Results 11 to 20 of about 694,198 (334)

Sedating Mechanically Ventilated COVID-19 Patients with Volatile Anesthetics: Insights on the Last-Minute Potential Weapons

Scientia Pharmaceutica, 2021
Coronavirus Disease 2019 (COVID-19) has spread globally with the number of cases exceeding seventy million. Although trials on potential treatments of COVID-19 Acute Respiratory Distress Syndrome (ARDS) are promising, the introduction of an effective ...
Aiman Suleiman, Abdallah Barjas Qaswal, Mazen Alnouti, Moh’d Yousef, Bayan Suleiman, Mohammad El Jarbeh, Ghadeer Alshawabkeh, Isam Bsisu, Abeer Santarisi, Muaweih Ababneh   +9 more
doaj   +2 more sources

Volatile anesthetics versus total intravenous anesthesia in patients undergoing coronary artery bypass grafting: An updated meta-analysis and trial sequential analysis of randomized controlled trials.

PLoS ONE, 2019
BACKGROUND:The benefits of volatile anesthetics in coronary artery bypass grafting (CABG) patients remain controversial. We aimed to conduct an updated meta-analysis to assess whether the use of volatile anesthetics during CABG could reduce mortality and
Xue-Feng Jiao, Xue-Mei Lin, Xiao-Feng Ni, Hai-Long Li, Chuan Zhang, Chun-Song Yang, Hao-Xin Song, Qiu-Sha Yi, Ling-Li Zhang   +8 more
doaj   +2 more sources

Relationship between volatile anesthetics and functional outcomes in patients with subarachnoid hemorrhage [PDF]

Journal of Anesthesia, Analgesia and Critical Care
Background Volatile anesthetics have been suggested to exert neuroprotective effects in patients with subarachnoid hemorrhage caused by a ruptured cerebral aneurysm. However, their effects on functional outcomes remain unverified.
Yudai Iwasaki, Kunio Tarasawa, Yu Kaiho, Saori Ikumi, Takahiro Imaizumi, Shizuha Yabuki, Kiyohide Fushimi, Kenji Fujimori, Masanori Yamauchi   +8 more
doaj   +2 more sources

Immune Modulation by Volatile Anesthetics [PDF]

Anesthesiology, 2016
Abstract Volatile general anesthetics continue to be an important part of clinical anesthesia worldwide. The impact of volatile anesthetics on the immune system has been investigated at both mechanistic and clinical levels, but previous studies have returned conflicting findings due to varied protocols, experimental environments, and subject ...
Lindsay Stollings, Li-jie Jia, P. Tang, H. Dou, B. Lu, Yan Xu   +5 more
semanticscholar   +3 more sources

Development of NMDA receptors contributes to the enhancement of electroencephalogram oscillations under volatile anesthetics in rats [PDF]

Frontiers in Neural Circuits, 2022
BackgroundVolatile anesthetics including sevoflurane and isoflurane enhance oscillations of cortical electroencephalogram (EEG), partly by their modulations on glutamate-mediated excitatory synaptic transmission. Expression of NMDA receptors is increased
Mingyue Zhang, Mingyue Zhang, Yali Chen, Yali Chen, Jin Liu, Jin Liu, Yaoxin Yang, Yaoxin Yang, Rurong Wang, Donghang Zhang, Donghang Zhang, Tao Zhu   +11 more
doaj   +2 more sources

Altered anesthetic sensitivity of mice lacking Ndufs4, a subunit of mitochondrial complex I. [PDF]

PLoS ONE, 2012
Anesthetics are in routine use, yet the mechanisms underlying their function are incompletely understood. Studies in vitro demonstrate that both GABA(A) and NMDA receptors are modulated by anesthetics, but whole animal models have not supported the role ...
Albert Quintana, Philip G Morgan, Shane E Kruse, Richard D Palmiter, Margaret M Sedensky   +4 more
doaj   +8 more sources

Volatile Anesthetics Activate a Leak Sodium Conductance in Retrotrapezoid Nucleus Neurons to Maintain Breathing during Anesthesia in Mice. [PDF]

Anesthesiology, 2020
Background: Volatile anesthetics moderately depress respiratory function at clinically relevant concentrations. Phox2b-expressing chemosensitive neurons in the retrotrapezoid nucleus, a respiratory control center, are activated by isoflurane, but the ...
Yang Y, Ou M, Liu J, Zhao W, Zhuoma L, Liang Y, Zhu T, Mulkey DK, Zhou C.   +8 more
europepmc   +2 more sources

Prolonged in vitro anti-bacterial, anti-inflammatory, and surfactant-promoting effects of volatile anesthetics [PDF]

BMC Pulmonary Medicine
Background Volatile anesthetics are gaining recognition for their benefits in long-term sedation of mechanically ventilated patients with bacterial pneumonia and acute respiratory distress syndrome.
Claudia Scheffzük, Johanna Lührmann, Robin Brinkmann, Dominika Biedziak, Kristina Gloystein, Patrick Kellner, Cordula Stamme   +6 more
doaj   +2 more sources

Mitochondrial targets for volatile anesthetics against cardiac ischemia-reperfusion injury [PDF]

Frontiers in Physiology, 2014
Mitochondria are critical modulators of cell function and are increasingly recognized as proximal sensors and effectors that ultimately determine the balance between cell survival and cell death.
Bhawana Agarwal, David F. Stowe, Ranjan K. Dash, Zeljko J. Bosnjak, Amadou K.S. Camara   +4 more
openalex   +2 more sources

The effect of volatile anesthetics on cellular responses in the microcirculation of free tissue transfers [PDF]

Advances in Interventional Cardiology, 2021
The purpose of this review was to summarize the anti-inflammatory and immunosuppressive properties of volatile anesthetics and present their potential impact on the outcomes of major surgical procedures as well as microsurgical cases of free tissue ...
Jakub Szrama, Krzysztof Kusza, Paweł Sobczyński, Zsolt Molnar, Maria Siemionow   +4 more
doaj   +2 more sources