Results 191 to 200 of about 116,855 (342)

Sex-specific modulation of T-type voltage-gated calcium channels in the renal artery of hypertensive rats. [PDF]

Front Physiol
Suarez A, Guerra-Ojeda S, Valls A, Verdú D, Serna-García M, Herrera G, Serna E, Mauricio MD.   +7 more
europepmc   +1 more source

Development of next-generation voltage-gated calcium channel inhibitors using engineered nanobodies

, 2021
Travis J. Morgenstern
openalex   +1 more source

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

Phylogenetic Analysis of the in vitro Protein-Protein interactions between the PDZ domain of Rab3-interacting molecule (RIM), and the extreme C-terminus (CT) of Voltage-gated Calcium (CaV2) Channels

, 2023
Brian Bejoy
openalex   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

Differential contribution of α2δ auxiliary subunits of voltage-gated calcium channels in mouse models of pain and itch. [PDF]

PLoS One
Braz JM, Jewell M, Bhardwaj K, Rodriguez-Rosado S, Craik V, Basbaum AI.   +5 more
europepmc   +1 more source

Small Molecules as Modulators of Voltage-Gated Calcium Channels in Neurological Disorders: State of the Art and Perspectives. [PDF]

Molecules, 2022
Lanzetti S, Di Biase V.
europepmc   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Differential contribution of T-type voltage-gated calcium channels to vascular reactivity in the aorta and renal artery of healthy rabbits. [PDF]

Exp Physiol
Suarez A, Guerra-Ojeda S, Zarzoso M, Serna-García M, Vila JM, Serna E, Mauricio MD.   +6 more
europepmc   +1 more source

Betulinic acid analogs inhibit N- and T-type voltage-gated calcium channels to attenuate nerve-injury associated neuropathic and formalin models of pain. [PDF]

Neurobiol Pain, 2023
Calderon-Rivera A, Gomez K, Loya-López S, Wijeratne EMK, Stratton H, Tang C, Duran P, Masterson K, Alsbiei O, Gunatilaka AAL, Khanna R.   +10 more
europepmc   +1 more source