Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis [PDF]
Nature Communications, 2021 The authors found that VDAC2 plays a crucial role in influencing mitochondrial calcium dynamics and cellular calcium signalling. A VDAC2 agonist, efsevin, rescued the heart failure phenotype, identifying a new potential therapeutic target for heart ...
Thirupura S. Shankar +23 more
doaj +2 more sources
Mitochondrial Ca2+ uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity [PDF]
eLife, 2015 Tightly regulated Ca2+ homeostasis is a prerequisite for proper cardiac function. To dissect the regulatory network of cardiac Ca2+ handling, we performed a chemical suppressor screen on zebrafish tremblor embryos, which suffer from Ca2+ extrusion ...
Hirohito Shimizu +22 more
doaj +4 more sources
MicroED structure of lipid-embedded mammalian mitochondrial voltage-dependent anion channel. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance Microcrystal electron diffraction (MicroED) is an electron cryo-microscopy (cryoEM) method for determining structures using submicron crystals. Until now, determining structures of membrane proteins by MicroED required that the protein crystals be in a solution amenable to standard cryoEM blotting and vitrification ...
Martynowycz MW +4 more
europepmc +7 more sources
Voltage‐dependent anion‐selective channel (VDAC) in the plasma membrane
FEBS Letters, 2010 Voltage‐dependent anion channels (VDACs) have originally been characterized as mitochondrial porins. Starting in the late 1980s, however, evidence began to accumulate that VDACs can also be expressed in plasma membranes. In this review, we briefly revisit the historical milestones in the discovery of plasma membrane‐bound VDAC, and we critically ...
Vito De Pinto +2 more
exaly +3 more sources
Identification and validation of voltage‐dependent anion channel 1‐related genes and immune cell infiltration in diabetic nephropathy [PDF]
Journal of Diabetes InvestigationAims/Introduction This study investigated the roles of voltage‐dependent anion channel 1‐related differentially expressed genes (VRDEGs) in diabetic nephropathy (DN).
Jiaqun Lin +6 more
doaj +2 more sources
Biochimie Open, 2017 Voltage-Dependent Anion Channel (VDAC) phosphorylated by c-Jun N-terminal Kinase-3 (JNK3) was incorporated into the bilayer lipid membrane. Single-channel electrophysiological properties of the native and the phosphorylated VDAC were compared. The open probability versus voltage curve of the native VDAC displayed symmetry around the voltage axis ...
Subhendu Ghosh
exaly +3 more sources
Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels. [PDF]
PLoS ONE, 2008 Type II hexokinase is overexpressed in most neoplastic cells, and it mainly localizes on the outer mitochondrial membrane. Hexokinase II dissociation from mitochondria triggers apoptosis.
Federica Chiara +9 more
doaj +1 more source
VDAC1 (voltage-dependent anion channel 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on VDAC1 (voltage-dependent anion channel 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Shoshan-Barmatz, V, Mizrachi, D
openaire +2 more sources
Conductance hysteresis in the voltage-dependent anion channel [PDF]
European Biophysics Journal, 2015 Hysteresis in the conductance of voltage-sensitive ion channels is observed when the transmembrane voltage is periodically varied with time. Although this phenomenon has been used in studies of gating of the voltage-dependent anion channel, VDAC, from the outer mitochondrial membrane for nearly four decades, full hysteresis curves have never been ...
Rappaport, Shay M. +5 more
openaire +3 more sources
Voltage-dependent anion channels mediated apoptosis in refractory epilepsy [PDF]
Open Medicine, 2020 Abstract The purpose of this study was to investigate the role of voltage-dependent anion channel (VDAC) in mitochondria-mediated apoptosis of neurons in refractory epilepsy. Western blot analyses were carried out to detect the changes in cytochrome C, caspase 9, Bax, and Bcl-2.
Zhao Yan +4 more
openaire +3 more sources