Mitochondria-Associated Endoplasmic Reticulum Membranes as Potential Therapeutic Targets in Epilepsy. [PDF]
CNS Neurosci TherSun H, Li X, Zhao W, Zhang W, Meng H.
europepmc +1 more source
Developing a Novel and Optimized Yeast Model for Human VDAC Research. [PDF]
Int J Mol SciBaranek-Grabińska M +4 more
europepmc +1 more source
Progress in the study of ion channel function, mechanisms, and mathematical modeling in Parkinson's disease. [PDF]
iScienceWang R, Zeng X, Zhang Z, Ma D.
europepmc +1 more source
Voltage‐dependent anion‐selective channel (VDAC) in the plasma membrane
FEBS Letters, 2010 Voltage‐dependent anion channels (VDACs) have originally been characterized as mitochondrial porins. Starting in the late 1980s, however, evidence began to accumulate that VDACs can also be expressed in plasma membranes. In this review, we briefly revisit the historical milestones in the discovery of plasma membrane‐bound VDAC, and we critically ...
Vito De Pinto +2 more
exaly +4 more sources
Modulation of the mitochondrial voltage dependent anion channel (VDAC) by curcumin
Biochimica Et Biophysica Acta - Biomembranes, 2015 Voltage dependent anion channel (VDAC) of mitochondria plays a crucial role in apoptosis. Human VDAC-1, reconstituted in planar lipid bilayer showed reduced conductance when treated with curcumin. Curcumin interacts with residues in the α helical N-terminus of VDAC and in the channel wall, as revealed by molecular docking, followed by mutational ...
Debanjan Tewari +2 more
exaly +4 more sources
A 3D model of the voltage-dependent anion channel (VDAC) [PDF]
FEBS Letters, 2002 Eukaryotic porins are a group of membrane proteins whose best known role is to form an aqueous pore channel in the mitochondrial outer membrane. As opposed to the bacterial porins (a large family of protein whose 3D structure has been determined by X‐ray diffraction), the structure of eukaryotic porins (also termed VDACs, voltage‐dependent anion ...
Rita Casadio +2 more
exaly +4 more sources
Related searches:
Quinidine partially blocks mitochondrial voltage-dependent anion channel (VDAC)
European Biophysics Journal, 2020Quinidine is an antiarrhythmic drug commonly used for the treatment of cardiac ailments. It affects oxidative phosphorylation, calcium uptake, and ion channels of mitochondria. We have investigated the interaction of Quinidine and mitochondrial voltage-dependent anion channel (VDAC).
Chetan Malik, Subhendu Ghosh
exaly +3 more sources
Transmembrane arrangement of mitochondrial porin or voltage-dependent anion channel (VDAC)
Journal of Bioenergetics and Biomembranes, 1992Porin or voltage-dependent anion-selective channel (VDAC) is the main protein responsible for the high permeability of the outer mitochondrial membrane. The mitochondrial porin is mainly composed of sided beta-strands, in analogy with bacterial porin, whose structure has been resolved at 1.8 A resolution.
Vito De Pinto, Ferdinando Palmieri
exaly +4 more sources
Modulation of the voltage-dependent anion channel (VDAC) by glutamate.
Journal of bioenergetics and biomembranes, 2009The voltage-dependent anion channel (VDAC), also known as mitochondrial porin, is a large channel permeable to anions, cations, ATP, and other metabolites. VDAC was purified from sheep brain synaptosomes or rat liver mitochondria using a reactive red-agarose column, in addition to the hydroxyapatitate column.
D, Gincel +2 more
openaire +2 more sources
Voltage-Dependent Anion Channel (VDAC) in Health and Disease
2023Abstract The voltage-dependent anion channel (VDAC) is recognized as the key metabolite pathway of water-soluble metabolites, small ions, and polypeptides across the outer mitochondrial membrane. The significance of this relatively simple β-barrel channel arises from its crucial position at the interface between the mitochondria and ...
Megha Rajendran +2 more
openaire +1 more source