Results 151 to 160 of about 59,863 (274)

Chronic Exposure to Ochratoxin A Induces Metabolic Dysfunction‐Associated Steatotic Liver Disease‐Like Symptoms and Obesity With Sex‐Specific Effects in Zebrafish

Food Frontiers, Volume 7, Issue 5, September 2026.
Ochratoxin A exposure induced MASLD and obesity in a sex‐specific manner. Disruption in adipocytokine signaling pathway and vitamin D metabolism led to lipid remodeling and obesity in females. However, activation of PPAR signaling pathway and ferroptosis contributed to lipid remodeling and obesity in males.
Meng Li, Chenxi Li, Mengai He, Zhenfeng Liao, Xijiao Song, Yingqiu Mi, Hongtao Zheng, Jiayin Hou, Liezhong Chen   +8 more
wiley   +1 more source

Effects of Short‐Term Energy Limitation at Different Levels With Normal Protein Intake on Hepatic Lipid Metabolism and the Gut Microbiota in Overweight/Obese Mice

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
These findings demonstrate that with adequate protein intake, graded short‐term EL (20%–40%) effectively improves hepatic lipid metabolism and modulates gut microbiota composition in overweight/obese mice, although these regulatory effects exhibit pronounced sex‐specific differences.
Ying Tian, Yao Tang, Mingxia Gu, Jiawei Gong, Ying Zhou, Yuqing He, Keyu Huang   +6 more
wiley   +1 more source

Applying Bayesian Multivariable Mendelian Randomisation to Prioritise Candidate Causal Traits From High‐Dimensional Data: Illustration From Estimation of the Effect of Maternal Metabolites on Offspring Birthweight

Genetic Epidemiology, Volume 50, Issue 6, September 2026.
ABSTRACT Mendelian randomisation (MR) is an approach to causal inference that uses genetic variants to infer whether or not a causal effect exists, unbiased by unobserved confounding. MR estimation usually considers the effect of a single exposure on an outcome; it has recently been extended to explore potential effects of multiple exposures using ...
Ciarrah‐Jane Barry, Verena Zuber, Deborah A. Lawlor, Maria Carolina Borges, Eleanor Sanderson, Chin Yang Shapland   +5 more
wiley   +1 more source

Cardiovascular Diseases: Exploring Epidemiology, Pathophysiology, Risk Factors, and Medicinal Plant‐Based Therapies: A Narrative Review

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Cardiovascular diseases (CVDs) remain the leading cause of global morbidity and mortality, encompassing coronary artery disease, hypertension, heart failure, and cerebrovascular disorders. The global burden of CVD continues to rise, driven by complex interactions among endothelial dysfunction, oxidative stress, inflammation,
Nawfal Hasan Siam, Umme Halima Mithila, Sadia Alam Tisha, Hridoy Saha, Ayesha Binte Mahbub, Farhan Nizam, Johirul Islam, Noushin Tabasumma, Md. Mazharul Islam Chowdhury   +8 more
wiley   +1 more source

Iron‐Sulfur Cluster Targeting: A Novel Perspective for Treating Alcohol‐Related Lipid Metabolic Diseases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Alcohol metabolism induces structural instability of iron‐sulfur clusters through ROS‐mediated oxidative damage and direct covalent modification of acetaldehyde. The iron‐sulfur cluster deficiency drives metabolic reprogramming by inactivating aconitase, accumulating succinate, and impairing tRNA thiolation, thereby promoting hepatic steatosis ...
Li Xu, Zhenyang Xu, Chenli Su, Yanqian Zhao, Linjing Qiang, Xiayong Jing, Yuxiang Sun   +6 more
wiley   +1 more source

VLDL cholesterol [PDF]

, 2020
openaire   +1 more source

SEC16B identified as a regulator of VLDL secretion and lipid accumulation in the liver. [PDF]

J Clin Invest
Ardehali H.
europepmc   +1 more source

VLDL triglycerides and cholesterol in non-alcoholic fatty liver disease and myocardial infarction

Background and aims Myocardial infarction is a leading cause of death in individuals with non-alcoholic fatty liver disease (NAFLD). The two diseases share elevated very low-density lipoproteins (VLDL) carrying both triglycerides and cholesterol; however,
Tybjærg-Hansen, Anne, Nordestgaard, Børge Grønne, Nielsen, Sune Fallgaard, Smith, George Davey, Kyhl, Lærke Kristine   +4 more
core   +1 more source

GW4869 Depletes Macrophages and Increases Number of Extracellular Vesicles in Murine Peritoneal Cavity Fluid

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
ABSTRACT Pharmacological strategies to modulate extracellular vesicle (EV) release in vivo are gaining traction, yet their broader effects on local immune microenvironments remain unclear. In this study, we assessed how repeated intraperitoneal (i.p.) dosing of the neutral sphingomyelinase inhibitor GW4869 reshapes the peritoneal cavity.
Johann Mar Gudbergsson, Pedro Henrique Gobira, Rodrigo Grassi‐Oliveira, Anders Etzerodt   +3 more
wiley   +1 more source

Targeting hepatic cholesterol sensing to tackle metabolic dysfunction-associated steatohepatitis. [PDF]

J Clin Invest
Zang M, Li Y.
europepmc   +1 more source