A role for voltage-dependent anion channel Vdac1 in polyglutamine-mediated neuronal cell death. [PDF]
PLoS ONE, 2007 Expansion of trinucleotide repeats in coding and non-coding regions of genes is associated with sixteen neurodegenerative disorders. However, the molecular effects that lead to neurodegeneration have remained elusive.
Tanay Ghosh +4 more
doaj +1 more source
Porin 1 Modulates Autophagy in Yeast
Cells, 2021 Autophagy is a cellular recycling program which efficiently reduces the cellular burden of ageing. Autophagy is characterised by nucleation of isolation membranes, which grow in size and further expand to form autophagosomes, engulfing cellular material ...
Filomena Broeskamp +9 more
doaj +1 more source
AtALMT12 represents an R-type anion channel required for stomatal movement in Arabidopsis guard cells [PDF]
, 2010 Stomatal pores formed by a pair of guard cells in the leaf epidermis control gas exchange and transpirational water loss. Stomatal closure is mediated by the release of potassium and anions from guard cells. Anion efflux from guard cells involves slow (S-
Al-Rasheid, K A S +9 more
core +1 more source
Protocol: optimised electrophyiological analysis of intact guard cells from arabidopsis [PDF]
, 2012 Genetic resources available for Arabidopsis thaliana make this species particularly attractive as a model for molecular genetic studies of guard cell homeostasis, transport and signalling, but this facility is not matched by accessible tools for ...
Blatt, M.R. +4 more
core +3 more sources
Role of physiological ClC-1 Cl- ion channel regulation for the excitability and function of working skeletal muscle. [PDF]
, 2016 Electrical membrane properties of skeletal muscle fibers have been thoroughly studied over the last five to six decades. This has shown that muscle fibers from a wide range of species, including fish, amphibians, reptiles, birds, and mammals, are all ...
Chen, Tsung-Yu +4 more
core +1 more source
Neuronal and astroglial correlates underlying spatiotemporal Intrinsic Optical Signal in the rat hippocampal slice [PDF]
, 2013 Widely used for mapping afferent activated brain areas in vivo, the label-free intrinsic optical signal (IOS) is mainly ascribed to blood volume changes subsequent to glial glutamate uptake.
Héja, László +3 more
core +6 more sources
Single-channel measurements of an N-acetylneuraminic acid-inducible outer membrane channel in Escherichia coli [PDF]
, 2012 NanC is an Escherichia coli outer membrane protein involved in sialic acid (Neu5Ac, i.e., N-acetylneuraminic acid) uptake. Expression of the NanC gene is induced and controlled by Neu5Ac. The transport mechanism of Neu5Ac is not known.
Eisenberg, Bob +4 more
core +1 more source
β-Barrel Mobility Underlies Closure of the Voltage-Dependent Anion Channel [PDF]
Structure, 2012 The voltage-dependent anion channel (VDAC) is the major protein in the outer mitochondrial membrane, where it mediates transport of ATP and ADP. Changes in its permeability, induced by voltage or apoptosis-related proteins, have been implicated in apoptotic pathways.
Zachariae, Ulrich +12 more
openaire +5 more sources
Concentration dependent ion selectivity in VDAC: a molecular dynamics simulation study. [PDF]
PLoS ONE, 2011 The voltage-dependent anion channel (VDAC) forms the major pore in the outer mitochondrial membrane. Its high conducting open state features a moderate anion selectivity.
Eva-Maria Krammer +2 more
doaj +1 more source
TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control [PDF]
, 2014 The 18-kDa TSPO (translocator protein) localizes on the outer mitochondrial membrane (OMM) and participates in cholesterol transport. Here, we report that TSPO inhibits mitochondrial autophagy downstream of the PINK1-PARK2 pathway, preventing essential ...
Anholt R +22 more
core +3 more sources