Results 41 to 50 of about 157,979 (315)

Historical Perspective of the Characterization of Conotoxins Targeting Voltage-Gated Sodium Channels

Marine Drugs, 2023
Marine toxins have potent actions on diverse sodium ion channels regulated by transmembrane voltage (voltage-gated ion channels) or by neurotransmitters (nicotinic acetylcholine receptor channels).
James R. Groome
doaj   +1 more source

Improved sub-threshold slope in short channel vertical MOSFETs using FILOX oxidation [PDF]

, 2009
This paper investigates the origins of sub-threshold slope degradation in vertical MOSFETs (v-MOSFETs) due to dry etching of the polysilicon surround gate.
Tan, L., Redman-White, W., Ashburn, P, Buiu, O., Hall, S., Hakim, M M A   +5 more
core   +1 more source

Downregulation of L‐Type Voltage‐Gated Ca2+, Voltage‐Gated K+, and Large‐Conductance Ca2+‐Activated K+ Channels in Vascular Myocytes From Salt‐Loading Offspring Rats Exposed to Prenatal Hypoxia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundPrenatal hypoxia is suggested to be associated with increased risks of hypertension in offspring. This study tested whether prenatal hypoxia resulted in salt‐sensitive offspring and its related mechanisms of vascular ion channel remodeling ...
Bailin Liu, Ruixiu Shi, Xiang Li, Yanping Liu, Xueqin Feng, Xueyi Chen, Xiaorong Fan, Yingying Zhang, Wenna Zhang, Jiaqi Tang, Xiuwen Zhou, Na Li, Xiyuan Lu, Zhice Xu   +13 more
doaj   +1 more source

Correction of conductance measurements in non-space-clamped structures: 1. Voltage-gated K+ channels

, 2003
To understand functions of a single neuron, such as propagation and generation of synaptic or action potentials, a detailed description of the kinetics and distribution of the underlying ionic conductances is essential.
Korngreen, A, Helmstaedter, M., Helmstaedter, Moritz, Schaefer, AT, Korngreen, A., Schaefer, A., Sakmann, Bert, Helmstaedter, M, Sakmann, B, Schaefer, Andreas T., Korngreen, Alon, Sakmann, B., Helmstädter, Moritz   +12 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Characterization of voltage-gated Ca(2+) conductances in layer 5 neocortical pyramidal neurons from rats. [PDF]

PLoS ONE, 2009
Neuronal voltage-gated Ca(2+) channels are involved in electrical signalling and in converting these signals into cytoplasmic calcium changes. One important function of voltage-gated Ca(2+) channels is generating regenerative dendritic Ca(2+) spikes ...
Mara Almog, Alon Korngreen
doaj   +1 more source

Philosophy of voltage-gated proton channels [PDF]

Journal of The Royal Society Interface, 2014
In this review, voltage-gated proton channels are considered from a mainly teleological perspective. Why do proton channels exist? What good are they? Why did they go to such lengths to develop several unique hallmark properties such as extreme selectivity andΔpH-dependent gating? Why is their current so minuscule? How do they manage to be so selective?
Thomas E, DeCoursey, Jonathan, Hosler
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Palmitoylation of Voltage-Gated Ion Channels

International Journal of Molecular Sciences, 2022
Protein lipidation is one of the most common forms of posttranslational modification. This alteration couples different lipids, such as fatty acids, phospho- and glycolipids and sterols, to cellular proteins. Lipidation regulates different aspects of the protein’s physiology, including structure, stability and affinity for cellular membranes and ...
Silvia Cassinelli, Carla Viñola-Renart, Anna Benavente-Garcia, María Navarro-Pérez, Jesusa Capera, Antonio Felipe   +5 more
openaire   +2 more sources

Identification of putative potassium channel homologues in pathogenic protozoa [PDF]

, 2012
K(+) channels play a vital homeostatic role in cells and abnormal activity of these channels can dramatically alter cell function and survival, suggesting that they might be attractive drug targets in pathogenic organisms.
Prole, D L, Neil V Marrion, Marrion, NV, David L Prole   +3 more
core   +1 more source