Results 111 to 120 of about 14,521 (206)

Structural and evolutionary dissection of NADPH‐binding motifs in NADPH‐preferring ene‐reductases

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Ene‐reductases (ERs) catalyze nicotinamide‐dependent, stereoselective reductions of activated CC bonds. While their catalytic chemistry and applications are well‐explored, cosubstrate (NAD(P)H) binding remains poorly understood. Most ERs strongly prefer NADPH despite lacking canonical dinucleotide‐binding folds and instead employ flexible ...
Bianca Kerschbaumer, Eva M. Frießer, Silvia Wallner, Gustav Oberdorfer, Michael Friess, Rolf Breinbauer, Peter Macheroux, Aleksandar Bijelic   +7 more
wiley   +1 more source

In vitro, cellular and in vivo studies of amyloid oligomers structure and toxicity: Challenges and advances

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Oligomeric assemblies of amyloidogenic proteins, such as Aβ, tau, α‐synuclein, amylin, transthyretin, and TDP‐43, are increasingly recognized as key drivers of cellular dysfunction across a range of neurodegenerative and systemic disorders.
Magdalena I. Ivanova, Carmelo La Rosa, Ayyalusamy Ramamoorthy   +2 more
wiley   +1 more source

Effect of Hydroxyapatite Nanoparticles on the Ultrastructure, Developmental Competence, and Expression of <i>ZP3</i>, <i>MFN1</i>, and <i>NPM2</i> in Vitrified Bovine GV Oocytes. [PDF]

Biology (Basel)
Li XX, Zhang SY, Wang J, Wang YH, Zhang JH, Zhao SH, Cao PH, Liu YM, Zhou C, Zhang Z, Shi QT, Shakweer WME, Shakweer IME, Xu ZQ.   +13 more
europepmc   +1 more source

Supramolecular Assemblies of Self‐Immolative Janus Dendrimers With Rapid Photodegradation Response

Small, Volume 22, Issue 19, 1 April 2026.
Self‐immolative Janus dendrimers assemble into spherical nanoparticles with solid cores. Upon irradiation, rapid end‐to‐end depolymerization triggers a unique degradation pathway from spheres to crescents within minutes, enabling on‐demand release of encapsulated cargo.
Chuanfeng Li, Jiabin Luan, Daniela A. Wilson, Elizabeth R. Gillies   +3 more
wiley   +1 more source

Functional recovery of the adult murine hippocampus after cryopreservation by vitrification. [PDF]

Proc Natl Acad Sci U S A
German A, Akdaş EY, Flügel-Koch C, Erterek E, Frischknecht R, Fejtova A, Winkler J, Alzheimer C, Zheng F.   +8 more
europepmc   +1 more source

Structures of pentatricopeptide repeat proteins

Acta Crystallographica Section F, Volume 82, Issue 4, Page 101-113, April 2026.
A number of crystal, cryo‐EM and solution structures of pentatricopeptide repeat proteins have been solved, revealing details of how they interact with single‐stranded RNA and other proteins, as well as their conformational repertoire.Pentatricopeptide repeat (PPR) proteins constitute the largest family of RNA‐binding proteins in land plants, playing ...
Anuradha Pullakhandam, Crystal Cooper, Ian D. Small, Charles S. Bond   +3 more
wiley   +1 more source

Macromolecular Condensates as Tunable Scaffolds for Bio‐Inspired Silica Hybrids

Angewandte Chemie, Volume 138, Issue 14, 27 March 2026.
Dense bio‐inspired silica formation is achieved by coupling polyamine liquid–liquid phase separation with pH‐dependent silica polymerization. Silicification within polyamine condensates, enables precise control over particle size, density, and morphology.
Protap Biswas, Lior Aram, Nitzan Livni, Roman Kamyshinsky, Nadav Elad, Michal Leskes, Assaf Gal   +6 more
wiley   +2 more sources

Incorporation of lipids improves cryo-tolerance of vitrified gorgonian coral oocytes. [PDF]

PLoS One
Chen YP, Huang TF, Lo E, Tsai S, Wen ZH, Chen HK, Lin C.   +6 more
europepmc   +1 more source

Bayesian perspective for orientation determination in cryo‐EM with application to structural heterogeneity analysis

Acta Crystallographica Section D, Volume 82, Issue 4, Page 274-294, April 2026.
A Bayesian perspective on orientation estimation in cryo‐EM is presented, with the minimum mean‐square error estimator outperforming standard cross‐correlation‐based approaches, particularly under challenging low signal‐to‐noise conditions. We demonstrate that improved orientation estimation has a decisive impact on 3D reconstruction quality and ...
Sheng Xu, Amnon Balanov, Amit Singer, Tamir Bendory   +3 more
wiley   +1 more source

In vitro culture, cryopreservation, and field reintroduction of the endangered Mingan thistle

Conservation Biology, Volume 40, Issue 2, April 2026.
Abstract Current plant conservation efforts are hindered by, for example, poor seed germination, low viability, and insufficient propagation and preservation technologies. To address these problems, we devised an approach to plant conservation that integrates conservation, preservation, and restoration (CPR), which uses advanced in vitro techniques. We
Mukund R. Shukla, Wenlu Bi, Marie‐Claude Roy, Dénommée Nancy, Praveen K. Saxena   +4 more
wiley   +1 more source