Results 71 to 80 of about 18,784 (212)

Effect of the 5-HT4 receptor and serotonin transporter on visceral hypersensitivity in rats

Brazilian Journal of Medical and Biological Research, 2012
Visceral hypersensitivity plays an important role in motor and sensory abnormalities associated with irritable bowel syndrome, but the underlying mechanisms are not fully understood.
Chi Yan, Liu Xin-Guang, Wang Hua-Hong, Li Jun-Xia, Li Yi-Xuan   +4 more
doaj   +2 more sources

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Paediatric Acute Generalised and Localised Exanthematous Pustulosis: A Systematic Review

JEADV Clinical Practice, EarlyView.
Miranda K. Branyiczky, Megan Lowe, Eric McMullen, Shireen Dumont, Narachai Julanon, Vincent Piguet, Cathryn Sibbald   +6 more
wiley   +1 more source

Epicutaneous and Drug Provocation Testing in Severe Cutaneous Adverse Reactions: A 20‐Year Single‐Centre Experience

Contact Dermatitis, EarlyView.
This study provides reassuring evidence in favour of early skin testing in patients with SCARs, argues against the necessity of a 6‐month delay, and underscores the pivotal role of oral provocation tests in the safe reintroduction of essential therapies. ABSTRACT Background Identifying and discontinuing the offending drug(s) in severe cutaneous adverse
Zohra Chadli, Khadija Mansour, Ghada Jaouahdou, Manel Ben Belgacem, Yosra Soua, Nadia Ben Fredj, Jameleddine Zili, Haifa Ben Romdhane, Karim Aouam   +8 more
wiley   +1 more source

P2X3 receptors mediate visceral hypersensitivity during acute chemically-induced colitis and in the post-inflammatory phase via different mechanisms of sensitization.

PLoS ONE, 2015
ObjectivesExperiments using P2X3 knock-out mice or more general P2X receptor antagonists suggest that P2X3 receptors contribute to visceral hypersensitivity.
Annemie Deiteren, Laura van der Linden, Anouk de Wit, Hannah Ceuleers, Roeland Buckinx, Jean-Pierre Timmermans, Tom G Moreels, Paul A Pelckmans, Joris G De Man, Benedicte Y De Winter   +9 more
doaj   +1 more source

Temporary transfer tattoos and their use in student teaching in dermatology ‐ a monocentric observational study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background The teaching of elementary skin lesions and the ABCDE rule are central components of undergraduate medical education in dermatology. This content is typically taught using photographs, moulages, or patient examples. Independent practice under supervision, however, is often difficult to implement in everyday clinical work ...
Conrad Hempel, Franziska Jochims, Jan‐Christoph Simon, Daisy Rotzoll   +3 more
wiley   +1 more source

Attenuation of Visceral and Somatic Nociception by Ghrelin Mimetics

Journal of Experimental Pharmacology, 2020
Ehsan N Mohammadi,1 Tijs Louwies,1 Claudio Pietra,2 S Robert Northrup,3 Beverley Greenwood-Van Meerveld1 1Oklahoma Center for Neuroscience, Department of Physiology, University of Oklahoma Health Science Center, Oklahoma City, OK, USA; 2Helsinn ...
N Mohammadi E, Louwies T, Pietra C, Northrup SR, Greenwood-Van Meerveld B   +4 more
doaj  

The HaMYB22–HaGST3.2 module mediates salt stress response in sunflower

Journal of Integrative Plant Biology, EarlyView.
The transcription factors HaMYB22, HaMYB120, and HaMYB121 cooperatively activate the transcription of the glutathione S‐transferase gene HaGST3.2, thereby facilitating the removal of reactive oxygen species induced by salt stress in sunflowers and improving their salt tolerance.
Siqi Zhang, Yuliang Han, Qixiu Huang, Weijun Guo, Shurui Dong, Xinxin Li, Qian Zhang, Juncheng Zhang, Yijun Meng, Zhonghua Lei, Maohong Cai, Tao Chen   +11 more
wiley   +1 more source

Effects of TAK-480, a Novel Tachykinin NK2–Receptor Antagonist, on Visceral Hypersensitivity in Rabbits and Ricinoleic Acid–Induced Defecation in Guinea Pigs

Journal of Pharmacological Sciences, 2012
TAK-480, 4-(difluoromethoxy)-N-((1R,2S)-2-(((3aR,4R,9bR)-4-(methoxymethyl)-2, 3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinolin-1-yl)carbonyl)cyclohexyl)benzamide, is a novel tachykinin NK2–receptor antagonist.
Takahiro Tanaka, Akiko Tanaka, Akihiro Nakamura, Kozo Matsushita, Akio Imanishi, Shiho Matsumoto-Okano, Nobuhiro Inatomi, Kasei Miura, Masao Toyoda, Gaku Mizojiri, Yasuhiro Tsukimi   +10 more
doaj   +1 more source

Psychological and Clinical Factors Mediate Post‐COVID‐19 Irritable Bowel Syndrome

Neurogastroenterology &Motility, EarlyView.
ABSTRACT Background Exposure to COVID‐19 has been shown previously to be associated with a higher risk for irritable bowel syndrome (IBS). This study aimed to better explain this relationship using mediation analysis. Methods This post hoc analysis of a multicenter cohort study includes 623 patients with and without COVID‐19 infection. All participants
Keren Hod, Giovanni Marasco, Luigi Colecchia, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, M. Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yağcı, Husnu Pullukcu, Berrin Yalınbas Kaya, Ali Tureyen, İbrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Calıskan, Goksel Bengi, Esra Ergun Alıs, Snezana Lukic, Meri Trajkovska, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjolund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara, on behalf of GI‐COVID19 study group   +68 more
wiley   +1 more source