Results 21 to 30 of about 33,802 (280)
The Potential Role of Voltage-Dependent Anion Channel in the Treatment of Parkinson's Disease. [PDF]
Oxid Med Cell Longev, 2022 Parkinson’s disease (PD) is a neurodegenerative disease second only to Alzheimer’s disease in terms of prevalence. Previous studies have indicated that the occurrence and progression of PD are associated with mitochondrial dysfunction. Mitochondrial dysfunction is one of the most important causes for apoptosis of dopaminergic neurons.
He Y +5 more
europepmc +3 more sources
Is the Voltage-Dependent Anion Channel a Major Player in Neurodegenerative Diseases? [PDF]
Int J Mol SciThe family of voltage-dependent anion channels (VDAC) comprises three isoforms (VDAC-1, VDAC-2, VDAC-3). VDAC has been extensively described as localized in the outer mitochondrial membrane where it is involved in the exchange of ions, metabolites and ATP/ADP between mitochondria and cytosol.
Neumann S, Heumann R.
europepmc +3 more sources
A 3D model of the voltage‐dependent anion channel (VDAC) [PDF]
FEBS Letters, 2002 Eukaryotic porins are a group of membrane proteins whose best known role is to form an aqueous pore channel in the mitochondrial outer membrane. As opposed to the bacterial porins (a large family of protein whose 3D structure has been determined by X‐ray diffraction), the structure of eukaryotic porins (also termed VDACs, voltage‐dependent anion ...
Casadio, Rita +3 more
openaire +4 more sources
Conductance hysteresis in the voltage-dependent anion channel [PDF]
European Biophysics Journal, 2015 Hysteresis in the conductance of voltage-sensitive ion channels is observed when the transmembrane voltage is periodically varied with time. Although this phenomenon has been used in studies of gating of the voltage-dependent anion channel, VDAC, from the outer mitochondrial membrane for nearly four decades, full hysteresis curves have never been ...
Rappaport, Shay M. +5 more
openaire +4 more sources
Voltage-Dependent Anion Selective Channel Isoforms in Yeast: Expression, Structure, and Functions
Frontiers in Physiology, 2021 Mitochondrial porins, also known as voltage-dependent anion selective channels (VDACs), are pore-forming molecules of the outer mitochondrial membranes, involved in the regulation of metabolic flux between cytosol and mitochondria.
Maria Carmela Di Rosa +7 more
doaj +1 more source
Nucleotide Interactions of the Human Voltage-dependent Anion Channel [PDF]
Journal of Biological Chemistry, 2014 The voltage-dependent anion channel (VDAC) mediates and gates the flux of metabolites and ions across the outer mitochondrial membrane and is a key player in cellular metabolism and apoptosis. Here we characterized the binding of nucleotides to human VDAC1 (hVDAC1) on a single-residue level using NMR spectroscopy and site-directed mutagenesis.
Saskia Villinger +6 more
openaire +5 more sources
Deficiency of the Voltage-Dependent Anion Channel: A Novel Cause of Mitochondriopathy [PDF]
Pediatric Research, 1996 A patient with a deficient voltage-dependent anion channel (VDAC) is reported, presenting clinically with psychomotor retardation and minor dysmorphic features. Biochemical studies on muscle mitochondria showed impaired rates of pyruvate oxidation and ATP production; however, no specific deficient activity of one of the mitochondrial enzymes was ...
Huizing M +8 more
openaire +4 more sources
High conductance anion channel in Schwann cell vesicles from rat spinal roots [PDF]
, 1992 Potassium uptake, possibly together with chloride, is one of the presumed functions of Schwann cells in the peripheral nervous system. However, the presence of chloride channels has not been demonstrated in adult Schwann cells.
Quasthoff, Stefan +5 more
core +1 more source
A Lipid Bilayer Formed on a Hydrogel Bead for Single Ion Channel Recordings
Micromachines, 2020 Ion channel proteins play important roles in various cell functions, making them attractive drug targets. Artificial lipid bilayer recording is a technique used to measure the ion transport activities of channel proteins with high sensitivity and ...
Minako Hirano +6 more
doaj +1 more source
Voltage-Dependent Anion Channel-1, a Possible Ligand of Plasminogen Kringle 5. [PDF]
PLoS ONE, 2016 Kringle 5, the fifth fragment of plasminogen, is known to be important for inhibiting the proliferation and migration of vascular endothelial cell (VEC), while not having any effects on normal endothelial cells.
Yin-Ku Liang, Liu-Jiao Bian
doaj +1 more source