Results 71 to 80 of about 71,736 (190)

Single-channel recordings from cultured human retinal pigment epithelial cells. [PDF]

, 1988
We have applied patch-clamp techniques to on-cell and excised-membrane patches from human retinal pigment epithelial cells in tissue culture. Single-channel currents from at least four ion channel types were observed: three or more potassium-selective ...
Fain, GL, Fox, JA, Pfeffer, BA
core  

Age-dependent posttranslational modifications of voltage-dependent anion channel 1

Experimental Gerontology, 2010
The accumulation of oxidative damage in mitochondrial proteins, membranes and DNA during ageing is supposed to lead to mitochondrial inactivation, downstream molecular impairments and subsequent decline of biological systems. In a quantitative study investigating the age-related changes of mitochondrial proteins on the level of oxidative ...
Karlfried, Groebe, Martina, Klemm-Manns, Gerhard P, Schwall, Heiko, Hübenthal, Herrmann, Unterluggauer, Pidder, Jansen-Dürr, Robert M, Tanguay, Geneviève, Morrow, André, Schrattenholz   +8 more
openaire   +2 more sources

Over Expression of Voltage Dependent Anion Channel 2 (VDAC2) in Muscles of Electrically Stunned Chickens

International Islamic University Malaysia Engineering Journal, 2011
Water bath stunning is a common practice in commercial slaughterhouses. Such treatment is economic and in line with animal welfare practice. However, the conditions applied for the stunning process may vary from a slaughterhouse to another slaughterhouse.
Norshahida Abu Samah, Azura Amid, and Faridah Yusof
doaj   +1 more source

Structural basis for malate-driven, pore lipid-regulated activation of the Arabidopsis vacuolar anion channel ALMT9

Nature Communications
In plant cells, ALMTs are key plasma and vacuolar membrane-localized anion channels regulating plant responses to the environment. Vacuolar ALMTs control anion accumulation in plant cells and, in guard cells, they regulate stomata aperture.
Yeongmok Lee, Elsa Demes-Causse, Jaemin Yoo, Seo Young Jang, Seoyeon Jung, Justyna Jaślan, Geum-Sook Hwang, Jejoong Yoo, Alexis De Angeli, Sangho Lee   +9 more
doaj   +1 more source

Redox-dependent gating of VDAC by mitoNEET. [PDF]

, 2019
MitoNEET is an outer mitochondrial membrane protein essential for sensing and regulation of iron and reactive oxygen species (ROS) homeostasis. It is a key player in multiple human maladies including diabetes, cancer, neurodegeneration, and Parkinson's ...
Bai, Fang, Jennings, Patricia A, Lipper, Colin H, Mittler, Ron, Nechushtai, Rachel, Onuchic, José N, Roy, Susmita, Sohn, Yang-Sung, Stofleth, Jason T   +8 more
core  

TRPC1 regulates calcium-activated chloride channels in salivary gland cells [PDF]

, 2015
Calcium-activated chloride channel (CaCC) plays an important role in modulating epithelial secretion. It has been suggested that in salivary tissues, sustained fluid secretion is dependent on Ca2+ influx that activates ion channels such as CaCC to ...
Birnbaumer, Lutz, Singh, Brij B., Sun, Yuyang   +2 more
core   +1 more source

Ryanodine receptors are targeted by anti-apoptotic Bcl-X-L involving its BH4 domain and Lys87 from its BH3 domain [PDF]

, 2015
Anti-apoptotic B-cell lymphoma 2 (Bcl-2) family members target several intracellular Ca2+-transport systems. Bcl-2, via its N-terminal Bcl-2 homology (BH) 4 domain, inhibits both inositol 1,4,5-trisphosphate receptors (IP(3)Rs) and ryanodine receptors ...
Bultynck, Geert, De Smedt, Humbert, Decrock, Elke, Ivanova, Hristina, Kasri, Nael Nadif, Lemmens, Irma, Leybaert, Luc, Martens, Lennart, Missiaen, Ludwig, Monaco, Giovanni, Parys, Jan B, Sorrentino, Vincenzo, Tavernier, Jan, Vandermarliere, Elien, Vervliet, Tim   +14 more
core   +1 more source

The mitochondrial voltage-dependent anion channel 1 in tumor cells

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2015
VDAC1 is found at the crossroads of metabolic and survival pathways. VDAC1 controls metabolic cross-talk between mitochondria and the rest of the cell by allowing the influx and efflux of metabolites, ions, nucleotides, Ca2+ and more. The location of VDAC1 at the outer mitochondrial membrane also enables its interaction with proteins that mediate and ...
Shoshan-Barmatz, Varda, Ben-Hail, Danya, Admoni, Lee, Krelin, Yakov, Tripathi, Shambhoo Sharan   +4 more
openaire   +2 more sources

Ph-Induced Oligomerization of the Voltage Dependent Anion Channel [PDF]

Biophysical Journal, 2017
The Voltage-Dependent Anion Channel (VDAC) is the most abundant protein in the outer mitochondrial membrane facilitating the passage of ions and metabolites between the cytoplasm and the intermembrane space. In addition to its critical role in bioenergetics, VDAC is capable of modulating the organelle's permeability, implicating VDAC in metabolic ...
Lucie A. Bergdoll, Michael T. Lerch, Kendrick Belardo, Christian Altenbach, Paola Bisignano, Michael Grabe, Wayne Hubbell, Jeff Abramson   +7 more
openaire   +1 more source

Cell demise inhibited: Unexpected liaisons between mitochondria and IκΒα

Molecular & Cellular Oncology, 2021
IκΒα (the protein product of NFKBIA gene) has widely been considered a pro- apoptotic factor due to its ability to inhibit the anti-apoptotic transcription factor NFκB.
Evangelos Pazarentzos
doaj   +1 more source