Sodium Channels as Targets for Volatile Anesthetics [PDF]
Frontiers in Pharmacology, 2012 The molecular mechanisms of modern inhaled anesthetics although widely used in clinical settings are still poorly understood. Considerable evidence supports effects on membrane proteins such as ligand- and voltage-gated ion channels of excitable cells ...
Karl F Herold, Hugh C Hemmings
exaly +9 more sources
Volatile Anesthetics Regulate Anti-Cancer Relevant Signaling [PDF]
Frontiers in Oncology, 2021 Volatile anesthetics are widely used inhalation anesthetics in clinical anesthesia. In recent years, the regulation of anti-cancer relevant signaling of volatile anesthetics has drawn the attention of investigators.
Chien-shan Cheng
exaly +4 more sources
Volatile anesthetics affect macrophage phagocytosis. [PDF]
PLoS ONE, 2019 BackgroundPerioperative infections, particularly surgical site infections pose significant morbidity and mortality. Phagocytosis is a critical step for microbial eradication.
Hui Zha +10 more
doaj +5 more sources
The effects of volatile anesthetics and propofol in patients undergoing off-pump coronary artery bypass grafting: a systematic review and meta-analysis [PDF]
Frontiers in Cardiovascular Medicine, 2023 BackgroundStudies investigating the cardioprotective effect of volatile anesthetics on cardiac troponins in off-pump coronary artery bypass grafting (OPCAB) surgery remain controversial.
Chenghong Zhang +6 more
doaj +2 more sources
Development of NMDA receptors contributes to the enhancement of electroencephalogram oscillations under volatile anesthetics in rats [PDF]
Frontiers in Neural Circuits, 2022 BackgroundVolatile anesthetics including sevoflurane and isoflurane enhance oscillations of cortical electroencephalogram (EEG), partly by their modulations on glutamate-mediated excitatory synaptic transmission. Expression of NMDA receptors is increased
Mingyue Zhang +11 more
doaj +2 more sources
Effects of Volatile Anesthetics on Postoperative Ischemic Stroke Incidence [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background Preclinical studies suggest that volatile anesthetics decrease infarct volume and improve the outcome of ischemic stroke. This study aims to determine their effect during noncardiac surgery on postoperative ischemic stroke incidence.
Dana Raub +11 more
doaj +2 more sources
Altered anesthetic sensitivity of mice lacking Ndufs4, a subunit of mitochondrial complex I. [PDF]
PLoS ONE, 2012 Anesthetics are in routine use, yet the mechanisms underlying their function are incompletely understood. Studies in vitro demonstrate that both GABA(A) and NMDA receptors are modulated by anesthetics, but whole animal models have not supported the role ...
Albert Quintana +4 more
doaj +9 more sources
The effect of volatile anesthetics on cellular responses in the microcirculation of free tissue transfers [PDF]
Advances in Interventional Cardiology, 2021 The purpose of this review was to summarize the anti-inflammatory and immunosuppressive properties of volatile anesthetics and present their potential impact on the outcomes of major surgical procedures as well as microsurgical cases of free tissue ...
Jakub Szrama +4 more
doaj +2 more sources
Mechanisms underlying neonate-specific metabolic effects of volatile anesthetics [PDF]
eLife, 2021 Volatile anesthetics (VAs) are widely used in medicine, but the mechanisms underlying their effects remain ill-defined. Though routine anesthesia is safe in healthy individuals, instances of sensitivity are well documented, and there has been significant
Julia Stokes +13 more
doaj +2 more sources
Nephrotoxicity and Modern Volatile Anesthetics: A Narrative Review [PDF]
ToxicsVolatile anesthetics, while increasingly utilized in intensive care medicine, are associated with significant renal adverse effects. A critical safety concern—particularly with sevoflurane—involves its potential impact on renal function ...
Benedicte Hauquiert +15 more
doaj +2 more sources