Results 71 to 80 of about 109,603 (331)

The emergence of proton nuclear magnetic resonance metabolomics in the cardiovascular arena as viewed from a clinical perspective [PDF]

, 2014
The ability to phenotype metabolic profiles in serum has increased substantially in recent years with the advent of metabolomics. Metabolomics is the study of the metabolome, defined as those molecules with an atomic mass less than 1.5 kDa. There are two
Burgess, Karl E.V., Lawlor, Debbie A., Nelson, Scott M., Preiss, David, Rankin, Naomi J., Sattar, Naveed, Welsh, Paul   +6 more
core   +1 more source

Blood rheology, cardiovascular risk factors, and cardiovascular disease: The West of Scotland Coronary Prevention Study [PDF]

, 2000
The West of Scotland Coronary Prevention Study (WOSCOPS) showed that pravastatin reduced the risk of coronary heart disease (CHD) events in 6,595 middle-aged hypercholesterolaemic men aged 45-64 years without prior myocardial infarction followed for an ...
Ann Rumley, Christopher Packard, Gordon Lowe, Ian Ford, James Shepherd, John Norrie, null null, Peter Macfarlane, Stuart Cobbe   +8 more
core   +1 more source

Oppositely biased glucagon-like peptide-1 receptor agonism does not differentially affect lipid metabolism in APOE*3-Leiden CETP mice. [PDF]

Diabetes Obes Metab
Abstract Aims [D3,G40,K41.C16 diacid]exendin‐4 (acyl‐ExD3) and [F1,G40,K41.C16 diacid]exendin‐4 (acyl‐ExF1) are oppositely biased glucagon‐like peptide‐1 (GLP‐1) receptor agonists that preferentially promote β‐arrestin recruitment or G protein‐induced signalling, respectively.
Modder M, Tomas A, Afkir S, Pronk ACM, Streefland TCM, Lalai RA, van Eenige R, Rensen PCN, Jones B, Kooijman S.   +9 more
europepmc   +2 more sources

Bariatric surgery improves postprandial VLDL kinetics and restores insulin-mediated regulation of hepatic VLDL production

JCI Insight, 2023
Dyslipidemia in obesity results from excessive production and impaired clearance of triglyceride-rich (TG-rich) lipoproteins, which are particularly pronounced in the postprandial state. Here, we investigated the impact of Roux-en-Y gastric bypass (RYGB) surgery on postprandial VLDL1 and VLDL2 apoB and TG kinetics and their relationship with insulin ...
Vehpi Yildirim, Kasper W. ter Horst, Pim W. Gilijamse, Dewi van Harskamp, Henk Schierbeek, Hans Jansen, Alinda W.M. Schimmel, Max Nieuwdorp, Albert K. Groen, Mireille J. Serlie, Natal A.W. van Riel, Geesje M. Dallinga-Thie   +11 more
openaire   +4 more sources

Modulation by geraniol of gene expression involved in lipid metabolism leading to a reduction of serum-cholesterol and triglyceride levels [PDF]

, 2015
Background: Geraniol (G) is a natural isoprenoid present in the essential oils of several aromatic plants, with various biochemical and pharmacologic properties.
Castro, Maria Agustina, Crespo, Rosana, Galle, Marianela Edith, García de Bravo, Margarita, Lacunza, Ezequiel, Montero Villegas, Sandra, Polo, Monica Patricia, Rodenak Kladniew, Boris Emilio   +7 more
core   +2 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Inhibition of miR-33a/b in non-human primates raises plasma HDL and reduces VLDL triglycerides

Nature, 2011
Cardiovascular disease remains the leading cause of mortality in westernized countries, despite optimum medical therapy to reduce the levels of low-density lipoprotein (LDL)-associated cholesterol.
K. Rayner, Christine Esau, F. N. Hussain, Allison L. McDaniel, Stephanie M. Marshall, J. V. van Gils, T. D. Ray, Frederick J. Sheedy, L. Goedeke, Xueqing Liu, O. Khatsenko, V. Kaimal, C. Lees, C. Fernández-Hernando, E. Fisher, R. Temel, K. Moore   +16 more
semanticscholar   +1 more source

Alterations of intestinal lipoprotein metabolism in diabetes mellitus and metabolic syndrome [PDF]

, 2015
Diabetes and metabolic syndrome are associated with abnormal postprandial lipoprotein metabolism, with a significant delay in the clearance of many lipid parameters, including triglycerides and chylomicrons.
ARCA, Marcello
core   +1 more source

Depletion of Hepatic SREBP2 Protects Against Hypercholesterolemia and Atherosclerosis through the ANGPTL3‐LPL Axis

Advanced Science, EarlyView.
This study reveals a novel crosstalk between hepatic SREBP2‐mediated cholesterol biosynthesis pathway and peripheral lipoprotein lipase‐mediated lipolysis pathway in the regulation of systemic lipid metabolism. Notably, the lipid‐lowering effects of SREBP2 inhibition are independent of a functional LDL receptor, highlighting the potential of acute ...
Yifan Wang, Jia You Sarafina Choe, Yu Shi, Thi Tun Thi, Xiaoyun Cao, Yang Hu, Kai Yan Cheng, Hui Li, Yang Ji, Yan Liu, Matthew Ackers‐Johnson, Roger S.Y. Foo, Yujia Shen, Haojie Yu   +13 more
wiley   +1 more source

Regulation of VLDL synthesis and secretion in the liver [PDF]

Reproduction Nutrition Development, 1996
The production of very low density lipoproteins (VLDL) by the liver results from very complex processes that involve coordinated mechanisms of both protein and lipid synthesis and packaging. Alterations in these metabolic functions can cause negative effects on the health of human subjects or animals.
Gruffat, Dominique, Durand, Denys, Graulet, Benoit, Bauchart, Dominique   +3 more
openaire   +7 more sources