Results 31 to 40 of about 10,634 (223)

Low dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus. [PDF]

, 2012
The anesthetic excitement phase occurring during induction of anesthesia with volatile anesthetics is a well-known phenomenon in clinical practice. However, the physiological mechanisms underlying anesthetic-induced excitation are still unclear.
Dodt Hans-Ulrich, Hans-Ulrich Dodt, Eder, Matthias, Ranft, Andreas, Ludwig von Meyer, Zieglgänsberger Walter, Ranft Andreas, von Meyer, Ludwig, Klaus Becker, Eberhard Kochs, Becker, K., Walter Zieglgänsberger, Kochs Eberhard, Matthias Eder, Kochs, Eberhard, Becker Klaus, Andreas Ranft, von Meyer, L., Dodt, H., Dodt, H. U., Becker, Klaus, Zieglgänsberger, Walter, Eder, M., Eder Matthias, Zieglgänsberger, W., Meyer, Ludwig von, von Meyer Ludwig, Dodt, Hans-Ulrich, Ranft, A., Kochs, E.   +29 more
core   +1 more source

Altered anesthetic sensitivity of mice lacking Ndufs4, a subunit of mitochondrial complex I. [PDF]

PLoS ONE, 2012
Anesthetics are in routine use, yet the mechanisms underlying their function are incompletely understood. Studies in vitro demonstrate that both GABA(A) and NMDA receptors are modulated by anesthetics, but whole animal models have not supported the role ...
Albert Quintana, Philip G Morgan, Shane E Kruse, Richard D Palmiter, Margaret M Sedensky   +4 more
doaj   +1 more source

The volatile anesthetic isoflurane differentially inhibits voltage-gated sodium channel currents between pyramidal and parvalbumin neurons in the prefrontal cortex

Frontiers in Neural Circuits, 2023
BackgroundHow volatile anesthetics work remains poorly understood. Modulations of synaptic neurotransmission are the direct cellular mechanisms of volatile anesthetics in the central nervous system.
Jingxuan Qiu, Jingxuan Qiu, Yaoxin Yang, Yaoxin Yang, Jin Liu, Wenling Zhao, Qian Li, Qian Li, Tao Zhu, Peng Liang, Cheng Zhou   +10 more
doaj   +1 more source

Volatile anesthetics suppress glucose-stimulated insulin secretion in MIN6 cells by inhibiting glucose-induced activation of hypoxia-inducible factor 1 [PDF]

PeerJ, 2015
Proper glycemic control is one of the most important goals in perioperative patient management. Insulin secretion from pancreatic β-cells in response to an increased blood glucose concentration plays the most critical role in glycemic control.
Kengo Suzuki, Yoshifumi Sato, Shinichi Kai, Kenichiro Nishi, Takehiko Adachi, Yoshiyuki Matsuo, Kiichi Hirota   +6 more
doaj   +2 more sources

Immune Modulation by Volatile Anesthetics [PDF]

Anesthesiology, 2016
Abstract Volatile general anesthetics continue to be an important part of clinical anesthesia worldwide. The impact of volatile anesthetics on the immune system has been investigated at both mechanistic and clinical levels, but previous studies have returned conflicting findings due to varied protocols, experimental environments, and subject ...
Lindsay M, Stollings, Li-Jie, Jia, Pei, Tang, Huanyu, Dou, Binfeng, Lu, Yan, Xu   +5 more
openaire   +2 more sources

SLO-2 is cytoprotective and contributes to mitochondrial potassium transport. [PDF]

PLoS ONE, 2011
Mitochondrial potassium channels are important mediators of cell protection against stress. The mitochondrial large-conductance "big" K(+) channel (mBK) mediates the evolutionarily-conserved process of anesthetic preconditioning (APC), wherein exposure ...
Andrew P Wojtovich, Teresa A Sherman, Sergiy M Nadtochiy, William R Urciuoli, Paul S Brookes, Keith Nehrke   +5 more
doaj   +1 more source

The role of Volatile Anesthetics in Cardioprotection: a systematic review [PDF]

, 2012
This review evaluates the mechanism of volatile anesthetics as cardioprotective agents in both clinical and laboratory research and furthermore assesses possible cardiac side effects upon usage.
Arthur S Leitzke, Jiping Tang, Paul R Krafft, John H Zhang, Van Allen, Nicole R, Applegate, Richard L, Richard L Applegate, Zhang, John H, Krafft, Paul R, Tang, Jiping, Nicole R Van Allen, Leitzke, Arthur S   +11 more
core   +1 more source

A Double-Edged Sword: Volatile Anesthetic Effects on the Neonatal Brain

Brain Sciences, 2014
The use of volatile anesthetics, a group of general anesthetics, is an exceedingly common practice. These anesthetics may have neuroprotective effects. Over the last decade, anesthetic induced neurotoxicity in pediatric populations has gained a certain ...
Sunny Chiao, Zhiyi Zuo
doaj   +1 more source

Impact of anesthetic agents on the amount of bleeding during dilatation and evacuation: A systematic review and meta-analysis.

PLoS ONE, 2021
PurposePatients undergo dilatation and evacuation for abortion or miscarriage. However, bleeding is sometimes problematic. Despite reports on the association between volatile anesthetics and increased bleeding during the procedure, firm evidence is ...
Hyun Ah Lee, Hiromasa Kawakami, Takahiro Mihara, Hitoshi Sato, Takahisa Goto   +4 more
doaj   +1 more source

Volatile anesthetics versus total intravenous anesthesia in patients undergoing coronary artery bypass grafting: An updated meta-analysis and trial sequential analysis of randomized controlled trials.

PLoS ONE, 2019
BACKGROUND:The benefits of volatile anesthetics in coronary artery bypass grafting (CABG) patients remain controversial. We aimed to conduct an updated meta-analysis to assess whether the use of volatile anesthetics during CABG could reduce mortality and
Xue-Feng Jiao, Xue-Mei Lin, Xiao-Feng Ni, Hai-Long Li, Chuan Zhang, Chun-Song Yang, Hao-Xin Song, Qiu-Sha Yi, Ling-Li Zhang   +8 more
doaj   +1 more source