Results 11 to 20 of about 4,682,761 (283)

Structure, gating and interactions of the voltage-dependent anion channel. [PDF]

Eur Biophys J, 2021
The voltage-dependent anion channel (VDAC) is one of the most highly abundant proteins found in the outer mitochondrial membrane, and was one of the earliest discovered. Here we review progress in understanding VDAC function with a focus on its structure,
Najbauer EE, Becker S, Giller K, Zweckstetter M, Lange A, Steinem C, de Groot BL, Griesinger C, Andreas LB.   +8 more
europepmc   +9 more sources

VDAC1 (voltage-dependent anion channel 1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on VDAC1 (voltage-dependent anion channel 1), with data on DNA, on the protein encoded, and where the gene is ...
Shoshan-Barmatz, V, Mizrachi, D
core   +4 more sources

Structure of the human voltage-dependent anion channel. [PDF]

Proceedings of the National Academy of Sciences, 2008
The voltage-dependent anion channel (VDAC), also known as mitochondrial porin, is the most abundant protein in the mitochondrial outer membrane (MOM).
Vonrhein, C., Giller, K., Habeck, M. ; https://orcid.org/, Zeth, K., Villinger, S., Bayrhuber, M., Becker , S., Becker, Stefan, Zweckstetter, Markus, Villinger , S., Giller, Karin, Zweckstetter, M., Villinger, Saskia, Becker, S., Bayrhuber, Monika, Habeck, Michael, Meins, Thomas, Griesinger, C., Vonrhein, Clemens, Zeth, Kornelius, Meins, T., Griesinger, Christian, Habeck, M.   +22 more
core   +9 more sources

Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis [PDF]

Nature Communications, 2021
The authors found that VDAC2 plays a crucial role in influencing mitochondrial calcium dynamics and cellular calcium signalling. A VDAC2 agonist, efsevin, rescued the heart failure phenotype, identifying a new potential therapeutic target for heart ...
Thirupura S. Shankar, Dinesh K. A. Ramadurai, Kira Steinhorst, Salah Sommakia, Rachit Badolia, Aspasia Thodou Krokidi, Dallen Calder, Sutip Navankasattusas, Paulina Sander, Oh Sung Kwon, Aishwarya Aravamudhan, Jing Ling, Andreas Dendorfer, Changmin Xie, Ohyun Kwon, Emily H. Y. Cheng, Kevin J. Whitehead, Thomas Gudermann, Russel S. Richardson, Frank B. Sachse, Johann Schredelseker, Kenneth W. Spitzer, Dipayan Chaudhuri, Stavros G. Drakos   +23 more
doaj   +2 more sources

Voltage-Dependent Anion Channel 1(VDAC1) Participates the Apoptosis of the Mitochondrial Dysfunction in Desminopathy. [PDF]

PLoS ONE, 2016
Desminopathies caused by the mutation in the gene coding for desmin are genetically protein aggregation myopathies. Mitochondrial dysfunction is one of pathological changes in the desminopathies at the earliest stage.
Huanyin Li, Lan Zheng, Yanqing Mo, Qi Gong, Aihua Jiang, Jing Zhao   +5 more
doaj   +2 more sources

A 3D model of the voltage‐dependent anion channel (VDAC) [PDF]

FEBS Letters, 2002
Eukaryotic porins are a group of membrane proteins whose best known role is to form an aqueous pore channel in the mitochondrial outer membrane. As opposed to the bacterial porins (a large family of protein whose 3D structure has been determined by X‐ray diffraction), the structure of eukaryotic porins (also termed VDACs, voltage‐dependent anion ...
Casadio, Rita, Jacoboni, Irene, Messina, Angela, De Pinto, Vito   +3 more
openaire   +4 more sources

Is the Voltage-Dependent Anion Channel a Major Player in Neurodegenerative Diseases? [PDF]

Int J Mol Sci
The family of voltage-dependent anion channels (VDAC) comprises three isoforms (VDAC-1, VDAC-2, VDAC-3). VDAC has been extensively described as localized in the outer mitochondrial membrane where it is involved in the exchange of ions, metabolites and ATP/ADP between mitochondria and cytosol.
Neumann S, Heumann R.
europepmc   +3 more sources

Conductance hysteresis in the voltage-dependent anion channel [PDF]

European Biophysics Journal, 2015
Hysteresis in the conductance of voltage-sensitive ion channels is observed when the transmembrane voltage is periodically varied with time. Although this phenomenon has been used in studies of gating of the voltage-dependent anion channel, VDAC, from the outer mitochondrial membrane for nearly four decades, full hysteresis curves have never been ...
Rappaport, Shay M., Teijido Hermida, Óscar, Hoogerheide, David P., Rostovtseva, Tatiana K., Berezhkovskii, Alexander M., Bezrukov, Sergey M.   +5 more
openaire   +4 more sources

The Potential Role of Voltage-Dependent Anion Channel in the Treatment of Parkinson's Disease. [PDF]

Oxid Med Cell Longev, 2022
Parkinson’s disease (PD) is a neurodegenerative disease second only to Alzheimer’s disease in terms of prevalence. Previous studies have indicated that the occurrence and progression of PD are associated with mitochondrial dysfunction. Mitochondrial dysfunction is one of the most important causes for apoptosis of dopaminergic neurons.
He Y, Wang W, Yang T, Thomas ER, Dai R, Li X.   +5 more
europepmc   +3 more sources

Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels. [PDF]

PLoS ONE, 2008
Type II hexokinase is overexpressed in most neoplastic cells, and it mainly localizes on the outer mitochondrial membrane. Hexokinase II dissociation from mitochondria triggers apoptosis.
Federica Chiara, Diego Castellaro, Oriano Marin, Valeria Petronilli, William S Brusilow, Magdalena Juhaszova, Steven J Sollott, Michael Forte, Paolo Bernardi, Andrea Rasola   +9 more
doaj   +1 more source