Volatile anesthetics affect macrophage phagocytosis. [PDF]
PLoS ONE, 2019 BackgroundPerioperative infections, particularly surgical site infections pose significant morbidity and mortality. Phagocytosis is a critical step for microbial eradication.
Hui Zha +10 more
doaj +5 more sources
The effects of volatile anesthetics and propofol in patients undergoing off-pump coronary artery bypass grafting: a systematic review and meta-analysis [PDF]
Frontiers in Cardiovascular Medicine, 2023 BackgroundStudies investigating the cardioprotective effect of volatile anesthetics on cardiac troponins in off-pump coronary artery bypass grafting (OPCAB) surgery remain controversial.
Chenghong Zhang +6 more
doaj +2 more sources
Volatile Anesthetics Regulate Anti-Cancer Relevant Signaling [PDF]
Frontiers in Oncology, 2021 Volatile anesthetics are widely used inhalation anesthetics in clinical anesthesia. In recent years, the regulation of anti-cancer relevant signaling of volatile anesthetics has drawn the attention of investigators.
Jiaqiang Wang +5 more
doaj +2 more sources
Development of NMDA receptors contributes to the enhancement of electroencephalogram oscillations under volatile anesthetics in rats [PDF]
Frontiers in Neural Circuits, 2022 BackgroundVolatile anesthetics including sevoflurane and isoflurane enhance oscillations of cortical electroencephalogram (EEG), partly by their modulations on glutamate-mediated excitatory synaptic transmission. Expression of NMDA receptors is increased
Mingyue Zhang +11 more
doaj +2 more sources
Altered anesthetic sensitivity of mice lacking Ndufs4, a subunit of mitochondrial complex I. [PDF]
PLoS ONE, 2012 Anesthetics are in routine use, yet the mechanisms underlying their function are incompletely understood. Studies in vitro demonstrate that both GABA(A) and NMDA receptors are modulated by anesthetics, but whole animal models have not supported the role ...
Albert Quintana +4 more
doaj +8 more sources
Sodium channels as targets for volatile anesthetics [PDF]
Frontiers in Pharmacology, 2012 The molecular mechanisms of modern inhaled anesthetics although widely used in clinical settings are still poorly understood. Considerable evidence supports effects on membrane proteins such as ligand- and voltage-gated ion channels of excitable cells ...
Karl F. Herold, Hugh C. Hemmings
doaj +3 more sources
Volatile anesthetics as a neuroprotective agent [PDF]
Korean Journal of Anesthesiology, 2011 Pharmacologic protection of brain from ischemic insult has been intensively investigated since the early 1960s [1] and a considerable amount of work has been performed to show the effectiveness of various drugs. Among these studies, anesthetic agents, including intravenous and volatile drugs, were shown to be promising agents.
Sungsik Park
doaj +5 more sources
Effects of Volatile Anesthetics on Postoperative Ischemic Stroke Incidence [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background Preclinical studies suggest that volatile anesthetics decrease infarct volume and improve the outcome of ischemic stroke. This study aims to determine their effect during noncardiac surgery on postoperative ischemic stroke incidence.
Dana Raub +11 more
doaj +2 more sources
Prolonged in vitro anti-bacterial, anti-inflammatory, and surfactant-promoting effects of volatile anesthetics [PDF]
BMC Pulmonary MedicineBackground Volatile anesthetics are gaining recognition for their benefits in long-term sedation of mechanically ventilated patients with bacterial pneumonia and acute respiratory distress syndrome.
Claudia Scheffzük +6 more
doaj +2 more sources
Volatile anesthetics and ischemia-reperfusion injury [PDF]
Korean Journal of Anesthesiology, 2015 Ischemia-reperfusion (IR) injury can occur under various clinical conditions in which the restoration of blood and oxygen to ischemic tissues results in a massive release of oxygen free radicals. For example, cardiac surgery, stroke, tourniquet application for orthopedic surgery, organ transplantation, and restoration of shock can cause IR injury ...
Hong-Beom Bae
doaj +4 more sources