Results 121 to 130 of about 63,187 (253)

Antidiabetic Effect of Tiger Nut and Coconut Blend in Experimental Type 2 Diabetic Rat Model

Phytochemicals in Food and Medicine, Volume 1, Issue 4, December 2026.
The combination of tiger nut and coconut demonstrated antihyperglycemic, antihyperlipidemic, anti‐inflammatory, and antioxidant activities on type 2 diabetic rat model over a 4‐week treatment period. ABSTRACT Tiger nut and coconut are chewy and popularly consumed as food either alone, mixed, or paired with other fruits, seeds, and vegetables.
Aminu Mohammed, Mubarak Labaran Liman
wiley   +1 more source

VLDL, Apolipoproteins B, CIII, and E, and Risk of Recurrent Coronary Events in the Cholesterol and Recurrent Events (CARE) Trial

, 2019
Background-Plasma triglyceride concentration has been an inconsistent independent risk factor for coronary heart disease, perhaps because of the metabolic heterogeneity among VLDL particles, the main carriers of triglycerides in plasma.Methods and ...
Alaupovic, P., Stampfer, Meir, Braunwald, E., Sussex, B., Moye, L. A., Sacks, F. M., Pfeffer, M. A., Cole, T. G.   +7 more
core   +1 more source

Dyslipidaemia, Chronic Kidney Disease and Diabetes Mellitus: A Triple Threat to Cardiovascular Health

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 10961-10976, December 2026.
ABSTRACT Diabetes mellitus (DM) and chronic kidney disease (CKD) frequently coexist and together create a ‘triple threat’ with dyslipidaemia, enhancing the risk for cardiovascular morbidity and mortality. Diabetic kidney disease (DKD) leads to altered lipid metabolism through insulin resistance, inflammation and oxidative stress resulting in an ...
Ann S. Forrest, Priyanka Majety, Stéphanie B. Mayer, Om P. Ganda   +3 more
wiley   +1 more source

Modification of Type III VLDL, Their Remnants, and VLDL From ApoE-Knockout Mice by p -Hydroxyphenylacetaldehyde, a Product of Myeloperoxidase Activity, Causes Marked Cholesteryl Ester Accumulation in Macrophages

, 1999
—Very low density lipoproteins (VLDLs) from apolipoprotein (apo) E2/E2 subjects with type III hyperlipoproteinemia, VLDL remnants, and VLDL from apoE-knockout (EKO) mice are taken up poorly by macrophages.
Robert A. Hegele, Jay W. Heinecke, David B. Miller, Murray W. Huff, Stewart C. Whitman, Stanley L. Hazen   +5 more
core   +1 more source

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 11143-11177, December 2026.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

Walking the VLDL tightrope in cardiometabolic diseases

Trends in Endocrinology & Metabolism
Very-low-density lipoprotein (VLDL), a triglyceride-rich lipoprotein secreted by hepatocytes, is pivotal for supplying peripheral tissues with fatty acids for energy production. As if walking on a tightrope, perturbations in the balance of VLDL metabolism contribute to cardiometabolic dysfunction, promoting pathologies such as cardiovascular disease ...
Mindy Kim, Ze Zheng
openaire   +3 more sources

New therapeutic options for metabolic‐associated steatotic liver disease

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3770-3777, November 2026.
An increasing number of patients are being diagnosed with metabolic dysfunction‐associated steatotic liver disease (MASLD). MASLD results from disturbances in hepatic lipid metabolism and is associated with an increased risk of cirrhosis and hepatocellular carcinoma and significant extrahepatic morbidity, including cardiovascular disease and ...
Tessa Straatmijer, Midas Mulder
wiley   +1 more source

A PLS‐CM and ASCA Procedure to Explore the Overlap of Two Classes

Journal of Chemometrics, Volume 40, Issue 11, November 2026.
ABSTRACT Class‐modeling (CM) and discriminant analysis (DA) are commonly applied to binary classification. DA enforces exclusive assignments of unknowns by constructing optimal delimiters, which may convey unwarranted certainty. Conversely, CM defines two class regions in the predictor space (2‐class model), allowing individuals to be assigned to one ...
O. Valencia, M. C. Ortiz, L. A. Sarabia
wiley   +1 more source

Proton Pump Inhibitor Use and Incident Epilepsy in the UK Biobank: Evidence From Pharmacovigilance and Multi‐Omics Analyses

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
Baseline PPI use was associated with a higher risk of incident epilepsy in 492,858 UK Biobank participants, with consistent evidence from active‐comparator and sensitivity analyses. FAERS, proteomic, and metabolomic findings provided complementary pharmacovigilance and molecular context, without establishing causality.
Minghao Li, Yiqian Li, Yuxi Zhang, Balkissou Seebo Saibou, Yifei Chen, Jiayi Xing, Chao Jin, Yuchen Xu, Jiahe Lin, Xinshi Wang   +9 more
wiley   +1 more source

The binding of human lipoprotein lipase treated VLDL by the human hepatoma cell line HepG2

, 1991
It has been suggested that besides the LDL-receptor, hepatocytes possess an apo E or remnant receptor. To evaluate which hepatic lipoprotein receptor is involved in VLDL remnant catabolism, we studied the binding of VLDL remnants to HepG2 cells.
Mulder, M., Wit, E.de, Havekes, L.M.
core