Results 141 to 150 of about 63,187 (253)

Protecting CEACAM1 Expression Prevents Diet‐Induced Metabolic Dysfunction and Hepatic Fibrosis in Male Mice

Obesity, Volume 34, Issue 11, Page 2094-2108, November 2026.
ABSTRACT Objective High‐fat diet represses Ceacam1 transcription via a PPARα‐mediated mechanism to cause insulin resistance before inflammation develops. The current study investigated whether mutating PPRE‐RXRα in Ceacam1 promoter prevents diet‐induced metabolic abnormalities and hepatic fibrosis in male C57BL6/J mice.
Raziyeh Abdolahipour, Saja S. Khuder, William M. Philbrick, Agnes O. Portuphy, Getachew D. Belew, Hatem G. Fallouh, Harrison T. Muturi, Boyeon Kim, Jason K. Kim, Sonia M. Najjar   +9 more
wiley   +1 more source

Interactive Effects of Dietary Crude Protein and Methionine Levels on Growth Performance, Carcass Quality and Blood Biochemistry of Japanese Quail During Starter and Grower Phases

Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.
Dietary crude protein and methionine interact significantly in Japanese quail. Optimal methionine ranges from 0.50%–0.70% depending on protein level and phase. Best grower performance occurs at 25% CP with 1.30% Met, yielding 161.84 g male weight gain. Females show superior breast yield (30.90%).
Elyas Piroz‐Maleki, Mehdi Taginejad‐Rodbaneh, Ruhollah Kianfar, Sima Moghaddaszadeh‐Ahrabi, Abolfazl Ghorbani   +4 more
wiley   +1 more source

Beta-VLDL [PDF]

, 2018
K. J. Lackner, D. Peetz
openaire   +2 more sources

Review Article: Fibrosis Reversal in Metabolic Dysfunction‐Associated Steatohepatitis—The Promise of Emerging Therapeutics

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 9, Page 1184-1196, November 2026.
Metabolic dysfunction‐associated steatohepatitis is the second commonest US indication for liver transplantation but remains largely undiagnosed and untreated. Fibrosis stage is the strongest predictor of major adverse liver outcomes, with decompensation rates and transplant‐free survival diverging sharply between F3 and F4, while cardiovascular ...
Malek Ayoub, Tsubasa Tsutsumi, Mary E. Rinella   +2 more
wiley   +1 more source

VLDL Biogenesis and Secretion

Circulation Research
The production and secretion of VLDLs (very-low-density lipoproteins) by hepatocytes has a direct impact on liver fat content, as well as the concentrations of cholesterol and triglycerides in the circulation and thus affects both liver and cardiovascular health, respectively. Importantly, insulin resistance, excess caloric intake, and lack of physical
Van Zwol, Willemien, Van De Sluis, Bart, Ginsberg, Henry N., Kuivenhoven, Jan Albert   +3 more
openaire   +1 more source

Systematic Comparison of High‐Fat Diet– and Streptozotocin‐Induced Prediabetic Obese C57BL/6J Mouse Models: A Sex‐Based Protocol Optimization Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 9897-9918, November 2026.
ABSTRACT Aims Animal models of prediabetes (Pre‐DM) are essential for studying metabolic disease and testing therapies, yet high‐fat diet (HFD) and HFD‐plus‐streptozotocin (STZ) protocols vary in feeding duration, STZ dose, and diagnostic criteria and rarely account for sex.
Min Xu, Chao Ke, Yangkun Liu, Wenying Shi, Yang Cao, Zhengyu Li, Yi Xiao, Wei Zhang   +7 more
wiley   +1 more source

GLP‐1 Receptor Agonists Post‐Bariatric Surgery (GRABS) Trial: Rationale, Design and Baseline Characteristics

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 9861-9870, November 2026.
ABSTRACT Aims No studies have investigated the synergistic effectiveness of Glucagon‐Like Peptide 1 Receptor Agonists (GLP1RAs) in patients with persistent obesity following bariatric surgery. The GLP‐1 Receptor Agonists Post‐Bariatric Surgery (GRABS) Trial aims to investigate the effectiveness of tirzepatide (TRZ) versus standard of care (SOC) after ...
J. M. Samuels, C. R. Williams, M. B. Patel, W. H. Self, L. M. Funk, C. Roumie, M. D. Spann, C. J. Northup, F. Ye, R. Irlmeier, I. Sohn, Y. Zhu, K. Niswender   +12 more
wiley   +1 more source

Recent advances in polyendocrine metabolic ovarian syndrome, formerly polycystic ovary syndrome, with emphasis on endocrine and metabolic dysfunction and cardiovascular risk

Journal of Internal Medicine, Volume 300, Issue 5, Page 590-609, November 2026.
Abstract Polyendocrine metabolic ovarian syndrome (PMOS), previously known as polycystic ovary syndrome, affects 10%–13% of women of reproductive age and remains underdiagnosed despite its substantial health burden. The introduction of the new PMOS nomenclature in 2026 reflects a fundamental shift in understanding the condition as a lifelong endocrine ...
Maria Forslund, Johanna Melin, Anju E. Joham, Terhi T. Piltonen, D. Aled Rees, Helena J. Teede   +5 more
wiley   +1 more source

ApoAV reduces plasma triglycerides by inhibiting very low density lipoprotein-triglycerides (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL-TG hydrolysis

, 2004
ApoAV has been discovered recently as a novel modifier of triglyceride (TG) metabolism, but the pathways involved are currently unknown. To gain insight into the function of apoAV, adenovirus-mediated gene transfer of murine apoa5 to C57Bl/6 mice was ...
Vliet, H.N. van der, Voshol, P.J., Chamuleau, R.A.F.M., Schaap, F.G., Groen, A.K., Dijk, K.W. van, Rensen, P.C.N., Vrins, C., Havekes, L.M.   +8 more
core  

NSG Mice Lacking Apoe: An Immunodeficient Mouse Model of Atherosclerosis

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Immunodeficient NSG mice lacking the Apoe gene develop atherosclerosis when placed on high fat diet (HFD). These mice support engraftment with human CD34+ hematopoietic stem cells. The NSG‐ApoEKO mice can be used in humanized mouse models to examine human‐specific immune disease mechanisms. Created in BioRender.
Hannah R. Megathlin, Lisa Burzenski, David A. Coleman, Blaze Albert, Michelle L. Farley, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz   +7 more
wiley   +1 more source