Results 71 to 80 of about 106,533 (346)
Hepatitis C virus production requires apolipoprotein A-I and affects its association with nascent low-density lipoproteins [PDF]
, 2011 Background/aims The life cycle of hepatitis C virus (HCV) is intimately linked to the lipid metabolism of the host. In particular, HCV exploits the metabolic machinery of the lipoproteins in several steps of its life cycle such as circulation in the ...
Amicone, Laura +11 more
core +1 more source
JCI Insight, 2023 Dyslipidemia in obesity results from excessive production and impaired clearance of triglyceride-rich (TG-rich) lipoproteins, which are particularly pronounced in the postprandial state. Here, we investigated the impact of Roux-en-Y gastric bypass (RYGB) surgery on postprandial VLDL1 and VLDL2 apoB and TG kinetics and their relationship with insulin ...
Vehpi Yildirim +11 more
openaire +4 more sources
Advanced Science, EarlyView.This study reveals a novel crosstalk between hepatic SREBP2‐mediated cholesterol biosynthesis pathway and peripheral lipoprotein lipase‐mediated lipolysis pathway in the regulation of systemic lipid metabolism. Notably, the lipid‐lowering effects of SREBP2 inhibition are independent of a functional LDL receptor, highlighting the potential of acute ...
Yifan Wang +13 more
wiley +1 more source
Selective Hepatic Insulin Resistance, VLDL Overproduction, and Hypertriglyceridemia
Arteriosclerosis, Thrombosis and Vascular Biology, 2012 Insulin plays a central role in regulating energy metabolism, including hepatic transport of very low-density lipoprotein (VLDL)–associated triglyceride.
J. Sparks, C. Sparks, K. Adeli
semanticscholar +1 more source
Effect of interleukin-6 receptor blockade on surrogates of vascular risk in rheumatoid arthritis: MEASURE, a randomised, placebo-controlled study [PDF]
, 2015 Objectives The interleukin-6 receptor (IL-6R) blocker tocilizumab (TCZ) reduces inflammatory disease activity in rheumatoid arthritis (RA) but elevates lipid concentrations in some patients.
Bathon, Joan M. +10 more
core +1 more source
Contemporary Perspectives on Chronic Renal Disorders
Chronic Diseases and Translational Medicine, EarlyView.ABSTRACT The prevalence of renal diseases and its associated burden on healthcare have tremendously risen in the past few years. From simple markers assessing kidney function, current renal research delves into understanding the diseases at the cellular and molecular levels and not just at treating, but at improving quality of life, arresting ...
Deenadhayalan Ashok +5 more
wiley +1 more source
Inhibition of miR-33a/b in non-human primates raises plasma HDL and reduces VLDL triglycerides
Nature, 2011 Cardiovascular disease remains the leading cause of mortality in westernized countries, despite optimum medical therapy to reduce the levels of low-density lipoprotein (LDL)-associated cholesterol.
K. Rayner +16 more
semanticscholar +1 more source
Alterations of intestinal lipoprotein metabolism in diabetes mellitus and metabolic syndrome [PDF]
, 2015 Diabetes and metabolic syndrome are associated with abnormal postprandial lipoprotein metabolism, with a significant delay in the clearance of many lipid parameters, including triglycerides and chylomicrons.
ARCA, Marcello
core +1 more source
Regulation of VLDL synthesis and secretion in the liver [PDF]
Reproduction Nutrition Development, 1996 The production of very low density lipoproteins (VLDL) by the liver results from very complex processes that involve coordinated mechanisms of both protein and lipid synthesis and packaging. Alterations in these metabolic functions can cause negative effects on the health of human subjects or animals.
Gruffat, Dominique +3 more
openaire +7 more sources
Diabetes, 2012 Excessive secretion of triglyceride-rich very low-density lipoproteins (VLDL-TG) contributes to diabetic dyslipidemia. Earlier studies have indicated a possible role for the hypothalamus and autonomic nervous system in the regulation of VLDL-TG.
E. Bruinstroop +8 more
semanticscholar +1 more source