Human Vaccines & Immunotherapeutics, 2017 Vaccine-enhanced disease has been a major obstacle in developing a safe vaccine against respiratory syncytial virus (RSV). This study demonstrates the immunogenicity, efficacy, and safety of virus-like particle (VLP) vaccines containing RSV F (F VLP), G (
Hye Suk Hwang +10 more
doaj +1 more source
Improved single-swab sample preparation for recovering bacterial and phage DNA from human skin and wound microbiomes. [PDF]
, 2019 BackgroundCharacterization of the skin and wound microbiome is of high biomedical interest, but is hampered by the low biomass of typical samples. While sample preparation from other microbiomes (e.g., gut) has been the subject of extensive optimization,
Chen, Irene A +3 more
core +1 more source
Hubble Diagram of Gamma-Rays Bursts calibrated with Gurzadyan-Xue Cosmology
, 2008 Gamma-ray bursts (GRBs) being the most luminous among known cosmic objects carry an essential potential for cosmological studies if properly used as standard candles.
Cuesta, H. J. Mosquera +5 more
core +1 more source
Profiling of Glycan Receptors for Minute Virus of Mice in Permissive Cell Lines Towards Understanding the Mechanism of Cell Recognition [PDF]
, 2013 The recognition of sialic acids by two strains of minute virus of mice (MVM), MVMp (prototype) and MVMi (immunosuppressive), is an essential requirement for successful infection.
Agbandje-McKenna, M +12 more
core +1 more source
Frontiers in Immunology, 2019 Development of effective malaria vaccines requires delivery platforms to enhance the immunogenicity and efficacy of the target antigens. This is particularly challenging for transmission-blocking malaria vaccines (TBVs), and specifically for those based ...
A. Marini +10 more
semanticscholar +1 more source
Evolution of Prime Editing: Enhancing Efficiency and Expanding Capacity
Advanced Science, EarlyView.Most rare diseases are caused by genetic mutations. Prime editing (PE) has emerged as a versatile tool capable of inducing diverse mutations without generating DNA double‐strand breaks. Despite its significant clinical potential, PE faces limitations in terms of efficiency and scalability.
Jihyeon Yu +5 more
wiley +1 more source
Robust 3D Indoor VLP System Based on ANN Using Hybrid RSS/PDOA
IEEE Access, 2019 Indoor location-based services are becoming crucial parts of smart living, smart manufacturing, and all kinds of the Internet of Things. Visible light-based positioning (VLP) system is one of the cost-efficient and RF radiation-free solutions.
S. Zhang +4 more
semanticscholar +1 more source
Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases
Advanced Science, EarlyView.This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo +5 more
wiley +1 more source
THE RECOMBINANT ANTIGENS FOR VACCINES FOR THE TREATMENT OF PAPILLOMAVIRUS (REVIEW)
Разработка и регистрация лекарственных средств, 2019 Two licensed vaccines Gardasil and Cervarix, containing main capsid protein L1 virus-like particles antigen, are used for prevention of diseases associated with human papilloma virus.
M. A. Zhuchenko
doaj
The choice of resin-bound ligand affects the structure and immunogenicity of column-purified human papillomavirus type 16 virus-like particles. [PDF]
PLoS ONE, 2012 Cell growth conditions and purification methods are important in determining biopharmaceutical activity. However, in studies aimed at manufacturing virus-like particles (VLPs) for the purpose of creating a prophylactic vaccine and antigen for human ...
Hyoung Jin Kim +3 more
doaj +1 more source