Results 51 to 60 of about 157,979 (315)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Effects of Voltage-Gated K+ Channel on Cell Proliferation in Multiple Myeloma

The Scientific World Journal, 2014
Objective. To study the effects and underlying mechanisms of voltage-gated K+ channels on the proliferation of multiple myeloma cells. Methods. RPMI-8226 MM cell line was used for the experiments.
Wei Wang, Yuying Fan, Shuye Wang, Lianjie Wang, Wanting He, Qiu Zhang, Xiaoxia Li   +6 more
doaj   +1 more source

Artificial modulation of the gating behavior of a K+ channel in a KvAP-DNA chimera. [PDF]

PLoS ONE, 2011
We present experiments where the gating behavior of a voltage-gated ion channel is modulated by artificial ligand binding. We construct a channel-DNA chimera with the KvAP potassium channel reconstituted in an artificial membrane.
Andrew Wang, Giovanni Zocchi
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Voltage-Gated Sodium Channels: A Therapeutic Target in Ischemic Heart Disease

Reviews in Cardiovascular Medicine
Myocardial infarction (MI)-related arrhythmias are an essential risk factor in sudden cardiac death. Aberrant cardiac the cardiac voltage-gated sodium channel (Nav1.5) is important in the development of ventricular arrhythmias after an MI.
Xiao-Lu Zhang, Tian-Peng Wei, Fan Yang, Huan-Huan Liu, Ling-Ling Qian, Ru-Xing Wang   +5 more
doaj   +1 more source

Opposite effects of the S4-S5 linker and PIP2 on voltage-gated channel function: KCNQ1/KCNE1 and other channels

Frontiers in Pharmacology, 2012
Voltage-gated potassium (Kv) channels are tetramers, each subunit presenting six transmembrane segments (S1-S6), with each S1-S4 segments forming a voltage-sensing domain (VSD) and the four S5-S6 forming both the conduction pathway and its gate.
Frank S Choveau, Frank S Choveau, Frank S Choveau, Fayal eAbderemane-Ali, Fayal eAbderemane-Ali, Fayal eAbderemane-Ali, Fabien C Coyan, Zeineb eEs-Salah-Lamoureux, Zeineb eEs-Salah-Lamoureux, Fabien C Coyan, Fabien C Coyan, Zeineb eEs-Salah-Lamoureux, Isabelle eBaro, Isabelle eBaro, Isabelle eBaro, Gildas eLoussouarn, Gildas eLoussouarn, Gildas eLoussouarn   +17 more
doaj   +1 more source

Mutations in the voltage-gated sodium channel gene associated with deltamethrin resistance in commercially sourced Phytoseiulus persimilis [PDF]

, 2020
The implementation of Integrated Pest Management (IPM) in current agricultural practice is a convenient and very effective strategy to maintain pest populations under control. The use of Biological Control Agents, like Phytoseiulus persimilis, is key for
M. Alonso, Benavent-Albarracin, L., Urbaneja, A., Catalan, J., J. González‐Cabrera, T. G. E. Davies, Gonzalez-Cabrera, J., M. S. Williamson, J. Catalán, Alonso, M., Davies, T. G. E., A. Urbaneja, Williamson, M. S., L. Benavent‐Albarracín   +13 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

LRRK2 regulates voltage-gated calcium channel function.

Frontiers in Molecular Neuroscience, 2016
Voltage-gated Ca2+ (CaV) channels enable Ca2+ influx in response to membrane depolarization. CaV2.1 channels are localized to the presynaptic membrane of many types of neurons where they are involved in triggering neurotransmitter release.
Cade eBedford, Catherine eSears, Maria ePerez-Carrion, Giovanni ePiccoli, Steven eCondliffe   +4 more
doaj   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source