsky, Pablo Rodolfo, Gebhart, G. F., Hökfelt, T., Lundgren, K. H., Malet, Mariana, Seal, R. P., Seroogy, K. B., Tomasella, María Eugenia, Vieytes, C. A.   +8 more
core   +1 more source

Metabolomics: The Key to Unraveling the Role of the Microbiome in Visceral Pain Neurotransmission

Frontiers in Neuroscience, 2022
Inflammatory bowel disease (IBD), comprising Crohn’s disease and Ulcerative colitis, is a relapsing and remitting disease of the gastrointestinal tract, presenting with chronic inflammation, ulceration, gastrointestinal bleeding, and abdominal pain.
Adam Shute, Dominique G. Bihan, Ian A. Lewis, Yasmin Nasser   +3 more
doaj   +1 more source

Роль висцеральной гиперчувствительности в развитии синдрома раздраженного кишечника [PDF]

, 2018
У статті розглядаються питання патогенеза синдрому подразненого кишечника. Детально розглянуто один з ключових патогенетичних факторів — вісцеральну гіперчутливість.
Будзак, И.Я., Степанов, Ю.М.   +1 more
core  

Model‐informed precision dosing of carboplatin in cancer patients by leveraging myelosuppression data from electronic health records

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This study aimed to develop and validate a population pharmacokinetic‐pharmacodynamic (pop‐PK‐PD) model to describe carboplatin‐induced myelosuppression in cancer patients and support dose individualization. Methods Data from 580 cancer patients treated with carboplatin at Amsterdam UMC between 2019 and 2022 were used for model ...
Alessandro De Carlo, Elena Maria Tosca, Mirjam Crul, Tim Schutte, Lia van Zuijlen, Idris Bahce, Medhat M. Said, Jan Buter, Harmen Huls, Paolo Magni, Imke Bartelink   +10 more
wiley   +1 more source

Tetrodotoxin: A New Strategy to Treat Visceral Pain?

Toxins, 2021
Visceral pain is one of the most common symptoms associated with functional gastrointestinal (GI) disorders. Although the origin of these symptoms has not been clearly defined, the implication of both the central and peripheral nervous systems in ...
Ana Campos-Ríos, Lola Rueda-Ruzafa, Salvador Herrera-Pérez, Paula Rivas-Ramírez, José Antonio Lamas   +4 more
doaj   +1 more source

Late cutaneous schistosomiasis representing an isolated skin manifestation of Schistosoma mansoni infection [PDF]

, 2000
Ectopic late cutaneous schistosomiasis is usually preceded or accompanied by visceral schistosomiasis infection. Our patient presented the very rare case of late cutaneous schistosomiasis as an isolated skin manifestation.
Kick, G., Korting, Hans Christian, Schaller, M.   +2 more
core   +1 more source

Fusobacterium nucleatum Causes Microbial Dysbiosis and Exacerbates Visceral Hypersensitivity in a Colonization-Independent Manner

Frontiers in Microbiology, 2020
Background: Microbial dysbiosis is closely associated with visceral hypersensitivity and is involved in the pathogenesis of irritable bowel syndrome (IBS), but the specific strains that play a key role have yet to be identified.
Xiang Gu, Li-jin Song, Li-xiang Li, Tong Liu, Ming-ming Zhang, Zhen Li, Peng Wang, Ming Li, X. Zuo   +8 more
semanticscholar   +1 more source

Stress-induced visceral pain in female rats is associated with epigenetic remodeling in the central nucleus of the amygdala

Neurobiology of Stress, 2021
Stress and anxiety contribute to the pathophysiology of irritable bowel syndrome (IBS), a female-predominant disorder of the gut-brain axis, characterized by abdominal pain due to heightened visceral sensitivity.
Tijs Louwies, Albert Orock, Beverley Greenwood-Van Meerveld   +2 more
doaj   +1 more source

Role of brain imaging in disorders of brain-gut interaction: a Rome Working Team Report. [PDF]

, 2019
Imaging of the living human brain is a powerful tool to probe the interactions between brain, gut and microbiome in health and in disorders of brain-gut interactions, in particular IBS.
Aziz, Qasim, Borsook, David, Elsenbruch, Sigrid, Kilpatrick, Lisa, Labus, Jennifer, Mayer, Emeran A, Schweinhardt, Petra, Tracey, Irene, Van Oudenhove, Lukas   +8 more
core   +2 more sources

Construction of a clickable probe‐based protein chip platform for discovering covalent mIDH1 inhibitors from natural medicinal extracts

iMeta, EarlyView.
In this study, we develop a flexible Ccc‐Chip (protein microarray + bioorthogonal click chemistry) for high‐throughput screening of natural covalent active molecules from medicinal plant extracts, identifying flavokawain C from Piper methysticum Forst as a novel covalent mIDH1 inhibitor.
Zhao Cui, Jiameng Li, Caifeng Li, Mo Sun, Wei Liu, Xuxia Cao, Shiwen Deng, Junxian Cao, Hongjun Yang, Peng Chen   +9 more
wiley   +1 more source