Results 61 to 70 of about 157,979 (315)
High conductance anion channel in Schwann cell vesicles from rat spinal roots [PDF]
, 1992 Potassium uptake, possibly together with chloride, is one of the presumed functions of Schwann cells in the peripheral nervous system. However, the presence of chloride channels has not been demonstrated in adult Schwann cells.
Quasthoff, Stefan +5 more
core +1 more source
Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source
PLoS Computational Biology, 2007 The activity of trans-membrane proteins such as ion channels is the essence of neuronal transmission. The currently most accurate method for determining ion channel kinetic mechanisms is single-channel recording and analysis.
Meron Gurkiewicz, Alon Korngreen
doaj +1 more source
Outward Rectification of Voltage-Gated K+ Channels Evolved at Least Twice in Life History. [PDF]
PLoS ONE, 2015 Voltage-gated potassium (K+) channels are present in all living systems. Despite high structural similarities in the transmembrane domains (TMD), this K+ channel type segregates into at least two main functional categories-hyperpolarization-activated ...
Janin Riedelsberger +2 more
doaj +1 more source
Structural dynamics determine voltage and pH gating in human voltage-gated proton channel
eLife, 2022 Voltage-gated proton (Hv) channels are standalone voltage sensors without separate ion conductive pores. They are gated by both voltage and transmembrane proton gradient (i.e., ∆pH), serving as acid extruders in most cells.
Shuo Han +7 more
doaj +1 more source
The selectivity, voltage-dependence and acid sensitivity of the tandem pore potassium channel TASK-1 : contributions of the pore domains [PDF]
, 2007 We have investigated the contribution to ionic selectivity of residues in the selectivity filter and pore helices of the P1 and P2 domains in the acid sensitive potassium channel TASK-1.
Sutcliffe, M. J. +14 more
core +1 more source
Arthritis Care &Research, EarlyView.Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo +88 more
wiley +1 more source
Research progress in ion channel mechanism of morphine addiction
Zhongguo linchuang yanjiuMorphine is a classic opioid analgesic drug commonly used to treat chronic pain, cancer pain, neuropathic pain, etc. But repeated use can be addictive, this makes its clinical use severely limited.
CHEN Xia*, WANG Yong, WEI Yiyong
doaj +1 more source
Voltage-gated channel mechanosensitivity: Fact or Friction?
Frontiers in Physiology, 2011 The heart is a continually active pulsatile fluid pump that generates forces by precisely timed and spaced engagement of contractile nano-machinery. This pump largely generates its own control signals, the most crucial of which involve precisely timed ...
Catherine E Morris
doaj +1 more source
Soft Mechanical‐Electrical Logic Using Liquid Metal‐Filled 3D‐Printed Architectures
Advanced Engineering Materials, EarlyView.We present 3D‐printed soft mechanical–electrical logic elements that use liquid metal–filled silicone tubes actuated by thermoplastic polyurethane/polylactic acid (TPU/PLA) architectures to produce Boolean operations. Complementary normally open and normally closed unit cells perform repeatable binary transitions and can be combined into more complex ...
Christoph Lehmann +2 more
wiley +1 more source