Results 271 to 280 of about 95,928 (309)

Extracellular Calcium Sensitivity and Voltage-Dependent Calcium Channels in C Cells*

Endocrine Reviews, 1995
An essential function of C cells is to monitor [Ca2+]e and to increase CT secretion in response to small increments in [Ca2+]e. CT, in turn, decreases [Ca2+]e via its effects on bone and kidney. [Ca2+]e-dependent CT secretion is known to be mediated by corresponding changes in [Ca2+]i.
F, Raue, H, Scherübl
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PKCε upregulates voltage‐dependent calcium channels in cultured astrocytes

Glia, 2007
AbstractAstrocytes express voltage‐gated calcium channels (VGCCs) that are upregulated in the context of the reactive astrogliosis occurring in several CNS pathologies. Moreover, the ability of selective calcium channel blockers to inhibit reactive astrogliosis has been revealed in a variety of experimental models. However, the functions and regulation
M, Burgos, M D, Pastor, J C, González, J R, Martinez-Galan, C F, Vaquero, N, Fradejas, A, Benavides, J M, Hernández-Guijo, P, Tranque, S, Calvo   +9 more
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Molecular determinants of voltage-dependent inactivation in calcium channels

Nature, 1994
Voltage-dependent Ca2+ channels respond to membrane depolarization by conformational changes that control channel opening and eventual closing by inactivation. The kinetics of inactivation differ considerably between types of Ca2+ channels and are important in determining the amount of Ca2+ entry during electrical activity and its resulting impact on ...
J F, Zhang, P T, Ellinor, R W, Aldrich, R W, Tsien   +3 more
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Modulation of voltage-dependent calcium channels by G proteins

Current Opinion in Neurobiology, 1998
Voltage-gated calcium channels are found in all excitable cells, in which they regulate many important physiological functions, including excitability, gene transcription, muscle contraction, and neurotransmitter and hormone release. The differential modulation of calcium channels by intracellular second messengers constitutes a key mechanism for ...
G W, Zamponi, T P, Snutch
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Voltage-dependent calcium channels: structures and drug-binding sites

Biochemical Society Transactions, 1992
I47 Tsien’s group classified these channels as ‘N, ‘T, In the 1960s the research groups of Fleckenstein and Godfraind defined ‘calcium antagonists’ as agents which blocked the entry of calcium into cells via voltage-dependent calcium channels. In a literature search we found 74 compounds in various stages of clinical or preclinical development classed ...
M, Spedding, B, Kenny
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Noradrenaline contracts arteries by activating voltage-dependent calcium channels

Nature, 1988
Noradrenaline (NA) regulates arterial smooth muscle tone and hence blood vessel diameter and blood flow. NA apparently increases tone by causing a calcium influx through the cell membrane. Two calcium influx pathways have been proposed: voltage-activated calcium channels and NA-activated calcium-permeable channels that are voltage-insensitive. Although
Nelson, M. T., Standen, N. B., Brayden, J. E., Worley, J. F.   +3 more
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Effect of Aging on Brain Voltage-Dependent Calcium Channels

1993
Control of interneuronal communication involves a variety of homeostatic mechanisms in which free calcium ions play a fundamental role (1). An altered metabolism of calcium in the brain that occurs with aging has been observed since the beginning of this century (2).
BATTAINI, FIORENZO MARIA, TRABUCCHI, MARCO MARIO, Chikvaidze, V, Govoni, S.   +3 more
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Voltage-Dependent and Receptor-Operated Calcium Channels

1995
Contraction of airways smooth muscle is universally accepted as being the principal component of the acute phase of airflow limitation that characterizes an asthmatic attack. It is also acknowledged that the airway structure of asthmatic subjects is abnormal.
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Structural properties of voltage-dependent calcium channels.

International review of cytology, 1993
Following purification using Ca2+ channel drugs as ligands, the skeletal muscle Ca2+ channel was shown to be a five-subunit structure containing one large (175 kDa) protein that is the pore and four auxiliary subunits. Each subunit has been cloned and expression studies are proceeding rapidly.
E W, McCleskey, M D, Womack, L A, Fieber
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Molecular Diversity of Voltage‐Dependent Calcium Channel

Annals of the New York Academy of Sciences, 1993
YASUO MORI, TETSUHIRO NIIDOME, YOSHIHIKO FUJITA, MICHELLE MYNLIEFF, ROBERT T. DIRKSEN, KURT G. BEAM, NAOYUKI IWABE, TAKASHI MIYATA, DAISUKE FURUTAMA, TEIICHI FURUICHI, KATSUHIKO MIKOSHIBA   +10 more
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