Results 171 to 180 of about 9,496 (202)
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Purification of VDAC (Voltage-dependent anion-selective channel) from rat liver mitochondria
Journal of Membrane Biology, 1983The outer membrane of rat liver mitochondria contains a channel-forming protein known as VDAC (voltage-dependent anion-selective channel). This protein has been functionally purified by a combination of ion exchange chromatography, gel filtration and affinity chromatography on a Concanavalin A-containing column.
Marco Colombini, Colombini Marco
exaly +3 more sources
Expression and localization of voltage-dependent anion channels (VDAC) in human spermatozoa
Biochemical and Biophysical Research Communications, 2009Voltage-dependent anion channels (VDAC), also known as mitochondrial porins, are a group of proteins first identified in the mitochondrial outer membrane that are able to form hydrophilic pore structures. VDAC allow the passage of the metabolites across the mitochondrial outer membrane, and are involved in metabolite transport and signal transduction ...
Bianjiang, Liu +3 more
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Journal of Bioenergetics and Biomembranes, 2008
Normal cells of aerobic organisms synthesize the energy they require in the form of ATP via the process of oxidative phosphorylation. This complex system resides in the mitochondria of cells and utilizes oxygen to produce a majority of cellular ATP.
Andrew M, Campbell, Samuel H P, Chan
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Normal cells of aerobic organisms synthesize the energy they require in the form of ATP via the process of oxidative phosphorylation. This complex system resides in the mitochondria of cells and utilizes oxygen to produce a majority of cellular ATP.
Andrew M, Campbell, Samuel H P, Chan
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Annals of the New York Academy of Sciences, 1980
VDAC is a channel-forming protein, located in the outer mitochondrial membrane, whose properties are consistent with the known permeability behavior of that membrane. When extracted with Triton X-100, VDAC exists as a 110,000 molecular weight glycoprotein complex which is a prepackaged channel. When inserted into liposomes, the permeability increase to
Marco Colombini
exaly +2 more sources
VDAC is a channel-forming protein, located in the outer mitochondrial membrane, whose properties are consistent with the known permeability behavior of that membrane. When extracted with Triton X-100, VDAC exists as a 110,000 molecular weight glycoprotein complex which is a prepackaged channel. When inserted into liposomes, the permeability increase to
Marco Colombini
exaly +2 more sources
Structural Analysis of Murine Voltage Dependent Anion Channel (VDAC) 1
The FASEB Journal, 2006VDAC is a mammalian integral protein expressed in the outer mitochondrial membrane. It has a bi‐functional role in mitochondrial biology: under physiological conditions, it transports nucleotides and small molecules across the outer membrane and
Rachna Ujwal +6 more
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Current Medicinal Chemistry, 2003
Voltage-dependent anion channels (VDAC) are major constituents of the outer mitochondrial membrane. Over the past few years, several hypotheses and mechanisms have been forwarded for and against a role for VDAC in outer mitochondrial membrane permeability and the subsequent release of apoptosis promoting factors.
David J, Granville, Roberta A, Gottlieb
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Voltage-dependent anion channels (VDAC) are major constituents of the outer mitochondrial membrane. Over the past few years, several hypotheses and mechanisms have been forwarded for and against a role for VDAC in outer mitochondrial membrane permeability and the subsequent release of apoptosis promoting factors.
David J, Granville, Roberta A, Gottlieb
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European Biophysics Journal, 2020
The Voltage-Dependent Anion Channel (VDAC) plays a vital role in mitochondria-mediated transport of ions and metabolites. It is well established that mitochondria are a site for production of hydrogen peroxide (H2O2). Excess production of H2O2 is toxic to the cell and causes oxidative stress.
Chetan Malik, Subhendu Ghosh
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The Voltage-Dependent Anion Channel (VDAC) plays a vital role in mitochondria-mediated transport of ions and metabolites. It is well established that mitochondria are a site for production of hydrogen peroxide (H2O2). Excess production of H2O2 is toxic to the cell and causes oxidative stress.
Chetan Malik, Subhendu Ghosh
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Journal of Bioenergetics and Biomembranes, 2008
Recently, it was demonstrated that some anti-cancer agents used mitochondrial voltage-dependent anion channels (VDAC1-3 isoforms) as their pharmacological target. VDACs are expressed more highly in cancer cells than normal cells; thus the VDAC-dependent cytotoxic agents can have cancer-selectivity. Furanonaphthoquinones (FNQs) induced caspase-dependent
Eriko, Simamura +3 more
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Recently, it was demonstrated that some anti-cancer agents used mitochondrial voltage-dependent anion channels (VDAC1-3 isoforms) as their pharmacological target. VDACs are expressed more highly in cancer cells than normal cells; thus the VDAC-dependent cytotoxic agents can have cancer-selectivity. Furanonaphthoquinones (FNQs) induced caspase-dependent
Eriko, Simamura +3 more
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[Voltage-dependent anion channels (VDAC) on human sperm membrane].
Zhonghua nan ke xue = National journal of andrology, 2007To further study gene expression and characterization of voltage-dependent anion channels (VDACs) on human spermatozoa.VDACs were cloned by PCR from the testis cDNA library. Recombinant human sperm VDACs were produced in E. coli system by molecular cloning technology.
Zeng-jun, Wang +3 more
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Current Pharmaceutical Design, 2006
Research over the last decade has extended the prevailing view of mitochondria to include functions well beyond the critical bioenergetics role in supplying ATP. It is now recognized that mitochondria play a crucial role in cell signaling events, inter-organelle communication, aging, many diseases, cell proliferation and cell death.
V, Shoshan-Barmatz +3 more
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Research over the last decade has extended the prevailing view of mitochondria to include functions well beyond the critical bioenergetics role in supplying ATP. It is now recognized that mitochondria play a crucial role in cell signaling events, inter-organelle communication, aging, many diseases, cell proliferation and cell death.
V, Shoshan-Barmatz +3 more
openaire +2 more sources