Results 81 to 90 of about 71,736 (190)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 Background The cardiac microvascular system ischemia/reperfusion injury following percutaneous coronary intervention is a clinical thorny problem. This study explores the mechanisms by which ischemia/reperfusion injury induces cardiac microcirculation ...
Hao Zhou +8 more
doaj +1 more source
Cell Reports, 2013 Protein modification by O-linked β-N-acetylglucosamine (O-GlcNAc) is a critical cell signaling modality, but identifying signal-specific O-GlcNAcylation events remains a significant experimental challenge.
Krishnan K. Palaniappan +7 more
doaj +1 more source
LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion
Nature Communications, 2018 Insulin secretion by β-cells is stimulated by glucose and is dependent on the induction of β-cell membrane depolarization, mainly driven by the closure of KATP channels, which in turn promotes voltage-gated Ca2+ channel opening.
Till Stuhlmann +2 more
doaj +1 more source
Theory of STM junctions for \pi-conjugated molecules on thin insulating films [PDF]
, 2012 A microscopic theory of the transport in a scanning tunnelling microscope (STM) set-up is introduced for \pi-conjugated molecules on insulating films, based on the density matrix formalism.
Andrea Donarini +6 more
core +2 more sources
Structure of the CLC-1 chloride channel from Homo sapiens. [PDF]
, 2018 CLC channels mediate passive Cl- conduction, while CLC transporters mediate active Cl- transport coupled to H+ transport in the opposite direction. The distinction between CLC-0/1/2 channels and CLC transporters seems undetectable by amino acid sequence.
MacKinnon, Roderick, Park, Eunyong
core +2 more sources
Novel hybrid action of GABA mediates inhibitory feedback in the mammalian retina.
PLoS Biology, 2019 The stream of visual information sent from photoreceptors to second-order bipolar cells is intercepted by laterally interacting horizontal cells that generate feedback to optimize and improve the efficiency of signal transmission.
James C R Grove +7 more
doaj +1 more source
Silencing VDAC1 Expression by siRNA Inhibits Cancer Cell Proliferation and Tumor Growth In Vivo
Molecular Therapy: Nucleic Acids, 2014 Alterations in cellular metabolism and bioenergetics are vital for cancer cell growth and motility. Here, the role of the mitochondrial protein voltage-dependent anion channel (VDAC1), a master gatekeeper regulating the flux of metabolites and ions ...
Tasleem Arif +4 more
doaj +1 more source
Evolutionary Covariant Positions within Calmodulin EF-hand Sequences Promote Ligand Binding [PDF]
, 2018 Intracellular calcium signaling is an essential regulatory mechanism through calcium-mediated signal transduction pathways involved in many cell processes, such as exocytosis, motility, apoptosis, excitability, transcription, and muscle contraction.
Vaidyanathan, Uma
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A chloride channel in rat and human axons [PDF]
, 1991 Current recordings from single chloride channels were obtained from excised and cell-attached patches of rat and human axons. In rat axons the channels showed an outwardly rectifying current-voltage relationship with a slope conductance of 33 pS at ...
Baker +19 more
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Cellular Physiology and Biochemistry, 2014 Background/Aims: Voltage-dependent anion channels (VDAC), also known as eukaryotic porins, are located in the outer mitochondrial membrane and allow the flux of ions and small metabolites. While the pore-forming ability of recombinant VDAC1 and VDAC2 has
Vanessa Checchetto +4 more
doaj +1 more source