Results 61 to 70 of about 687,861 (355)

Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation

Advanced Science, EarlyView.
This article comprehensively explores the pivotal role of mitochondrial function in CD8⁺ T cell immunotherapy. It highlights how mitochondrial dynamics regulate T cell activation, differentiation, and persistence, and how mitochondrial dysfunction leads to immune exhaustion and impaired antitumor/antiviral responses.
Xu Chen, Pei Lin, Ye Lu, Jiarong Zheng, Yunfan Lin, Zihao Zhou, Li Cui, Xinyuan Zhao   +7 more
wiley   +1 more source

Vitamin B12 in Relation to Oxidative Stress: A Systematic Review

Nutrients, 2019
The triage theory posits that modest micronutrient deficiencies may induce reallocation of nutrients to processes necessary for immediate survival at the expense of long-term health.
Erik E van de Lagemaat, L. D. de Groot, E. G. van den Heuvel   +2 more
semanticscholar   +1 more source

A Human Engineered Heart Tissue‐Derived Lipotoxic Diabetic Cardiomyopathy Model Revealed Early Benefits of Empagliflozin

Advanced Science, EarlyView.
This study develops a human engineered heart tissue‐derived model of diabetic cardiomyopathy that accurately replicates the dynamic changes in the structural, contractile, and electrophysiological properties of the myocardium. Furthermore, this model is used to confirm the direct protective effects of empagliflozin on the heart through an SGLT2 off ...
Lin Cai, Yuxin Zhao, Zilong Li, Liping Xiao, Yifan Wu, Shiya Wang, Qian Liu, Yida Ye, Yuxuan Guo, Donghui Zhang   +9 more
wiley   +1 more source

Biohybrid Computing with Proteinoids and Algae

Advanced Science, EarlyView.
We developed a novel biohybrid computing system by combining proteinoid microspheres with algae. The biological mixture creates spontaneous electrical oscillations. These oscillations can perform simple logic operations, such as AND, OR, NAND, and NOR gates. Environmental factors like temperature and pH affect how the system works.
Panagiotis Mougkogiannis, Andrew Adamatzky   +1 more
wiley   +1 more source

Essential Updates 2023/2024: Recent Advances of Multimodal Approach in Patients for Gastric Cancer

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Gastric cancer remains a major global health burden, especially in East Asia. Recent years have brought significant advances in multimodal management, including surgery, perioperative chemotherapy, immunotherapy, and supportive care. This review summarizes key updates from 2023 to 2024, focusing on surgical innovations, perioperative systemic ...
Katsutoshi Shoda, Yoshihiko Kawaguchi, Suguru Maruyama, Daisuke Ichikawa   +3 more
wiley   +1 more source

Folic Acid and Vitamin B12 Administration in CKD, Why Not?

Nutrients, 2019
Patients affected by chronic kidney disease (CKD) or end-stage renal disease (ESRD) experience a huge cardiovascular risk and cardiovascular events represent the leading causes of death.
I. Capelli, G. Cianciolo, L. Gasperoni, Fulvia Zappulo, F. Tondolo, M. Cappuccilli, G. La Manna   +6 more
semanticscholar   +1 more source

Clinlabomics‐Enabled Blending Ensemble Learning for Low‐Cost Pan‐Cancer Detection and Classification Using Routine Clinical Laboratory Data

Advanced Intelligent Systems, EarlyView.
Researchers develop clinlabomics assisted for cancer identification, an artificial intelligence‐powered system using routine clinical lab data to detect and identify 10 cancer types. Tested on 19 199 individuals, it achieves 90.39% sensitivity and 82.41% specificity in cancer detection, with 72.57% accuracy in identifying specific cancer types ...
Bowen Zhang, Lin Li, Long Cheng, Yujie Liu, Zhaoqing Liu, Jiangpeng Wu, Pengyi Zhang, Jiarui Wang, Dedui Zhang, Shuyan Li   +9 more
wiley   +1 more source

Vitamin B12 and progression of white matter lesions. A 2-year follow-up study in first-ever lacunar stroke patients. [PDF]

PLoS ONE, 2013
In cross-sectional studies periventricular white matter lesions (WML) were related to low plasma levels of vitamin B12. Whether low vitamin B12 levels are also related to progression of WML is still unknown. We studied baseline vitamin B12 levels and its
Ellen C van Overbeek, Julie Staals, Robert J van Oostenbrugge   +2 more
doaj   +1 more source

Mycosis Fungoides, Sézary Syndrome, and Cutaneous B‐Cell Lymphomas: 2025 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, EarlyView.
ABSTRACT Disease Overview Primary cutaneous lymphomas are a rare and heterogeneous group of extranodal lymphomas that require the integration of clinical and histopathologic data for classification and treatment. Diagnosis Diagnosis and disease classification is based on histopathologic review and immunohistochemical staining of an appropriate skin ...
Alexandra C. Hristov, Trilokraj Tejasvi, Ryan A. Wilcox   +2 more
wiley   +1 more source

Association between Maternal Vitamin B12 Status during Pregnancy and Neonatal Outcome - A Cross-Sectional Study

Nigerian Postgraduate Medical Journal
Background: Maternal Vitamin B12 deficiency during pregnancy is associated with adverse outcomes, including preterm delivery, spontaneous abortion, intrauterine growth restriction and reduced Vitamin B12 levels in neonates.
Punjari Purna Jyothi, Manasi Garg, Venkatesh Karthik, D. Senkadhirdasan, Soundararajan Palanisamy, A R Rajasulochana   +5 more
doaj   +1 more source