Results 201 to 210 of about 116,855 (342)

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Degradation of voltage-gated calcium channels: mechanisms and applications in neurological and cardiovascular diseases. [PDF]

Cell Commun Signal
Liu L, Zhou Y, Liao P, Soong TW, Hu Z.
europepmc   +1 more source

Role of L-Type Voltage-Gated Calcium Channels in Epileptiform Activity of Neurons. [PDF]

Int J Mol Sci, 2021
Laryushkin DP, Maiorov SA, Zinchenko VP, Gaidin SG, Kosenkov AM.   +4 more
europepmc   +1 more source

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

Crotoxin B from the South American Rattlesnake Crotalus vegrandis Blocks Voltage-Gated Calcium Channels Independent of Its Intrinsic Catalytic Activity. [PDF]

Toxins (Basel)
Eicheldinger M, Miranda-Laferte E, Castilla F, Jordan N, Santiago-Schübel B, Hidalgo P.   +5 more
europepmc   +1 more source

The β₂-Subunit of Voltage-Gated Calcium Channels Regulates Cardiomyocyte Hypertrophy. [PDF]

Front Cardiovasc Med, 2021
Pickel S, Cruz-Garcia Y, Bandleon S, Barkovits K, Heindl C, Völker K, Abeßer M, Pfeiffer K, Schaaf A, Marcus K, Eder-Negrin P, Kuhn M, Miranda-Laferte E.   +12 more
europepmc   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

TNF-α exacerbates calcium influx via voltage-gated calcium channels in breast cancer cells: a nanoscale multimodal AFM study. [PDF]

Front Cell Dev Biol
Wang Z, Xu Q, Zhang H, Feng R, Chen J, Wei J, Zhong H, Zhao W.   +7 more
europepmc   +1 more source

Animal Venom Peptides Cause Antinociceptive Effects by Voltage-gated Calcium Channels Activity Blockage. [PDF]

Curr Neuropharmacol, 2022
Trevisan G, Oliveira SM.
europepmc   +1 more source

Modulation of TMEM16A channel activity by the von Willebrand factor type A (VWA) domain of the calcium-activated chloride channel regulator 1 (CLCA1) [PDF]

, 2017
Berry, Kayla N, Brett, Tom J, Nichols, Colin G, Sala-Rabanal, Monica, Yurtsever, Zeynep   +4 more
core   +2 more sources