Results 51 to 60 of about 10,028,727 (294)

Pharmacogenomics of vitamin K antagonists

, 2023
There is an important interindividual variability in dose requirement for coumarinic anticoagulants, which could be explained by genetic and non-genetic factors.
Letelier, Pablo, Andaur, Marcela, Vega, Mario, Guzmán Oyarzo, Dina, Boguen, Rodrigo, Guzmán, Neftalí, Reyes, Franco   +6 more
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Cost-effectiveness of dabigatran for stroke prevention in atrial fibrillation in Switzerland

Swiss Medical Weekly, 2012
OBJECTIVES: Atrial fibrillation is a major risk factor for ischemic stroke and anticoagulation therapy is indicated to reduce risk. Dabigatran is a new oral anticoagulant that does not require INR monitoring.
Mark Pletscher, Rafael Plessow, Klaus Eichler, Simon Wieser   +3 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Spontaneous Retropharyngeal and Cervical Hematoma: A Case Report

Clinical Medicine Insights: Case Reports
Background: Spontaneous Retropharyngeal Hematoma and cervical hematoma are rare conditions characterized by the accumulation of blood in the retropharyngeal and cervical region and poses a potential life-threatening risk.
Hatim Bensouda Korachi, Safa Darouich, Said Anajar, Khalid Snoussi, Mustapha Essaadi, Amal Hajjij   +5 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Vitamin K antagonism aggravates chronic kidney disease-induced neointimal hyperplasia and calcification in arterialized veins: role of vitamin K treatment?

, 2016
Arteriovenous fistula (AVF) is the common vascular access type for a hemodialysis patient. Its failure is due to neointimal hyperplasia. Vitamin K antagonists are given to lower thrombosis tendency, but have side effects that enhance arterial ...
Jacobs, Michael J., Schurgers, Leon J.; id_orcid, Koeppel, Thomas A., Hackhofer, Tina, Grommes, Jochen, Kennes, Lieven, Kranz, Jennifer, Arakelyan, Karen, Tamm, Miriam, Kokozidou, Maria, Schurgers, Leon J., Zaragatski, Emma, Kennes, Lieven Nils, Langer, Stephan   +13 more
core   +1 more source

Patients' adherence to oral anticoagulants therapy: Comparison between vitamin K antagonists and direct oral anticoagulants

, 2021
Background: Patient's adherence to oral anticoagulant therapy is essential to prevent and treat thrombotic events. Methods: To assess the patients' adherence Morisky Medication Adherence Scale 8-items was used.
Perra F., Marongiu F., Barcellona D., Cornacchini S., Farci N., Diovaldi M., Moledda V., Mameli A., Nicola Farci, Marina Diovaldi, Doris Barcellona, Francesco Marongiu, Antonella Mameli, Valentina Moledda, Flaminia Perra, Simona Cornacchini   +15 more
core   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

ADHERENCE TO THE USE OF NEW ORAL ANTICOAGULANTS IN PATIENTS WITH ATRIAL FIBRILLATION – THE WAY TO SOLVE THE PROBLEM OF EFFICACY AND SAFETY OF TREATMENT

Рациональная фармакотерапия в кардиологии, 2017
Atrial fibrillation (AF) increases the risk of stroke,  therefore long-term anticoagulant therapy is the standard for the treatment of the absolute majority of patients with this arrhythmia. Variants of anticoagulant therapy include vitamin K antagonists,
S. G. Kanorskii
doaj   +1 more source