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Vitamin B12

2017
Vitamin B12 is the generic descriptor for all corrinoids (compounds containing the cobalt-centered corrin nucleus) exhibiting the biological activity of cyanocobalamin. Vitamin B12 is not found in fruits or vegetables; meat and fish are the best sources.
Gerald F. Combs, Jr., James P. McClung
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Photolysis of Vitamin B12

Journal of the American Pharmaceutical Association (Scientific ed.), 1956
Abstract The rate of destruction of crystalline vitamin Bu in neutral aqueous solutions, when exposed to direct sunlight, indirect sunlight, dim daylight, artificial light, ultraviolet light, and various monochromatic light sources has been determined.
Catherine Wilson, Leon J. Demerre
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Vitamin B12 and the B12 Coenzymes

1995
Publisher Summary Scientific investigations of the biochemistry of the structure and the mode of action of vitamin B12 have cleared up many of the puzzles regarding its medical relevance to pernicious anemia. Structural studies have revealed a complicated molecule with many sterically constrained areas, honed for efficient use by an enzyme that needs
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Chemistry of Vitamin B12

1957
Publisher Summary Since the chemistry of the antipernicious anemia factor, vitamin B 12 , was last reviewed in “Vitamins and Hormones” by Folkers and Wolf, outstanding progress has been made, resulting in the complete structural elucidation of the vitamin.
Todd A, Johnson Aw
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Chemistry of Vitamin B12

1954
Publisher Summary Soon after the epoch-making recognition of the effectiveness of whole liver therapy for the control of pernicious anemia, various groups of investigators carried out programs on the fractionation of liver extracts for the purification of the active principle.
Donald E. Wolf, Karl Folkers
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Vitamin B12 deficiency

2022
Of the water-soluble vitamins, vitamin B12 (B12) has the lowest daily requirement. It also has several unique properties including a complex pathway for its absorption and assimilation requiring intact gastric and terminal small intestinal function, an enterohepatic pathway, and several dedicated binding proteins and chaperons.
Ralph, Green, Joshua W, Miller
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Vitamin B12 Transporters

2005
The uptake of vitamin B12 from the intestine into the circulation is perhaps the most complex uptake mechanism of all the vitamins, involving no less than five separate VB12-binding molecules, receptors and transporters. Each molecule involved in uptake has a separate affinity and specificity for VB12 as well as a separate cell receptor.
Gregory J. Russell-Jones   +1 more
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Bioavailability of Vitamin B12

International Journal for Vitamin and Nutrition Research, 2010
Vitamin B12 deficiency is common in people of all ages who consume a low intake of animal-source foods, including populations in developing countries. It is also prevalent among the elderly, even in wealthier countries, due to their malabsorption of B12 from food.
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Structure of Vitamin B12 [PDF]

open access: possibleNature, 1956
Jennifer Kamper   +5 more
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Vitamin B12

1975
Vitamin B12 is the term applied to a group of chemically related metabolically equiactive compounds with a central ‘corrin’ ring system (porphyrin-like) surrounding a cobalt atom. The structure of the principle compounds with mammalian activity is shown in Figure 33. In natural form, vitamin B12 is probably bound to protein.
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