Results 51 to 60 of about 4,682,761 (283)
Voltage-dependent anion channels: different isoforms for different functions [PDF]
, 2009 The Voltage-dependent anion channel (VDAC) is the most abundant protein of the outer mitochondrial membrane (OMM) and mediates the flow of ions and metabolites between the cytoplasm and the mitochondrial network.
DE STEFANI, Diego, De Stefani, D.
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Subcellular Localization of Human Voltage-dependent Anion Channel Isoforms [PDF]
Journal of Biological Chemistry, 1995 The voltage-dependent anion channel of the outer mitochondrial membrane, VDAC (also known as mitochondrial porin), is a small abundant protein which forms a voltage-gated pore when incorporated into planar lipid bilayers. This protein forms the primary pathway for movement of major metabolites through the outer membrane.
W H, Yu, W, Wolfgang, M, Forte
openaire +2 more sources
Voltage-Dependent Anion Channel 1 As an Emerging Drug Target for Novel Anti-Cancer Therapeutics
Frontiers in Oncology, 2017 Cancer cells share several properties, high proliferation potential, reprogramed metabolism, and resistance to apoptotic cues. Acquiring these hallmarks involves changes in key oncogenes and non-oncogenes essential for cancer cell survival and prosperity,
Varda Shoshan-Barmatz +3 more
doaj +1 more source
Cepharanthine induces ROS stress in glioma and neuronal cells via modulation of VDAC permeability
Saudi Pharmaceutical Journal, 2020 Cepharanthine (CEP) is a bisbenzylisoquinoline alkaloid. Molecular dynamics studies show that CEP interacts with Voltage-dependent anion channel (VDAC), inducing the voltage-independent channel narrowing.
Karolina Cierluk +6 more
doaj +1 more source
Lidocaine promotes apoptosis in breast cancer cells by affecting VDAC1 expression
BMC Anesthesiology, 2022 Objective To investigate the effect of lidocaine on the expression of voltage-dependent anion channel 1 (VDAC1) in breast invasive carcinoma (BRCA) and its impact on the apoptosis of breast cancer cells.
Dingde Long +5 more
doaj +1 more source
Systems dynamic modeling of a guard cell Cl- channel mutant uncovers an emergent homeostatic network regulating stomatal transpiration [PDF]
, 2012 Stomata account for much of the 70% of global water usage associated with agriculture and have a profound impact on the water and carbon cycles of the world.
Yizhou Wang +15 more
core +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Investigating the oxidoreductase activity of members of the chloride intracellular ion channel protein family [PDF]
, 2019 University of Technology Sydney. Faculty of Science.The chloride intracellular ion channel (CLICs) proteins are atypical anion selective channel proteins, as they are principally soluble proteins, with some members now known to also demonstrate enzymatic
Ali, Hala Mishaal
core
Age-dependent prosttranslational modifications of voltage-dependent anion channel 1
, 2010 The accumulation of oxidative damage in mitochondrial proteins, membranes and DNA during ageing is supposed to lead to mitochondrial inactivation, downstream molecular impairments and subsequent decline of biological systems.In a quantitative study ...
Klemm-Manns, Martina +8 more
core +1 more source