Results 61 to 70 of about 12,118 (162)

polyGR produced by CASP8 GGGAGA repeat expansion increases phosphorylation of Tau

Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.
Abstract Background Alzheimer's disease (AD) affects 6.5 million people in the United States with cases doubling by 2050. The accumulation of intracellular phosphorylated Tau tangles and amyloid beta plaques are pathological hallmarks of AD, however, the cause of these pathologies in most sporadic AD cases (∼95%) remains unclear.
Rodrigo Francisco Tomas, Huong T. Phuong, Logan R. Bell, Cemal Akamese, Lien Nguyen   +4 more
wiley   +1 more source

Genotyping of genetically monomorphic bacteria: DNA sequencing in Mycobacterium tuberculosis highlights the limitations of current methodologies.

PLoS ONE, 2009
Because genetically monomorphic bacterial pathogens harbour little DNA sequence diversity, most current genotyping techniques used to study the epidemiology of these organisms are based on mobile or repetitive genetic elements. Molecular markers commonly
Iñaki Comas, Susanne Homolka, Stefan Niemann, Sebastien Gagneux   +3 more
doaj   +1 more source

African‐origin protective haplotype for Alzheimer's disease in APOEε4 carriers

Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.
Abstract Background We have reported a statistical interaction between the African ancestry specific A allele at rs10423769 and APOEε4, where the presence of the A allele is associated with a reduction in AD risk up to 75% in APOEε4 homozygotes. The mechanism by which this variant confers protection could provide insights into new therapeutics for ...
Luciana Bertholim Nasciben, Derek Van Booven, Wanying Xu, Liyong Wang, Sofia Moura, Aura M Ramirez, Karen Nuytemans, Derek M. Dykxhoorn, Farid Rajabli, William K. Scott, David A. Davis, Regina T Vontell, Katalina F. McInerney, Michael L Cuccaro, Goldie S Byrd, Jonathan L Haines, Larry D Adams, Margaret Pericak‐Vance, Juan I Young, Fulai Jin, Anthony J Griswold, Jeffery M Vance, ADSP (Alzheimer's Disease Sequencing Project)   +22 more
wiley   +1 more source

Molecular typing of Mycobacterium Abscessus isolated from cystic fibrosis patients

International Journal of Mycobacteriology, 2017
Background: The possibility of inter-human transmission of Mycobacterium abscessus in cystic fibrosis centres has been recently hypothesized suggesting the need for the molecular characterization of strains isolated from such patients.
Alberto Trovato, Rossella Baldan, Danila Costa, Tullia M Simonetti, Daniela M Cirillo, Enrico Tortoli   +5 more
doaj   +1 more source

A Quantitative Evaluation of MIRU-VNTR Typing Against Whole-Genome Sequencing for Identifying Mycobacterium tuberculosis Transmission: A Prospective Observational Cohort Study

EBioMedicine, 2018
Background: Mycobacterial Interspersed Repetitive Unit-Variable Number Tandem Repeat (MIRU-VNTR) typing is widely used in high-income countries to determine Mycobacterium tuberculosis relatedness. Whole-genome sequencing (WGS) is known to deliver greater
David H. Wyllie, Jennifer A. Davidson, E. Grace Smith, Priti Rathod, Derrick W. Crook, Tim E.A. Peto, Esther Robinson, Tim Walker, Colin Campbell   +8 more
doaj   +1 more source

Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis.

PLoS ONE, 2016
BackgroundCarboxyl-ester lipase (CEL) contributes to fatty acid ethyl ester metabolism, which is implicated in alcoholic pancreatitis. The CEL gene harbours a variable number of tandem repeats (VNTR) region in exon 11.
Karianne Fjeld, Sebastian Beer, Marianne Johnstone, Constantin Zimmer, Joachim Mössner, Claudia Ruffert, Mario Krehan, Christian Zapf, Pål Rasmus Njølstad, Stefan Johansson, Peter Bugert, Fabio Miyajima, Triantafillos Liloglou, Laura J Brown, Simon A Winn, Kelly Davies, Diane Latawiec, Bridget K Gunson, David N Criddle, Munir Pirmohamed, Robert Grützmann, Patrick Michl, William Greenhalf, Anders Molven, Robert Sutton, Jonas Rosendahl   +25 more
doaj   +1 more source

A quantitative and efficient approach to select MIRU–VNTR loci based on accumulation of the percentage differences of strains for discriminating divergent Mycobacterium tuberculosis sublineages

Emerging Microbes and Infections, 2017
Although several optimal mycobacterial interspersed repetitive units–variable number tandem repeat (MIRU–VNTR) loci have been suggested for genotyping homogenous Mycobacterium tuberculosis, including the Beijing genotype, a more efficient and convenient ...
Xin-Ling Pan, Chun-Lei Zhang, Chie Nakajima, Jin Fu, Chang-Xia Shao, Li-Na Zhao, Jia-Yi Cui, Na Jiao, Chang-Long Fan, Yasuhiko Suzuki, Toshio Hattori, Di Li, Hong Ling   +12 more
doaj   +1 more source

INTERLEUKIN 1 AND INTERLEUKIN 4 GENES POLYMORPHISM ASSOCIATED WITH EARLY AND PRESCHOOL AGE CHILDREN SENSITIZATION TO STREPTOCOCCUS PYOGENES

Инфекция и иммунитет, 2016
Background. Streptococcus pyogenes infection and sensitization to its antigens is considered to be an unfavorable factor for the induction of rheumatic pathology. The search for genetic predictors of rheumatic diseases in general, and sensitization to S.
A. V. Shabaldin, E. V. Shabaldina, S. V. Ryazantsev, A. S. Simbirtsev   +3 more
doaj   +1 more source

Increased Risk of Gastric Cancer with VNTR Polymorphism of SIRT3 Gene

Journal of Mazandaran University of Medical Sciences, 2017
Background and purpose: Gastric cancer is the most common cancer associated with high mortality worldwide. One of the genes that is down-regulated in gastric cancer, is the SIRT3 that encodes the histone deacetylase enzyme.
Saghar Mohammadi, Parisa Mohamadynejad, Mehdi Moghanibashi   +2 more
doaj  

Genotypic diversity analysis of Mycobacterium tuberculosis strains collected from Beijing in 2009, using spoligotyping and VNTR typing.

PLoS ONE, 2014
BackgroundTuberculosis (TB) is a serious problem in China. While there have been some studies on the nationwide genotyping of Mycobacterium tuberculosis (M.
Yi Liu, Miao Tian, Xueke Wang, Rongrong Wei, Qing Xing, Tizhuang Ma, Xiaoying Jiang, Wensheng Li, Zhiguo Zhang, Yu Xue, Xuxia Zhang, Wei Wang, Tao Wang, Feng Hong, Junjie Zhang, Sumin Wang, Chuanyou Li   +16 more
doaj   +1 more source