Results 71 to 80 of about 157,979 (315)

An Experimental High‐Throughput Approach for the Screening of Hard Magnet Materials

Advanced Engineering Materials, EarlyView.
An entire workflow for the high‐throughput characterization and analysis of compositionally graded magnetic films is presented. Characterization protocols, data management tools and data analysis approaches are illustrated with test case Sm(Fe, V)12 based films.
William Rigaut, Pierre Le Berre, Hamdi Jaballah, Lukas Fink, Victor Poline, Richard Haettel, Stéphane Grenier, Gilbert Chahine, Ewen Bellec, Guillaume Buatier, Wilfried Hortschitz, Santa Pile, Thomas Schrefl, Nils Blanc, Yuan Hong, Thibaut Devillers, Nora M. Dempsey   +16 more
wiley   +1 more source

Altered expression of the voltage-gated calcium channel subunit α2δ-1: a comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain.

, 2014
The auxiliary α2δ-1 subunit of voltage-gated calcium channels is up-regulated in dorsal root ganglion neurons following peripheral somatosensory nerve damage, in several animal models of neuropathic pain.
Sandhu, G, Bauer, CS, Dolphin, AC, Jiruska, P., Jefferys, J.G.R., Nieto-Rostro, M., Sandhu, G., Dolphin, A.C., Bauer, C.S., Jiruska, P, Nieto-Rostro, M, Jefferys, JG   +11 more
core   +1 more source

An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids [PDF]

, 2015
We describe the identification in aphids of a unique heterodimeric voltage-gated sodium channel which has an atypical ion selectivity filter and, unusually for insect channels, is highly insensitive to tetrodotoxin.
T. G. E. Davies (7694750), Joanna S. Amey, O'Reilly, Andrias O., Mellor, I. R., Burton, Mark J., M. S. Williamson (7694747), Martin S. Williamson, Duce, I. R., Mellor, I.R., B.A. Wallace, Andrias O. O'Reilly, O'Reilly, A. O., Mark J. Burton, Burton, M. J., Field, L.M., A. O. O'Reilly (7694732), Amey, Joanna S., Puinean, A. M., Davies, T.G. Emyr, T.G. Emyr Davies, A. M. Puinean (7694735), O’Reilly, Andrias O., Williamson, Martin S., Amey, J.S., Duce, Ian R., Williamson, M.S., I. R. Mellor (7694738), Duce, I.R., Field, Linda M., Linda M. Field, Mark J. Burton (7691339), Field, L. M., Alin M. Puinean, Ian R. Duce, Amey, J. S., Wallace, B.A., Ian R. Mellor, J. S. Amey (7694729), Davies, T. G. E., Williamson, M. S., B. A. Wallace (148558), I. R. Duce (7694741), Wallace, Bonnie A., Puinean, Alin M., Mellor, Ian R., L. M. Field (7694744), Wallace, B. A., Davies, T.G.E., Burton, M.J., Puinean, A.M.   +49 more
core   +1 more source

Reconfigurable Logic‐in‐Memory Operations Enabled by Triple‐Gated Feedback Field‐Effect Transistors for Area‐Efficient Computing

Advanced Engineering Materials, EarlyView.
A reconfigurable logic‐in‐memory cell composed of triple‐gated feedback field‐effect transistors implements multiple combinational logic functions within a single configuration. By utilizing program gates as dynamic input terminals, the proposed cell performs full adder, full subtractor, 2‐to‐1 multiplexer, and 4‐to‐2 encoder operations without ...
Minhyeok Seol, Yunwoo Shin, Donghyung Lee, Dongki Kim, Kyoungah Cho, Sangsig Kim   +5 more
wiley   +1 more source

Thermodynamics of voltage-gated ion channels [PDF]

Biophysics Reports, 2018
Ion channels are essential for cellular signaling. Voltage-gated ion channels (VGICs) are the largest and most extensively studied superfamily of ion channels. They possess modular structural features such as voltage-sensing domains that encircle and form mechanical connections with the pore-forming domains.
Zhang, Xuejun C., Yang, Hanting, Liu, Zhenfeng, Sun, Fei   +3 more
openaire   +2 more sources

Microglial K(+) channel expression in young adult and aged mice.

, 2015
The K(+) channel expression pattern of microglia strongly depends on the cells' microenvironment and has been recognized as a sensitive marker of the cells' functional state. While numerous studies have been performed on microglia in vitro, our knowledge
Tom Schilling, Schilling, T, Eder, C, Claudia Eder   +3 more
core   +1 more source

All‐in‐One Analog AI Hardware: On‐Chip Training and Inference with Conductive‐Metal‐Oxide/HfOx ReRAM Devices

Advanced Functional Materials, EarlyView.
An all‐in‐one analog AI accelerator is presented, enabling on‐chip training, weight retention, and long‐term inference acceleration. It leverages a BEOL‐integrated CMO/HfOx ReRAM array with low‐voltage operation (<1.5 V), multi‐bit capability over 32 states, low programming noise (10 nS), and near‐ideal weight transfer.
Donato Francesco Falcone, Victoria Clerico, Wooseok Choi, Tommaso Stecconi, Folkert Horst, Laura Bégon‐Lours, Matteo Galetta, Antonio La Porta, Nikhil Garg, Fabien Alibart, Bert Jan Offrein, Valeria Bragaglia   +11 more
wiley   +1 more source

Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors

JCI Insight, 2021
SCN2A, encoding the neuronal voltage-gated Na+ channel NaV1.2, is one of the most commonly affected loci linked to autism spectrum disorders (ASDs). Most ASD-associated mutations in SCN2A are loss-of-function mutations, but studies examining how such ...
Hong-Gang Wang, Charlotte C. Bavley, Anfei Li, Rebecca M. Jones, Jonathan Hackett, Yared Bayleyen, Francis S. Lee, Anjali M. Rajadhyaksha, Geoffrey S. Pitt   +8 more
doaj   +1 more source

Drug binding sites on Nat1.8 sodium channels [PDF]

, 2008
The voltage-gated sodium channel, Nav 1.8, is known to play an important role in pain signalling. In this thesis, the functional properties and drug binding sites of wild type and mutant Nav 1.8 sodium channel currents were studied in mammalian sensory ...
Browne, Liam Edward
core  

Electrophysiological characterization of activation state-dependent Cav2 channel antagonist TROX-1 in spinal nerve injured rats.

, 2015
Prialt, a synthetic version of Cav2.2 antagonist ω-conotoxin MVIIA derived from Conus magus, is the first clinically approved voltage-gated calcium channel blocker for refractory chronic pain.
Schiene, K., Damann, N., Damann, N, Rutten, K., Wigge, S., Schiene, K, Christoph, T., Schunk, S., Valdor, M, Valdor, M., Rutten, K, Schunk, S, Patel, R, Dickenson, A.H., Christoph, T, Wigge, S, Patel, R., Dickenson, AH   +17 more
core   +1 more source