Results 91 to 100 of about 7,461 (205)
Diabetes, Obesity and Metabolism, Volume 27, Issue 12, Page 6894-6904, December 2025.Abstract Aims Type 2 diabetes (T2D) is a highly heterogeneous disease characterised by subtypes with variations in aetiology, disease progression, and risk of complications. However, potential drug targets for these subtypes have not been explored. This study aims to investigate potential drug targets by integrating proteomics.
Jiahe Wei +8 more
wiley +1 more source
Characterization of the VKORC1 and CYP2C9 genotypes v3
, 2023 Vitamin K antagonists (e.g. warfarin) are anticoagulants which represent widely prescribed drugs for prevention and treatment of thromboembolic disorders. Warfarin's molecular target is vitamin K epoxide reductase enzyme and its metabolism is performed by the cytochrome P-450 2C9 enzyme, both of which are encoded by polymorphic genes - vitamin K ...
Mirsada Causevic, Honours BSc, PhD +1 more
openaire +1 more source
Journal of the American Geriatrics Society, Volume 73, Issue 12, Page 3679-3689, December 2025.This graphical abstract illustrates the annual prevalence of exposure to CPIC Level A drugs among older adults, categorized by type of pharmacogenetic recommendation. Data are presented per 1000 older individuals (A) and per 1000 prescriptions (B).
Zinan Zhao +11 more
wiley +1 more source
Characterization of the VKORC1 and CYP2C9 genotypes v4
, 2023 Vitamin K antagonists (e.g. warfarin) are anticoagulants which represent widely prescribed drugs for prevention and treatment of thromboembolic disorders. Warfarin's molecular target is vitamin K epoxide reductase enzyme and its metabolism is performed by the cytochrome P-450 2C9 enzyme, both of which are encoded by polymorphic genes - vitamin K ...
Mirsada Causevic, Honours BSc, PhD +1 more
openaire +1 more source
Detection of vkorc1 polymorphism
, 2013 Purpose: The VKORC1 polymorphism is an important genetic factor affecting warfarin dose requirement. Patients require different warfarin doses in order to achieve the target therapeutic anticoagulation. The aim of our study was to determine the frequency of single nucleotide polymorphisms (SNP) in the VKORC1gene in the general population, using a ...
Stangler Herodež, Špela +4 more
openaire +1 more source
Nonoclusive thrombosis of mechanical mitral valve prosthesis caused by inadequate treatment of anticoagulant therapy resistance [PDF]
, 2008 Background. Oral anticoagulants have been used in the prevention of thromboembolic complications for over six decades. A rare, but possible problem in the application of these medications could be resistance to them. Case report.
Cvetković-Matić Danica +3 more
core +1 more source
BMC Cardiovascular Disorders, 2018 Background The anticoagulation of atrial fibrillation catheter ablation during the perioperative stage does matter and should be treated with discretion. We aimed to assess impact of three important genes participating in vitamin K cycle (i.e.
Jiao Li +5 more
doaj +1 more source
Estandarizacion de metodo PCR-RELP para estudio de polimorfismo de vitamina K Epoxido reductasa (VKORC1 1639G>A) [PDF]
, 2010 55 p.Introducción. Polimorfismos de Vitamina K epóxido reductasa (VKORC1) han sido estudiados y se ha evidenciado que afectan en los requerimientos de dosis de anticoagulantes orales.
Avello San Martín, Jose Andrés +1 more
core
Frequencies of VKORC1 G3730A genetic variants in ischemic atherothrombotic stroke patients [PDF]
, 2015 Purpose.
Ataman, Oleksandr Vasylovych +6 more
core
Polymorphisms in genes involved in the absorption, distribution, metabolism, and excretion of drugs in the Kazakhs of Kazakhstan [PDF]
, 2016 A list of SNPs that were not found in heterozygous or homozygous variants.
Aisha N. Iskakova +5 more
core +5 more sources