Results 211 to 220 of about 63,537 (256)
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Calcium Channelopathies: Voltage-Gated Calcium Channels
2007Since the initial identification of native calcium currents, significant progress has been made towards our understanding of the molecular and cellular contributions of voltage-gated calcium channels in multiple physiological processes. Moreover, we are beginning to comprehend their pathophysiological roles through both naturally occurring ...
P J, Adams, T P, Snutch
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Voltage-Gated Calcium Channels in Nociception
2008Voltage-gated calcium channels (VGCCs) are a large and functionally diverse group of membrane ion channels ubiquitously expressed throughout the central and peripheral nervous systems. VGCCs contribute to various physiological processes and transduce electrical activity into other cellular functions.
Yasuda, T., Adams, D. J.
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Voltage-Gated Calcium Channels
2019Abstract Voltage-gated calcium channels are important contributors to the transmission and processing of nociceptive information in the primary afferent pain pathway. Several types of calcium channels and their ancillary subunits are dysregulated in response to nerve injury or inflammation.
Gerald W. Zamponi +2 more
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Therapeutic Potential of Voltage Gated Calcium Channels
Mini-Reviews in Medicinal Chemistry, 2008Voltage-gated Calcium channels (VGCCs) play important roles in neurotransmitter release, excitation-contraction coupling, hormone secretion, and a variety of other physiological processes. Currently, there exist ion channel therapeutics for anxiety, epilepsy, hypertension, insomnia and pain.
C Gopi, Mohan, Tamanna, Gandhi
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Peptides Targeting Voltage-Gated Calcium Channels
Current Pharmaceutical Design, 2008Many peptides are potent and highly selective blockers or modulators of calcium channel function, and as such are valuable pharmacological tools and potentially valuable leads for the development of human therapeutics. Cone shells and spiders are rich sources of such peptides, although they are also found in scorpions and insects.
Raymond S, Norton, Stefan I, McDonough
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Voltage-gated calcium channels and Parkinson's disease
Pharmacology & Therapeutics, 2012A complex interaction of environmental, genetic and epigenetic factors combine with ageing to cause the most prevalent of movement disorders Parkinson's disease. Current pharmacological treatments only tackle the symptoms and do not stop progression of the disease or reverse the neurodegenerative process.
Hurley, Michael J., Dexter, David T.
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[Voltage-gated calcium channels].
Uspekhi fiziologicheskikh nauk, 2006The article concentrates on representatives of voltage-gated calcium ion-channels that are present in practically all cells. Considered are the activation and inactivation processes of calcium channels and their molecular mechanisms. The review represents modem classification of voltage-gated calcium channels, draws parallels with the earlier ...
A G, Kamkin +3 more
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Voltage-Gated Calcium Channels in Epilepsy
2012Abstract Voltage-gated calcium channels are integral membrane proteins that form calcium-selective pores in the plasma membrane (Fig. 6–1). Calcium ions flowing into the cell are driven by an electrochemical gradient generated by a high concentration of calcium outside the cell to a low calcium concentration inside.
Stuart M. Cain, Terrance P. Snutch
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The naming of voltage-gated calcium channels
Neuron, 1994Lutz Birnbaumer +10 more
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